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Two new antimicrobial metabolites from the endophytic fungus, Seimatosporium sp.
Nat Prod Commun. 2012 Mar; 7(3):293-4.NP

Abstract

Two new acaranoic acids, named seimatoporic acid A and B (1, and 2), together with six known compounds, R-(-)-mellein (3), cis-4-hydroxymellein (4), trans-4-hydroxymellein (5), 4R-hydroxy-5-methylmellein (6), (-)-5-hydroxymethylmellein (7), and ergosterol (8) were isolated from an endophytic fungus, Seimatosporium sp, by a bioassay-guided procedure. The structures of the new compounds have been assigned from analysis of the 1H and 13C NMR spectra, DEPT, and by 2D COSY, HMQC, HMBC and NOESY experiments. A mixture of compounds 1 and 2 showed strong antifungal activity against Botrytis cinerea, Septoria tritici, and Pyricularia oryzae.

Authors+Show Affiliations

Hussain H
Department Chemie, Universität Paderborn, Warburger Strasse 100, 33098 Paderborn, Germany.
Krohn K
No affiliation info available
Schulz B
No affiliation info available
Draeger S
No affiliation info available
Nazir M
No affiliation info available
Saleem M
No affiliation info available

MeSH

Anti-Infective AgentsEndophytesEpilobiumIsocoumarinsMicrobial Sensitivity TestsXylariales

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22545398

Citation

Hussain, Hidayat, et al. "Two New Antimicrobial Metabolites From the Endophytic Fungus, Seimatosporium Sp." Natural Product Communications, vol. 7, no. 3, 2012, pp. 293-4.
Hussain H, Krohn K, Schulz B, et al. Two new antimicrobial metabolites from the endophytic fungus, Seimatosporium sp. Nat Prod Commun. 2012;7(3):293-4.
Hussain, H., Krohn, K., Schulz, B., Draeger, S., Nazir, M., & Saleem, M. (2012). Two new antimicrobial metabolites from the endophytic fungus, Seimatosporium sp. Natural Product Communications, 7(3), 293-4.
Hussain H, et al. Two New Antimicrobial Metabolites From the Endophytic Fungus, Seimatosporium Sp. Nat Prod Commun. 2012;7(3):293-4. PubMed PMID: 22545398.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Two new antimicrobial metabolites from the endophytic fungus, Seimatosporium sp. AU - Hussain,Hidayat, AU - Krohn,Karsten, AU - Schulz,Barbara, AU - Draeger,Siegfried, AU - Nazir,Mamona, AU - Saleem,Muhammad, PY - 2012/5/2/entrez PY - 2012/5/2/pubmed PY - 2012/5/19/medline SP - 293 EP - 4 JF - Natural product communications JO - Nat Prod Commun VL - 7 IS - 3 N2 - Two new acaranoic acids, named seimatoporic acid A and B (1, and 2), together with six known compounds, R-(-)-mellein (3), cis-4-hydroxymellein (4), trans-4-hydroxymellein (5), 4R-hydroxy-5-methylmellein (6), (-)-5-hydroxymethylmellein (7), and ergosterol (8) were isolated from an endophytic fungus, Seimatosporium sp, by a bioassay-guided procedure. The structures of the new compounds have been assigned from analysis of the 1H and 13C NMR spectra, DEPT, and by 2D COSY, HMQC, HMBC and NOESY experiments. A mixture of compounds 1 and 2 showed strong antifungal activity against Botrytis cinerea, Septoria tritici, and Pyricularia oryzae. SN - 1934-578X UR - https://www.unboundmedicine.com/medline/citation/22545398/Two_new_antimicrobial_metabolites_from_the_endophytic_fungus_Seimatosporium_sp_ DB - PRIME DP - Unbound Medicine ER -