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Synthesis of N-alkoxycarbonyl ketimines derived from isatins and their application in enantioselective synthesis of 3-aminooxindoles.
Org Lett. 2012 May 18; 14(10):2512-5.OL

Abstract

A simple and general method in the synthesis of N-alkoxycarbonyl ketimines derived from isatins has been described first. Generally, the enantioselective addition of 1,3-dicarbonyl compounds to this kind of ketimine affords chiral 3-amino oxindoles in high yield and excellent ee.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Yan W
Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, State Key Laboratory of Applied Organic Chemistry and Institute of Biochemistry and Molecular Biology, Lanzhou University , Lanzhou, 730000, China.
Wang D
No affiliation info available
Feng J
No affiliation info available
Li P
No affiliation info available
Zhao D
No affiliation info available
Wang R
No affiliation info available

MeSH

CatalysisIminesIndolesIsatinMolecular StructureNitrilesOxindolesStereoisomerism

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22540839

Citation

Yan, Wenjin, et al. "Synthesis of N-alkoxycarbonyl Ketimines Derived From Isatins and Their Application in Enantioselective Synthesis of 3-aminooxindoles." Organic Letters, vol. 14, no. 10, 2012, pp. 2512-5.
Yan W, Wang D, Feng J, et al. Synthesis of N-alkoxycarbonyl ketimines derived from isatins and their application in enantioselective synthesis of 3-aminooxindoles. Org Lett. 2012;14(10):2512-5.
Yan, W., Wang, D., Feng, J., Li, P., Zhao, D., & Wang, R. (2012). Synthesis of N-alkoxycarbonyl ketimines derived from isatins and their application in enantioselective synthesis of 3-aminooxindoles. Organic Letters, 14(10), 2512-5. https://doi.org/10.1021/ol3007953
Yan W, et al. Synthesis of N-alkoxycarbonyl Ketimines Derived From Isatins and Their Application in Enantioselective Synthesis of 3-aminooxindoles. Org Lett. 2012 May 18;14(10):2512-5. PubMed PMID: 22540839.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synthesis of N-alkoxycarbonyl ketimines derived from isatins and their application in enantioselective synthesis of 3-aminooxindoles. AU - Yan,Wenjin, AU - Wang,Dong, AU - Feng,Jingchao, AU - Li,Peng, AU - Zhao,Depeng, AU - Wang,Rui, Y1 - 2012/04/27/ PY - 2012/5/1/entrez PY - 2012/5/1/pubmed PY - 2014/4/26/medline SP - 2512 EP - 5 JF - Organic letters JO - Org Lett VL - 14 IS - 10 N2 - A simple and general method in the synthesis of N-alkoxycarbonyl ketimines derived from isatins has been described first. Generally, the enantioselective addition of 1,3-dicarbonyl compounds to this kind of ketimine affords chiral 3-amino oxindoles in high yield and excellent ee. SN - 1523-7052 UR - https://www.unboundmedicine.com/medline/citation/22540839/Synthesis_of_N_alkoxycarbonyl_ketimines_derived_from_isatins_and_their_application_in_enantioselective_synthesis_of_3_aminooxindoles_ L2 - https://doi.org/10.1021/ol3007953 DB - PRIME DP - Unbound Medicine ER -