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Meat intake is not associated with risk of non-Hodgkin lymphoma in a large prospective cohort of U.S. men and women.

Abstract

Meat intake has been inconsistently associated with risk of non-Hodgkin lymphoma (NHL), a heterogeneous group of malignancies of the lymphoid tissue etiologically linked to immunomodulatory factors. In a large U.S. cohort, we prospectively investigated several biologically plausible mechanisms related to meat intake, including meat-cooking and meat-processing compounds, in relation to NHL risk by histologic subtype. At baseline (1995-1996), participants of the NIH-AARP Diet and Health Study completed a diet and lifestyle questionnaire (n = 492,186), and a subcohort (n = 302,162) also completed a questionnaire on meat-cooking methods and doneness levels. Over a mean of 9 y of follow-up, we identified 3611 incident cases of NHL. In multivariable Cox proportional hazards regression models, we found no association between intake of red meat, processed meat, fish, poultry, heme iron, nitrite, nitrate, animal fat, or protein and NHL risk. MeIQx (2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline) and DiMeIQx (2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline), heterocyclic amines formed in meats cooked to well done at high temperatures, were inversely associated with chronic lymphocytic leukemia/small lymphocytic lymphoma [n = 979; HR (95% CI) for the highest vs. lowest quintile of intake: 0.73 (0.55, 0.96) and 0.77 (0.61, 0.98), respectively]. In this large U.S. cohort, meat intake was not associated with NHL or any histologic subtypes of NHL. Contrary to findings in animal models and other cancer sites, meat-cooking and -processing compounds did not increase NHL risk.

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  • Authors+Show Affiliations

    ,

    National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA. carrie.daniel@nih.hhs.gov

    , , , , ,

    Source

    The Journal of nutrition 142:6 2012 Jun pg 1074-80

    MeSH

    Aged
    Animals
    Cattle
    Chickens
    Cohort Studies
    Diet
    Feeding Behavior
    Female
    Food Handling
    Humans
    Lymphoma, Non-Hodgkin
    Male
    Meat
    Middle Aged
    Risk Factors
    Surveys and Questionnaires
    United States

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Intramural

    Language

    eng

    PubMed ID

    22535761

    Citation

    Daniel, Carrie R., et al. "Meat Intake Is Not Associated With Risk of non-Hodgkin Lymphoma in a Large Prospective Cohort of U.S. Men and Women." The Journal of Nutrition, vol. 142, no. 6, 2012, pp. 1074-80.
    Daniel CR, Sinha R, Park Y, et al. Meat intake is not associated with risk of non-Hodgkin lymphoma in a large prospective cohort of U.S. men and women. J Nutr. 2012;142(6):1074-80.
    Daniel, C. R., Sinha, R., Park, Y., Graubard, B. I., Hollenbeck, A. R., Morton, L. M., & Cross, A. J. (2012). Meat intake is not associated with risk of non-Hodgkin lymphoma in a large prospective cohort of U.S. men and women. The Journal of Nutrition, 142(6), pp. 1074-80. doi:10.3945/jn.112.158113.
    Daniel CR, et al. Meat Intake Is Not Associated With Risk of non-Hodgkin Lymphoma in a Large Prospective Cohort of U.S. Men and Women. J Nutr. 2012;142(6):1074-80. PubMed PMID: 22535761.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Meat intake is not associated with risk of non-Hodgkin lymphoma in a large prospective cohort of U.S. men and women. AU - Daniel,Carrie R, AU - Sinha,Rashmi, AU - Park,Yikyung, AU - Graubard,Barry I, AU - Hollenbeck,Albert R, AU - Morton,Lindsay M, AU - Cross,Amanda J, Y1 - 2012/04/25/ PY - 2012/4/27/entrez PY - 2012/4/27/pubmed PY - 2012/7/26/medline SP - 1074 EP - 80 JF - The Journal of nutrition JO - J. Nutr. VL - 142 IS - 6 N2 - Meat intake has been inconsistently associated with risk of non-Hodgkin lymphoma (NHL), a heterogeneous group of malignancies of the lymphoid tissue etiologically linked to immunomodulatory factors. In a large U.S. cohort, we prospectively investigated several biologically plausible mechanisms related to meat intake, including meat-cooking and meat-processing compounds, in relation to NHL risk by histologic subtype. At baseline (1995-1996), participants of the NIH-AARP Diet and Health Study completed a diet and lifestyle questionnaire (n = 492,186), and a subcohort (n = 302,162) also completed a questionnaire on meat-cooking methods and doneness levels. Over a mean of 9 y of follow-up, we identified 3611 incident cases of NHL. In multivariable Cox proportional hazards regression models, we found no association between intake of red meat, processed meat, fish, poultry, heme iron, nitrite, nitrate, animal fat, or protein and NHL risk. MeIQx (2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline) and DiMeIQx (2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline), heterocyclic amines formed in meats cooked to well done at high temperatures, were inversely associated with chronic lymphocytic leukemia/small lymphocytic lymphoma [n = 979; HR (95% CI) for the highest vs. lowest quintile of intake: 0.73 (0.55, 0.96) and 0.77 (0.61, 0.98), respectively]. In this large U.S. cohort, meat intake was not associated with NHL or any histologic subtypes of NHL. Contrary to findings in animal models and other cancer sites, meat-cooking and -processing compounds did not increase NHL risk. SN - 1541-6100 UR - https://www.unboundmedicine.com/medline/citation/22535761/Meat_intake_is_not_associated_with_risk_of_non_Hodgkin_lymphoma_in_a_large_prospective_cohort_of_U_S__men_and_women_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.3945/jn.112.158113 DB - PRIME DP - Unbound Medicine ER -