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Dietary intakes of vitamin E, vitamin C, and β-carotene and risk of Alzheimer's disease: a meta-analysis.
J Alzheimers Dis 2012; 31(2):253-8JA

Abstract

In view of the vital role of oxidative stress in the pathogenesis of Alzheimer's disease (AD), the potential of antioxidant supplements to prevent AD have gained much interest, while there are conflicting results on this topic in recent years. The purpose of the present study is to comprehensively evaluate the association between dietary intakes, instead of supplements, of the most common three antioxidants (vitamin E, vitamin C, and β-carotene) and the risk of AD on the basis of the meta-analysis studies published up to October 2011 in Medline and Scopus databases. In total, seven articles were included in the meta-analysis. According to the pooled relative risk [(95% CI) 0.76 (0.67-0.84) for vitamin E, 0.83 (0.72-0.94) for vitamin C, and 0.88 (0.73-1.03) for β-carotene], dietary intakes of the three antioxidants can lower the risk of AD, with vitamin E exhibiting the most pronounced protective effects. The findings will be of significance to the prevention and interventional treatment of AD.

Authors+Show Affiliations

Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Shandong University of Technology, Zibo, PR China.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22543848

Citation

Li, Feng-Jiao, et al. "Dietary Intakes of Vitamin E, Vitamin C, and Β-carotene and Risk of Alzheimer's Disease: a Meta-analysis." Journal of Alzheimer's Disease : JAD, vol. 31, no. 2, 2012, pp. 253-8.
Li FJ, Shen L, Ji HF. Dietary intakes of vitamin E, vitamin C, and β-carotene and risk of Alzheimer's disease: a meta-analysis. J Alzheimers Dis. 2012;31(2):253-8.
Li, F. J., Shen, L., & Ji, H. F. (2012). Dietary intakes of vitamin E, vitamin C, and β-carotene and risk of Alzheimer's disease: a meta-analysis. Journal of Alzheimer's Disease : JAD, 31(2), pp. 253-8. doi:10.3233/JAD-2012-120349.
Li FJ, Shen L, Ji HF. Dietary Intakes of Vitamin E, Vitamin C, and Β-carotene and Risk of Alzheimer's Disease: a Meta-analysis. J Alzheimers Dis. 2012;31(2):253-8. PubMed PMID: 22543848.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary intakes of vitamin E, vitamin C, and β-carotene and risk of Alzheimer's disease: a meta-analysis. AU - Li,Feng-Jiao, AU - Shen,Liang, AU - Ji,Hong-Fang, PY - 2012/5/1/entrez PY - 2012/5/1/pubmed PY - 2013/6/5/medline SP - 253 EP - 8 JF - Journal of Alzheimer's disease : JAD JO - J. Alzheimers Dis. VL - 31 IS - 2 N2 - In view of the vital role of oxidative stress in the pathogenesis of Alzheimer's disease (AD), the potential of antioxidant supplements to prevent AD have gained much interest, while there are conflicting results on this topic in recent years. The purpose of the present study is to comprehensively evaluate the association between dietary intakes, instead of supplements, of the most common three antioxidants (vitamin E, vitamin C, and β-carotene) and the risk of AD on the basis of the meta-analysis studies published up to October 2011 in Medline and Scopus databases. In total, seven articles were included in the meta-analysis. According to the pooled relative risk [(95% CI) 0.76 (0.67-0.84) for vitamin E, 0.83 (0.72-0.94) for vitamin C, and 0.88 (0.73-1.03) for β-carotene], dietary intakes of the three antioxidants can lower the risk of AD, with vitamin E exhibiting the most pronounced protective effects. The findings will be of significance to the prevention and interventional treatment of AD. SN - 1875-8908 UR - https://www.unboundmedicine.com/medline/citation/22543848/Dietary_intakes_of_vitamin_E_vitamin_C_and_β_carotene_and_risk_of_Alzheimer's_disease:_a_meta_analysis_ L2 - https://content.iospress.com/openurl?genre=article&id=doi:10.3233/JAD-2012-120349 DB - PRIME DP - Unbound Medicine ER -