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A retrospective review of the effectiveness of aripiprazole in the treatment of sensory abnormalities in autism.
J Child Adolesc Psychopharmacol. 2012 Jun; 22(3):245-8.JC

Abstract

Although sensory deficits are frequently observed in autistic individuals, pharmacologic interventions targeting these abnormalities are lacking. The goal of this investigation was to assess the effectiveness of aripiprazole in targeting sensory deficits in children and adolescents with autism. Using an outpatient clinic registry for pervasive developmental disorder, 13 individuals who had received aripiprazole for treating disruptive behaviors and had completed behavioral rating scales (aberrant behavior checklist [ABC] and sensory profile questionnaire [SPQ]) were identified. Mean treatment duration was 24.4 weeks with a mean final aripiprazole dosage of 10.8 mg. Aripiprazole yielded improvements in the total ABC and in several items of the SPQ including registration, inattention/distractibility, auditory processing, and modulation of visual input affecting emotional responses and activity level, suggesting that aripiprazole might be beneficial in targeting sensory abnormalities in autism.

Authors+Show Affiliations

Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA. lkfung@stanford.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22537360

Citation

Fung, Lawrence K., et al. "A Retrospective Review of the Effectiveness of Aripiprazole in the Treatment of Sensory Abnormalities in Autism." Journal of Child and Adolescent Psychopharmacology, vol. 22, no. 3, 2012, pp. 245-8.
Fung LK, Chahal L, Libove RA, et al. A retrospective review of the effectiveness of aripiprazole in the treatment of sensory abnormalities in autism. J Child Adolesc Psychopharmacol. 2012;22(3):245-8.
Fung, L. K., Chahal, L., Libove, R. A., Bivas, R., & Hardan, A. Y. (2012). A retrospective review of the effectiveness of aripiprazole in the treatment of sensory abnormalities in autism. Journal of Child and Adolescent Psychopharmacology, 22(3), 245-8. https://doi.org/10.1089/cap.2010.0103
Fung LK, et al. A Retrospective Review of the Effectiveness of Aripiprazole in the Treatment of Sensory Abnormalities in Autism. J Child Adolesc Psychopharmacol. 2012;22(3):245-8. PubMed PMID: 22537360.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A retrospective review of the effectiveness of aripiprazole in the treatment of sensory abnormalities in autism. AU - Fung,Lawrence K, AU - Chahal,Lovina, AU - Libove,Robin A, AU - Bivas,Raphael, AU - Hardan,Antonio Y, Y1 - 2012/04/26/ PY - 2012/4/28/entrez PY - 2012/4/28/pubmed PY - 2012/11/6/medline SP - 245 EP - 8 JF - Journal of child and adolescent psychopharmacology JO - J Child Adolesc Psychopharmacol VL - 22 IS - 3 N2 - Although sensory deficits are frequently observed in autistic individuals, pharmacologic interventions targeting these abnormalities are lacking. The goal of this investigation was to assess the effectiveness of aripiprazole in targeting sensory deficits in children and adolescents with autism. Using an outpatient clinic registry for pervasive developmental disorder, 13 individuals who had received aripiprazole for treating disruptive behaviors and had completed behavioral rating scales (aberrant behavior checklist [ABC] and sensory profile questionnaire [SPQ]) were identified. Mean treatment duration was 24.4 weeks with a mean final aripiprazole dosage of 10.8 mg. Aripiprazole yielded improvements in the total ABC and in several items of the SPQ including registration, inattention/distractibility, auditory processing, and modulation of visual input affecting emotional responses and activity level, suggesting that aripiprazole might be beneficial in targeting sensory abnormalities in autism. SN - 1557-8992 UR - https://www.unboundmedicine.com/medline/citation/22537360/A_retrospective_review_of_the_effectiveness_of_aripiprazole_in_the_treatment_of_sensory_abnormalities_in_autism_ L2 - https://www.liebertpub.com/doi/10.1089/cap.2010.0103?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -