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Inhibitory effect of β-sitosterol on TNBS-induced colitis in mice.
Planta Med. 2012 Jun; 78(9):896-8.PM

Abstract

β-Sitosterol, a common sterol in herbal medicines, exhibits anti-inflammatory effects beneficial in the treatment of lung inflammation, asthma, and bronchospasm. To evaluate whether β-sitosterol also has anticolitic benefits, we tested the effect of β-sitosterol on 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis in mice. β-Sitosterol inhibited colon shortening and led to lowered macroscopic scores and myeloperoxidase activity in TNBS-treated colitic mice. β-Sitosterol also inhibited the expression of proinflammatory cytokines TNF-α, IL-1β, and IL-6, and an inflammatory enzyme, cyclooxygenase (COX)-2, in the colons of TNBS-induced colitic mice, as well as the activation of NF-κB. Based on these findings, β-sitosterol may ameliorate colitis by inhibiting the NF-κB pathway.

Authors+Show Affiliations

Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, Seoul, Korea.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22538477

Citation

Lee, In-Ah, et al. "Inhibitory Effect of Β-sitosterol On TNBS-induced Colitis in Mice." Planta Medica, vol. 78, no. 9, 2012, pp. 896-8.
Lee IA, Kim EJ, Kim DH. Inhibitory effect of β-sitosterol on TNBS-induced colitis in mice. Planta Med. 2012;78(9):896-8.
Lee, I. A., Kim, E. J., & Kim, D. H. (2012). Inhibitory effect of β-sitosterol on TNBS-induced colitis in mice. Planta Medica, 78(9), 896-8. https://doi.org/10.1055/s-0031-1298486
Lee IA, Kim EJ, Kim DH. Inhibitory Effect of Β-sitosterol On TNBS-induced Colitis in Mice. Planta Med. 2012;78(9):896-8. PubMed PMID: 22538477.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhibitory effect of β-sitosterol on TNBS-induced colitis in mice. AU - Lee,In-Ah, AU - Kim,Eun-Jin, AU - Kim,Dong-Hyun, Y1 - 2012/04/26/ PY - 2012/4/28/entrez PY - 2012/4/28/pubmed PY - 2012/10/27/medline SP - 896 EP - 8 JF - Planta medica JO - Planta Med VL - 78 IS - 9 N2 - β-Sitosterol, a common sterol in herbal medicines, exhibits anti-inflammatory effects beneficial in the treatment of lung inflammation, asthma, and bronchospasm. To evaluate whether β-sitosterol also has anticolitic benefits, we tested the effect of β-sitosterol on 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis in mice. β-Sitosterol inhibited colon shortening and led to lowered macroscopic scores and myeloperoxidase activity in TNBS-treated colitic mice. β-Sitosterol also inhibited the expression of proinflammatory cytokines TNF-α, IL-1β, and IL-6, and an inflammatory enzyme, cyclooxygenase (COX)-2, in the colons of TNBS-induced colitic mice, as well as the activation of NF-κB. Based on these findings, β-sitosterol may ameliorate colitis by inhibiting the NF-κB pathway. SN - 1439-0221 UR - https://www.unboundmedicine.com/medline/citation/22538477/Inhibitory_effect_of_β_sitosterol_on_TNBS_induced_colitis_in_mice_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-0031-1298486 DB - PRIME DP - Unbound Medicine ER -