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Effects of age and splenectomy on heavy infection of Angiostrongylus cantonensis in rats.
Exp Parasitol. 2012 Jun; 131(2):210-4.EP

Abstract

This study was designed to determine the effects of age and the role of spleen in rats with heavy Angiostrongylus cantonensis infection. Young rats (8 weeks) infected with 100 larvae were found to have significantly higher worm recovery rate (75.0±6.6%) than the adult (6 months) (55.7±1.5%) and the aging ones (13 months) (57.6±4.0%). Moreover, the recovery rate in adult rats with 400 larvae (33.6±10.67%) was significantly lower than those with 100 larvae (55.7±1.53%) or 200 larvae (53.3±5.4%). The splenectomized young rats with 100 larvae had a significantly higher recovery rate (84.3±2.5%) than the intact (75.0±6.6%) or sham splenectomized ones (74.4±3.8%). Although titers of antibody against A. cantonensis increased with time, those against young adults were significantly higher before week 4 whereas those against adult worms become significantly higher since week 4. Titers in the splenectomized rats were also found to be significantly lower than those in the intact ones. These finding indicate that young rats are more susceptible to A. cantonensis. Crowding effect may occur in rats with heavy infections. The effects of splenectomy on the host are independent of the intensity of infection.

Authors+Show Affiliations

Department of Parasitology, College of Medicine, Chang Gung University, Tao-Yuan 333, Taiwan. wanglc@mail.cgu.edu.twNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22542800

Citation

Wang, Lian-Chen, et al. "Effects of Age and Splenectomy On Heavy Infection of Angiostrongylus Cantonensis in Rats." Experimental Parasitology, vol. 131, no. 2, 2012, pp. 210-4.
Wang LC, Yen CM, Liu CL, et al. Effects of age and splenectomy on heavy infection of Angiostrongylus cantonensis in rats. Exp Parasitol. 2012;131(2):210-4.
Wang, L. C., Yen, C. M., Liu, C. L., Chen, E. R., & Chao, D. (2012). Effects of age and splenectomy on heavy infection of Angiostrongylus cantonensis in rats. Experimental Parasitology, 131(2), 210-4. https://doi.org/10.1016/j.exppara.2012.04.004
Wang LC, et al. Effects of Age and Splenectomy On Heavy Infection of Angiostrongylus Cantonensis in Rats. Exp Parasitol. 2012;131(2):210-4. PubMed PMID: 22542800.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of age and splenectomy on heavy infection of Angiostrongylus cantonensis in rats. AU - Wang,Lian-Chen, AU - Yen,Chuan-Min, AU - Liu,Chao-Lin, AU - Chen,Eng-Rin, AU - Chao,David, Y1 - 2012/04/20/ PY - 2011/09/23/received PY - 2012/04/06/revised PY - 2012/04/09/accepted PY - 2012/5/1/entrez PY - 2012/5/1/pubmed PY - 2012/7/21/medline SP - 210 EP - 4 JF - Experimental parasitology JO - Exp Parasitol VL - 131 IS - 2 N2 - This study was designed to determine the effects of age and the role of spleen in rats with heavy Angiostrongylus cantonensis infection. Young rats (8 weeks) infected with 100 larvae were found to have significantly higher worm recovery rate (75.0±6.6%) than the adult (6 months) (55.7±1.5%) and the aging ones (13 months) (57.6±4.0%). Moreover, the recovery rate in adult rats with 400 larvae (33.6±10.67%) was significantly lower than those with 100 larvae (55.7±1.53%) or 200 larvae (53.3±5.4%). The splenectomized young rats with 100 larvae had a significantly higher recovery rate (84.3±2.5%) than the intact (75.0±6.6%) or sham splenectomized ones (74.4±3.8%). Although titers of antibody against A. cantonensis increased with time, those against young adults were significantly higher before week 4 whereas those against adult worms become significantly higher since week 4. Titers in the splenectomized rats were also found to be significantly lower than those in the intact ones. These finding indicate that young rats are more susceptible to A. cantonensis. Crowding effect may occur in rats with heavy infections. The effects of splenectomy on the host are independent of the intensity of infection. SN - 1090-2449 UR - https://www.unboundmedicine.com/medline/citation/22542800/Effects_of_age_and_splenectomy_on_heavy_infection_of_Angiostrongylus_cantonensis_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-4894(12)00122-1 DB - PRIME DP - Unbound Medicine ER -