Tags

Type your tag names separated by a space and hit enter

Point-of-care β-hydroxybutyrate measurement for the diagnosis of feline diabetic ketoacidaemia.
J Small Anim Pract. 2012 Jun; 53(6):328-31.JS

Abstract

OBJECTIVES

To evaluate accuracy and precision of a hand-held ketone meter measuring β-hydroxybutyrate and to determine its diagnostic performance to rule out ketoacidaemia in diabetic cats.

METHODS

The ketone meter was validated by calculating within-day precision at different β-hydroxybutyrate concentrations and by comparison with a laboratory method. To determine its diagnostic performance to diagnose ketoacidaemia, 217 sets of data (venous blood gas analysis and β-hydroxybutyrate measurements) were retrospectively analysed. Sensitivities and specificities were calculated with the help of receiver-operating characteristic curves.

RESULTS

The ketone meter reliably detected β-hydroxybutyrate at concentrations >0·1 mmol/L and reproducibility was acceptable. Measurements highly correlated with laboratory results (r=0·97; P<0·001), but a significant negative bias was found at high concentrations. A β-hydroxybutyrate concentration of >2·55 mmol/L had a sensitivity of 94% and a specificity of 68% for diagnosing ketoacidaemia. Many cats with high β-hydroxybutyrate concentrations and normal blood pH had an elevated chloride gap suggestive of superimposed hypochloraemic metabolic alkalosis.

CLINICAL SIGNIFICANCE

The commercially available point-of-care ketone meter Precision Xtra is a valid tool to measure β-hydroxybutyrate in diabetic cats. Concentration <2·55 mmol/L enable ketoacidaemia to be excluded and should lead to redirection of differential diagnoses.

Authors+Show Affiliations

Clinical Department for Small Animals and Horses, University of Veterinary Medicine, Veterinaerplatz 1, Vienna, Austria.No affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

22533366

Citation

Zeugswetter, F K., and L Rebuzzi. "Point-of-care Β-hydroxybutyrate Measurement for the Diagnosis of Feline Diabetic Ketoacidaemia." The Journal of Small Animal Practice, vol. 53, no. 6, 2012, pp. 328-31.
Zeugswetter FK, Rebuzzi L. Point-of-care β-hydroxybutyrate measurement for the diagnosis of feline diabetic ketoacidaemia. J Small Anim Pract. 2012;53(6):328-31.
Zeugswetter, F. K., & Rebuzzi, L. (2012). Point-of-care β-hydroxybutyrate measurement for the diagnosis of feline diabetic ketoacidaemia. The Journal of Small Animal Practice, 53(6), 328-31. https://doi.org/10.1111/j.1748-5827.2012.01204.x
Zeugswetter FK, Rebuzzi L. Point-of-care Β-hydroxybutyrate Measurement for the Diagnosis of Feline Diabetic Ketoacidaemia. J Small Anim Pract. 2012;53(6):328-31. PubMed PMID: 22533366.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Point-of-care β-hydroxybutyrate measurement for the diagnosis of feline diabetic ketoacidaemia. AU - Zeugswetter,F K, AU - Rebuzzi,L, Y1 - 2012/04/26/ PY - 2012/4/27/entrez PY - 2012/4/27/pubmed PY - 2012/7/26/medline SP - 328 EP - 31 JF - The Journal of small animal practice JO - J Small Anim Pract VL - 53 IS - 6 N2 - OBJECTIVES: To evaluate accuracy and precision of a hand-held ketone meter measuring β-hydroxybutyrate and to determine its diagnostic performance to rule out ketoacidaemia in diabetic cats. METHODS: The ketone meter was validated by calculating within-day precision at different β-hydroxybutyrate concentrations and by comparison with a laboratory method. To determine its diagnostic performance to diagnose ketoacidaemia, 217 sets of data (venous blood gas analysis and β-hydroxybutyrate measurements) were retrospectively analysed. Sensitivities and specificities were calculated with the help of receiver-operating characteristic curves. RESULTS: The ketone meter reliably detected β-hydroxybutyrate at concentrations >0·1 mmol/L and reproducibility was acceptable. Measurements highly correlated with laboratory results (r=0·97; P<0·001), but a significant negative bias was found at high concentrations. A β-hydroxybutyrate concentration of >2·55 mmol/L had a sensitivity of 94% and a specificity of 68% for diagnosing ketoacidaemia. Many cats with high β-hydroxybutyrate concentrations and normal blood pH had an elevated chloride gap suggestive of superimposed hypochloraemic metabolic alkalosis. CLINICAL SIGNIFICANCE: The commercially available point-of-care ketone meter Precision Xtra is a valid tool to measure β-hydroxybutyrate in diabetic cats. Concentration <2·55 mmol/L enable ketoacidaemia to be excluded and should lead to redirection of differential diagnoses. SN - 1748-5827 UR - https://www.unboundmedicine.com/medline/citation/22533366/Point_of_care_β_hydroxybutyrate_measurement_for_the_diagnosis_of_feline_diabetic_ketoacidaemia_ L2 - https://doi.org/10.1111/j.1748-5827.2012.01204.x DB - PRIME DP - Unbound Medicine ER -