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Meat intake is not associated with risk of non-Hodgkin lymphoma in a large prospective cohort of U.S. men and women.
J Nutr 2012; 142(6):1074-80JN

Abstract

Meat intake has been inconsistently associated with risk of non-Hodgkin lymphoma (NHL), a heterogeneous group of malignancies of the lymphoid tissue etiologically linked to immunomodulatory factors. In a large U.S. cohort, we prospectively investigated several biologically plausible mechanisms related to meat intake, including meat-cooking and meat-processing compounds, in relation to NHL risk by histologic subtype. At baseline (1995-1996), participants of the NIH-AARP Diet and Health Study completed a diet and lifestyle questionnaire (n = 492,186), and a subcohort (n = 302,162) also completed a questionnaire on meat-cooking methods and doneness levels. Over a mean of 9 y of follow-up, we identified 3611 incident cases of NHL. In multivariable Cox proportional hazards regression models, we found no association between intake of red meat, processed meat, fish, poultry, heme iron, nitrite, nitrate, animal fat, or protein and NHL risk. MeIQx (2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline) and DiMeIQx (2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline), heterocyclic amines formed in meats cooked to well done at high temperatures, were inversely associated with chronic lymphocytic leukemia/small lymphocytic lymphoma [n = 979; HR (95% CI) for the highest vs. lowest quintile of intake: 0.73 (0.55, 0.96) and 0.77 (0.61, 0.98), respectively]. In this large U.S. cohort, meat intake was not associated with NHL or any histologic subtypes of NHL. Contrary to findings in animal models and other cancer sites, meat-cooking and -processing compounds did not increase NHL risk.

Authors+Show Affiliations

National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA. carrie.daniel@nih.hhs.govNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Intramural

Language

eng

PubMed ID

22535761

Citation

Daniel, Carrie R., et al. "Meat Intake Is Not Associated With Risk of non-Hodgkin Lymphoma in a Large Prospective Cohort of U.S. Men and Women." The Journal of Nutrition, vol. 142, no. 6, 2012, pp. 1074-80.
Daniel CR, Sinha R, Park Y, et al. Meat intake is not associated with risk of non-Hodgkin lymphoma in a large prospective cohort of U.S. men and women. J Nutr. 2012;142(6):1074-80.
Daniel, C. R., Sinha, R., Park, Y., Graubard, B. I., Hollenbeck, A. R., Morton, L. M., & Cross, A. J. (2012). Meat intake is not associated with risk of non-Hodgkin lymphoma in a large prospective cohort of U.S. men and women. The Journal of Nutrition, 142(6), pp. 1074-80. doi:10.3945/jn.112.158113.
Daniel CR, et al. Meat Intake Is Not Associated With Risk of non-Hodgkin Lymphoma in a Large Prospective Cohort of U.S. Men and Women. J Nutr. 2012;142(6):1074-80. PubMed PMID: 22535761.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Meat intake is not associated with risk of non-Hodgkin lymphoma in a large prospective cohort of U.S. men and women. AU - Daniel,Carrie R, AU - Sinha,Rashmi, AU - Park,Yikyung, AU - Graubard,Barry I, AU - Hollenbeck,Albert R, AU - Morton,Lindsay M, AU - Cross,Amanda J, Y1 - 2012/04/25/ PY - 2012/4/27/entrez PY - 2012/4/27/pubmed PY - 2012/7/26/medline SP - 1074 EP - 80 JF - The Journal of nutrition JO - J. Nutr. VL - 142 IS - 6 N2 - Meat intake has been inconsistently associated with risk of non-Hodgkin lymphoma (NHL), a heterogeneous group of malignancies of the lymphoid tissue etiologically linked to immunomodulatory factors. In a large U.S. cohort, we prospectively investigated several biologically plausible mechanisms related to meat intake, including meat-cooking and meat-processing compounds, in relation to NHL risk by histologic subtype. At baseline (1995-1996), participants of the NIH-AARP Diet and Health Study completed a diet and lifestyle questionnaire (n = 492,186), and a subcohort (n = 302,162) also completed a questionnaire on meat-cooking methods and doneness levels. Over a mean of 9 y of follow-up, we identified 3611 incident cases of NHL. In multivariable Cox proportional hazards regression models, we found no association between intake of red meat, processed meat, fish, poultry, heme iron, nitrite, nitrate, animal fat, or protein and NHL risk. MeIQx (2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline) and DiMeIQx (2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline), heterocyclic amines formed in meats cooked to well done at high temperatures, were inversely associated with chronic lymphocytic leukemia/small lymphocytic lymphoma [n = 979; HR (95% CI) for the highest vs. lowest quintile of intake: 0.73 (0.55, 0.96) and 0.77 (0.61, 0.98), respectively]. In this large U.S. cohort, meat intake was not associated with NHL or any histologic subtypes of NHL. Contrary to findings in animal models and other cancer sites, meat-cooking and -processing compounds did not increase NHL risk. SN - 1541-6100 UR - https://www.unboundmedicine.com/medline/citation/22535761/Meat_intake_is_not_associated_with_risk_of_non_Hodgkin_lymphoma_in_a_large_prospective_cohort_of_U_S__men_and_women_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.3945/jn.112.158113 DB - PRIME DP - Unbound Medicine ER -