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Ophthalmologic outcomes after chemotherapy and/or radiotherapy in non-conjunctival ocular adnexal MALT lymphoma.
Ann Hematol 2012; 91(9):1393-401AH

Abstract

In the present study, we evaluated the ophthalmologic outcomes of 24 patients who received chemotherapy and/or radiotherapy for the treatment of non-conjunctival ocular adnexal mucosa-associated lymphoid tissue-type (MALT) lymphoma. Ophthalmologic outcomes were assessed in patients who received chemotherapy and/or radiotherapy from March 2004 until May 2010. Outcomes were determined according to common symptoms following chemotherapy and/or radiotherapy, which consisted of decreased visual acuity, dry eye symptoms, retinopathy, optic neuropathy, increased intraocular pressure, and blepharitis. Nine patients received chemotherapy alone, eight patients received radiotherapy alone, and seven patients received chemotherapy with additional radiotherapy (chemoradiation therapy). Patients treated by chemotherapy alone showed better ophthalmologic outcome scores (mean score, 1.56) than those treated by radiation alone or chemoradiation therapy (mean score, 4.01). In conclusion, the treatment of ocular adnexal lymphoma including radiotherapy showed poor ophthalmologic outcomes due to radiation-induced complications. Recently, many new treatment options have emerged, such as immunotherapy or radioimmunotherapy. In the future study, to select a better treatment modality with fewer complications, well-designed prospective trials with ophthalmologic outcomes are needed.

Authors+Show Affiliations

Department of Ophthalmology and Visual Science, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, 505 Banpo-dong, Seocho-ku, Seoul, 137-701, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Studies
Journal Article

Language

eng

PubMed ID

22543827

Citation

Paik, Ji-Sun, et al. "Ophthalmologic Outcomes After Chemotherapy And/or Radiotherapy in Non-conjunctival Ocular Adnexal MALT Lymphoma." Annals of Hematology, vol. 91, no. 9, 2012, pp. 1393-401.
Paik JS, Cho WK, Lee SE, et al. Ophthalmologic outcomes after chemotherapy and/or radiotherapy in non-conjunctival ocular adnexal MALT lymphoma. Ann Hematol. 2012;91(9):1393-401.
Paik, J. S., Cho, W. K., Lee, S. E., Choi, B. O., Jung, S. E., Park, G. S., ... Cho, S. G. (2012). Ophthalmologic outcomes after chemotherapy and/or radiotherapy in non-conjunctival ocular adnexal MALT lymphoma. Annals of Hematology, 91(9), pp. 1393-401. doi:10.1007/s00277-012-1469-3.
Paik JS, et al. Ophthalmologic Outcomes After Chemotherapy And/or Radiotherapy in Non-conjunctival Ocular Adnexal MALT Lymphoma. Ann Hematol. 2012;91(9):1393-401. PubMed PMID: 22543827.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ophthalmologic outcomes after chemotherapy and/or radiotherapy in non-conjunctival ocular adnexal MALT lymphoma. AU - Paik,Ji-Sun, AU - Cho,Won-Kyung, AU - Lee,Sung-Eun, AU - Choi,Byung-Ock, AU - Jung,Seung-Eun, AU - Park,Gyeong-Sin, AU - Kim,Sung-Hoon, AU - Yang,Suk-Woo, AU - Cho,Seok-Goo, Y1 - 2012/04/29/ PY - 2011/11/09/received PY - 2012/04/02/accepted PY - 2012/5/1/entrez PY - 2012/5/1/pubmed PY - 2012/10/24/medline SP - 1393 EP - 401 JF - Annals of hematology JO - Ann. Hematol. VL - 91 IS - 9 N2 - In the present study, we evaluated the ophthalmologic outcomes of 24 patients who received chemotherapy and/or radiotherapy for the treatment of non-conjunctival ocular adnexal mucosa-associated lymphoid tissue-type (MALT) lymphoma. Ophthalmologic outcomes were assessed in patients who received chemotherapy and/or radiotherapy from March 2004 until May 2010. Outcomes were determined according to common symptoms following chemotherapy and/or radiotherapy, which consisted of decreased visual acuity, dry eye symptoms, retinopathy, optic neuropathy, increased intraocular pressure, and blepharitis. Nine patients received chemotherapy alone, eight patients received radiotherapy alone, and seven patients received chemotherapy with additional radiotherapy (chemoradiation therapy). Patients treated by chemotherapy alone showed better ophthalmologic outcome scores (mean score, 1.56) than those treated by radiation alone or chemoradiation therapy (mean score, 4.01). In conclusion, the treatment of ocular adnexal lymphoma including radiotherapy showed poor ophthalmologic outcomes due to radiation-induced complications. Recently, many new treatment options have emerged, such as immunotherapy or radioimmunotherapy. In the future study, to select a better treatment modality with fewer complications, well-designed prospective trials with ophthalmologic outcomes are needed. SN - 1432-0584 UR - https://www.unboundmedicine.com/medline/citation/22543827/Ophthalmologic_outcomes_after_chemotherapy_and/or_radiotherapy_in_non_conjunctival_ocular_adnexal_MALT_lymphoma_ L2 - https://dx.doi.org/10.1007/s00277-012-1469-3 DB - PRIME DP - Unbound Medicine ER -