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Four-year incidence of open-angle glaucoma and ocular hypertension: the Los Angeles Latino Eye Study.
Am J Ophthalmol 2012; 154(2):315-325.e1AJ

Abstract

PURPOSE

To estimate the 4-year incidence of open-angle glaucoma (OAG) and ocular hypertension (OHT) among adult Latinos 40 years of age and older.

DESIGN

Population-based longitudinal study.

METHODS

Comprehensive ophthalmologic examinations including intraocular pressure, visual field testing, and stereoscopic fundus photography were performed at both baseline and the 4-year follow-up examination. Incident OAG at the 4-year follow-up examination was defined as the presence of an open angle and a glaucomatous visual field abnormality or evidence of glaucomatous optic disc damage, or both when not present at baseline. Incident OHT was defined as intraocular pressure of more than 21 mm Hg and the absence of optic disc damage or abnormal visual field results at the 4 year follow-up examination when not present at baseline.

RESULTS

Among the 3939 participants (mean age, 54.7 ± 10.5 years) with complete data for a diagnosis of glaucoma at both baseline and follow-up examination, incident OAG at the 4-year follow-up was identified in 87 persons (4-year incidence rate, 2.3%; 95% confidence interval, 1.8% to 2.8%). Incident OHT at the 4-year follow-up was identified in 124 persons (4-year incidence rate, 3.5%; 95% confidence interval, 2.9% to 4.1%). In participants with OAG in 1 eye, the 4-year risk of OAG developing in the fellow eye was 5 times as high as the risk for those without OAG in either eye at baseline. In participants with OHT in 1 eye, the 4-year risk of OHT developing in the fellow eye was 10 times as high as the risk for those without OHT in either eye at baseline. The incidence rates of OAG and OHT were higher in older Latinos than in younger Latinos.

CONCLUSIONS

Incidence of OAG in Latinos is higher than in non-Hispanic whites, but lower than in Afro-Caribbeans. The relatively high rate of incident OAG and OHT underscores the need for community screening programs in this fastest growing segment of the United States population.

Authors+Show Affiliations

Doheny Eye Institute and the Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA. rvarma@usc.edu

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22541649

Citation

Varma, Rohit, et al. "Four-year Incidence of Open-angle Glaucoma and Ocular Hypertension: the Los Angeles Latino Eye Study." American Journal of Ophthalmology, vol. 154, no. 2, 2012, pp. 315-325.e1.
Varma R, Wang D, Wu C, et al. Four-year incidence of open-angle glaucoma and ocular hypertension: the Los Angeles Latino Eye Study. Am J Ophthalmol. 2012;154(2):315-325.e1.
Varma, R., Wang, D., Wu, C., Francis, B. A., Nguyen, B. B., Chopra, V., ... Azen, S. P. (2012). Four-year incidence of open-angle glaucoma and ocular hypertension: the Los Angeles Latino Eye Study. American Journal of Ophthalmology, 154(2), pp. 315-325.e1. doi:10.1016/j.ajo.2012.02.014.
Varma R, et al. Four-year Incidence of Open-angle Glaucoma and Ocular Hypertension: the Los Angeles Latino Eye Study. Am J Ophthalmol. 2012;154(2):315-325.e1. PubMed PMID: 22541649.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Four-year incidence of open-angle glaucoma and ocular hypertension: the Los Angeles Latino Eye Study. AU - Varma,Rohit, AU - Wang,Dandan, AU - Wu,Cathy, AU - Francis,Brian A, AU - Nguyen,Betsy Bao-Thu, AU - Chopra,Vikas, AU - Memarzadeh,Farnaz, AU - Torres,Mina, AU - Azen,Stanley P, AU - ,, Y1 - 2012/04/27/ PY - 2011/10/04/received PY - 2012/02/08/revised PY - 2012/02/09/accepted PY - 2012/5/1/entrez PY - 2012/5/1/pubmed PY - 2012/10/17/medline SP - 315 EP - 325.e1 JF - American journal of ophthalmology JO - Am. J. Ophthalmol. VL - 154 IS - 2 N2 - PURPOSE: To estimate the 4-year incidence of open-angle glaucoma (OAG) and ocular hypertension (OHT) among adult Latinos 40 years of age and older. DESIGN: Population-based longitudinal study. METHODS: Comprehensive ophthalmologic examinations including intraocular pressure, visual field testing, and stereoscopic fundus photography were performed at both baseline and the 4-year follow-up examination. Incident OAG at the 4-year follow-up examination was defined as the presence of an open angle and a glaucomatous visual field abnormality or evidence of glaucomatous optic disc damage, or both when not present at baseline. Incident OHT was defined as intraocular pressure of more than 21 mm Hg and the absence of optic disc damage or abnormal visual field results at the 4 year follow-up examination when not present at baseline. RESULTS: Among the 3939 participants (mean age, 54.7 ± 10.5 years) with complete data for a diagnosis of glaucoma at both baseline and follow-up examination, incident OAG at the 4-year follow-up was identified in 87 persons (4-year incidence rate, 2.3%; 95% confidence interval, 1.8% to 2.8%). Incident OHT at the 4-year follow-up was identified in 124 persons (4-year incidence rate, 3.5%; 95% confidence interval, 2.9% to 4.1%). In participants with OAG in 1 eye, the 4-year risk of OAG developing in the fellow eye was 5 times as high as the risk for those without OAG in either eye at baseline. In participants with OHT in 1 eye, the 4-year risk of OHT developing in the fellow eye was 10 times as high as the risk for those without OHT in either eye at baseline. The incidence rates of OAG and OHT were higher in older Latinos than in younger Latinos. CONCLUSIONS: Incidence of OAG in Latinos is higher than in non-Hispanic whites, but lower than in Afro-Caribbeans. The relatively high rate of incident OAG and OHT underscores the need for community screening programs in this fastest growing segment of the United States population. SN - 1879-1891 UR - https://www.unboundmedicine.com/medline/citation/22541649/Four_year_incidence_of_open_angle_glaucoma_and_ocular_hypertension:_the_Los_Angeles_Latino_Eye_Study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9394(12)00118-3 DB - PRIME DP - Unbound Medicine ER -