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Antidiabetic effect of S-allylcysteine: effect on thyroid hormone and circulatory antioxidant system in experimental diabetic rats.
J Diabetes Complications. 2012 Jul-Aug; 26(4):280-5.JD

Abstract

OBJECTIVE

It is considered that diabetes mellitus and thyroid disease are the two common endocrine disorders and also suggested that insulin and thyroid hormones influence each other actions. The present study was designed to investigate the effect of the administration of S-allylcysteine (SAC), a sulfur containing amino acid derived from garlic on blood glucose, insulin, HbA1C, total protein, albumin, Thyroid hormone (T3, T4), TSH, TBARS and circulatory antioxidant levels (SOD, CAT, GSH and GPx) in STZ-induced diabetic rats.

METHODS

SAC was administered orally for 45 days to control and STZ induced diabetic rats. The effects of SAC on glucose, plasma insulin, HbA1C, total protein, albumin, Thyroid hormone, TSH and circulatory antioxidant levels were studied.

RESULTS

The levels of glucose, TBARS, hydroperoxide and HbA1C were increased significantly whereas the levels of plasma insulin, reduced glutathione, superoxide dismutase, catalase, GSH, GPx, total protein, albumin, Thyroid hormone and TSH were decreased in STZ induced diabetic rats. Administration of SAC to diabetic rats showed a decrease in plasma glucose, TBARS, hydroperoxide and HbA1C. In addition, the levels of plasma insulin, SOD, CAT, GPx, GSH, total protein, albumin, Thyroid hormone and TSH were increased in SAC treated diabetic rats. The effect of SAC was compared with gliclazide, a well-known antioxidant and antihyperglycemic drug.

CONCLUSION

From these findings, it is indicated that SAC might be acting through activation in the synthesis and/or secretion of circulating thyroid hormones which in turn stimulate the synthesis of insulin.

Authors+Show Affiliations

Department of Biochemistry, Centre for Biological science, K.S. Rangasamy College of Arts and Science, Thokkavadi, Tiruchengode, Tamil Nadu, 637215, India. saravana_bioc@rediffmail.comNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

22541895

Citation

Saravanan, Ganapathy, and Ponnusamy Ponmurugan. "Antidiabetic Effect of S-allylcysteine: Effect On Thyroid Hormone and Circulatory Antioxidant System in Experimental Diabetic Rats." Journal of Diabetes and Its Complications, vol. 26, no. 4, 2012, pp. 280-5.
Saravanan G, Ponmurugan P. Antidiabetic effect of S-allylcysteine: effect on thyroid hormone and circulatory antioxidant system in experimental diabetic rats. J Diabetes Complications. 2012;26(4):280-5.
Saravanan, G., & Ponmurugan, P. (2012). Antidiabetic effect of S-allylcysteine: effect on thyroid hormone and circulatory antioxidant system in experimental diabetic rats. Journal of Diabetes and Its Complications, 26(4), 280-5. https://doi.org/10.1016/j.jdiacomp.2012.03.024
Saravanan G, Ponmurugan P. Antidiabetic Effect of S-allylcysteine: Effect On Thyroid Hormone and Circulatory Antioxidant System in Experimental Diabetic Rats. J Diabetes Complications. 2012 Jul-Aug;26(4):280-5. PubMed PMID: 22541895.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antidiabetic effect of S-allylcysteine: effect on thyroid hormone and circulatory antioxidant system in experimental diabetic rats. AU - Saravanan,Ganapathy, AU - Ponmurugan,Ponnusamy, Y1 - 2012/04/26/ PY - 2011/10/27/received PY - 2012/03/01/revised PY - 2012/03/03/accepted PY - 2012/5/1/entrez PY - 2012/5/1/pubmed PY - 2013/1/15/medline SP - 280 EP - 5 JF - Journal of diabetes and its complications JO - J Diabetes Complications VL - 26 IS - 4 N2 - OBJECTIVE: It is considered that diabetes mellitus and thyroid disease are the two common endocrine disorders and also suggested that insulin and thyroid hormones influence each other actions. The present study was designed to investigate the effect of the administration of S-allylcysteine (SAC), a sulfur containing amino acid derived from garlic on blood glucose, insulin, HbA1C, total protein, albumin, Thyroid hormone (T3, T4), TSH, TBARS and circulatory antioxidant levels (SOD, CAT, GSH and GPx) in STZ-induced diabetic rats. METHODS: SAC was administered orally for 45 days to control and STZ induced diabetic rats. The effects of SAC on glucose, plasma insulin, HbA1C, total protein, albumin, Thyroid hormone, TSH and circulatory antioxidant levels were studied. RESULTS: The levels of glucose, TBARS, hydroperoxide and HbA1C were increased significantly whereas the levels of plasma insulin, reduced glutathione, superoxide dismutase, catalase, GSH, GPx, total protein, albumin, Thyroid hormone and TSH were decreased in STZ induced diabetic rats. Administration of SAC to diabetic rats showed a decrease in plasma glucose, TBARS, hydroperoxide and HbA1C. In addition, the levels of plasma insulin, SOD, CAT, GPx, GSH, total protein, albumin, Thyroid hormone and TSH were increased in SAC treated diabetic rats. The effect of SAC was compared with gliclazide, a well-known antioxidant and antihyperglycemic drug. CONCLUSION: From these findings, it is indicated that SAC might be acting through activation in the synthesis and/or secretion of circulating thyroid hormones which in turn stimulate the synthesis of insulin. SN - 1873-460X UR - https://www.unboundmedicine.com/medline/citation/22541895/Antidiabetic_effect_of_S_allylcysteine:_effect_on_thyroid_hormone_and_circulatory_antioxidant_system_in_experimental_diabetic_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1056-8727(12)00064-5 DB - PRIME DP - Unbound Medicine ER -