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Determination of pharmaceuticals in wastewaters using solid-phase extraction-liquid chromatography-tandem mass spectrometry.
J Sep Sci. 2012 Apr; 35(7):875-82.JS

Abstract

Four different commercial sorbents for solid-phase extraction have been evaluated for the extraction of a group of acidic pharmaceuticals in terms of selectivity and capacity: Oasis hydrophilic-lipophilic balance (HLB), Oasis MAX (strong anion exchange), Oasis WAX (weak anion exchange) and a commercial available molecularly imprinted polymer specific for non-steroidal anti-inflammatory drugs. Among the sorbents studied, molecularly imprinted polymer proved to be very effective in the reduction of matrix interferences and the selective extraction of acidic pharmaceuticals, such as salicylic acid, ibuprofen, fenoprofen, diclofenac and naproxen, among others, from effluent wastewater samples. Moreover, molecularly imprinted solid-phase extraction protocol was applied to liquid chromatography coupled to tandem mass spectrometry (MS/MS) with the purpose of evaluating the clean-up effect on ion suppression/enhancement when the complexity of the samples increases and a reduction of this effect was observed. Molecularly imprinted solid-phase extraction followed by liquid chromatography coupled to ultraviolet detection and liquid chromatography coupled to tandem mass spectrometry validation methodologies with effluent wastewaters were developed, obtaining recoveries between 70 and 85% and limits of detection at low levels of μg/L (0.15-1 μg/L) and ng/L (0.5-2 ng/L), respectively. The final application of molecularly imprinted solid-phase extraction and liquid chromatography coupled to MS/MS detection showed the presence of acidic pharmaceuticals studied in this work in effluent wastewaters (<limit of quantification-1493 ng/L).

Authors+Show Affiliations

Departament de Química Analítica i Química Orgànica,, Universitat Rovira i Virgili, Campus Sescelades, Tarragona, Spain.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22532357

Citation

Gilart, Núria, et al. "Determination of Pharmaceuticals in Wastewaters Using Solid-phase Extraction-liquid Chromatography-tandem Mass Spectrometry." Journal of Separation Science, vol. 35, no. 7, 2012, pp. 875-82.
Gilart N, Marcé RM, Borrull F, et al. Determination of pharmaceuticals in wastewaters using solid-phase extraction-liquid chromatography-tandem mass spectrometry. J Sep Sci. 2012;35(7):875-82.
Gilart, N., Marcé, R. M., Borrull, F., & Fontanals, N. (2012). Determination of pharmaceuticals in wastewaters using solid-phase extraction-liquid chromatography-tandem mass spectrometry. Journal of Separation Science, 35(7), 875-82. https://doi.org/10.1002/jssc.201101002
Gilart N, et al. Determination of Pharmaceuticals in Wastewaters Using Solid-phase Extraction-liquid Chromatography-tandem Mass Spectrometry. J Sep Sci. 2012;35(7):875-82. PubMed PMID: 22532357.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Determination of pharmaceuticals in wastewaters using solid-phase extraction-liquid chromatography-tandem mass spectrometry. AU - Gilart,Núria, AU - Marcé,Rosa Maria, AU - Borrull,Francesc, AU - Fontanals,Núria, PY - 2012/4/26/entrez PY - 2012/4/26/pubmed PY - 2012/8/9/medline SP - 875 EP - 82 JF - Journal of separation science JO - J Sep Sci VL - 35 IS - 7 N2 - Four different commercial sorbents for solid-phase extraction have been evaluated for the extraction of a group of acidic pharmaceuticals in terms of selectivity and capacity: Oasis hydrophilic-lipophilic balance (HLB), Oasis MAX (strong anion exchange), Oasis WAX (weak anion exchange) and a commercial available molecularly imprinted polymer specific for non-steroidal anti-inflammatory drugs. Among the sorbents studied, molecularly imprinted polymer proved to be very effective in the reduction of matrix interferences and the selective extraction of acidic pharmaceuticals, such as salicylic acid, ibuprofen, fenoprofen, diclofenac and naproxen, among others, from effluent wastewater samples. Moreover, molecularly imprinted solid-phase extraction protocol was applied to liquid chromatography coupled to tandem mass spectrometry (MS/MS) with the purpose of evaluating the clean-up effect on ion suppression/enhancement when the complexity of the samples increases and a reduction of this effect was observed. Molecularly imprinted solid-phase extraction followed by liquid chromatography coupled to ultraviolet detection and liquid chromatography coupled to tandem mass spectrometry validation methodologies with effluent wastewaters were developed, obtaining recoveries between 70 and 85% and limits of detection at low levels of μg/L (0.15-1 μg/L) and ng/L (0.5-2 ng/L), respectively. The final application of molecularly imprinted solid-phase extraction and liquid chromatography coupled to MS/MS detection showed the presence of acidic pharmaceuticals studied in this work in effluent wastewaters (<limit of quantification-1493 ng/L). SN - 1615-9314 UR - https://www.unboundmedicine.com/medline/citation/22532357/Determination_of_pharmaceuticals_in_wastewaters_using_solid_phase_extraction_liquid_chromatography_tandem_mass_spectrometry_ L2 - https://doi.org/10.1002/jssc.201101002 DB - PRIME DP - Unbound Medicine ER -