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The triterpenoid fraction from Trichosanthes dioica root exhibits antiproliferative activity against Ehrlich ascites carcinoma in albino mice: involvement of possible antioxidant role.

Abstract

The present study assessed the triterpenoid fraction from T dioica root (CETD) for antiproliferative effect and antioxidant influence against Ehrlich ascites carcinoma (EAC) in Swiss albino mice. Twenty-four hours after intraperitoneal inoculation of tumor (EAC) cells in mice, CETD was administered at 2 and 4 mg/ kg body weight daily for 9 consecutive days. On the 10th day, half of the mice were sacrificed for estimation of tumor proliferation, haematological, and hepatic antioxidative parameters viz. lipid peroxidation, reduced glutathione (GSH), glutathione-S-transferase (GST), superoxide dismutase(SOD)and catalase (CAT); the rest were kept alive for assessment of survival parameters. The antiproliferative effect of CETD was assessed by evaluating tumor weight, tumor volume, packed cell volume, viable and non-viable tumor cell counts, mean survival time and percentage increase in life span of EAC-bearing mice. CETD exhibited dose dependent and significant (p < 0.001) decreases in tumor weight, tumor volume, packed cell volume and viable cell count and extended the life span of EAC-bearing mice. Hematological profiles were significantly (p < 0.001) normalized in CETD treated mice as compared to EAC control. CETD treatment significantly (p < 0.001) modulated the aforementioned hepatic antioxidative parameters as compared to EAC control. The present study demonstrated that CETD possessed promising antiproliferative efficacy against EAC in mice, plausibly mediated by alleviation of oxidative stress by multiple mechanisms.

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    MeSH

    Animals
    Antineoplastic Agents
    Antioxidants
    Ascites
    Carcinoma, Ehrlich Tumor
    Catalase
    Cell Proliferation
    Glutathione
    Lipid Peroxidation
    Male
    Malondialdehyde
    Mice
    Oxidative Stress
    Phytotherapy
    Plant Extracts
    Plant Roots
    Superoxide Dismutase
    Trichosanthes
    Tumor Burden

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    22545421

    Citation

    TY - JOUR T1 - The triterpenoid fraction from Trichosanthes dioica root exhibits antiproliferative activity against Ehrlich ascites carcinoma in albino mice: involvement of possible antioxidant role. AU - Bhattacharya,Sanjib, AU - Haldar,Pallab Kanti, PY - 2012/5/2/entrez PY - 2012/5/2/pubmed PY - 2012/5/18/medline SP - 281 EP - 90 JF - Journal of experimental therapeutics & oncology JO - J. Exp. Ther. Oncol. VL - 9 IS - 4 N2 - The present study assessed the triterpenoid fraction from T dioica root (CETD) for antiproliferative effect and antioxidant influence against Ehrlich ascites carcinoma (EAC) in Swiss albino mice. Twenty-four hours after intraperitoneal inoculation of tumor (EAC) cells in mice, CETD was administered at 2 and 4 mg/ kg body weight daily for 9 consecutive days. On the 10th day, half of the mice were sacrificed for estimation of tumor proliferation, haematological, and hepatic antioxidative parameters viz. lipid peroxidation, reduced glutathione (GSH), glutathione-S-transferase (GST), superoxide dismutase(SOD)and catalase (CAT); the rest were kept alive for assessment of survival parameters. The antiproliferative effect of CETD was assessed by evaluating tumor weight, tumor volume, packed cell volume, viable and non-viable tumor cell counts, mean survival time and percentage increase in life span of EAC-bearing mice. CETD exhibited dose dependent and significant (p < 0.001) decreases in tumor weight, tumor volume, packed cell volume and viable cell count and extended the life span of EAC-bearing mice. Hematological profiles were significantly (p < 0.001) normalized in CETD treated mice as compared to EAC control. CETD treatment significantly (p < 0.001) modulated the aforementioned hepatic antioxidative parameters as compared to EAC control. The present study demonstrated that CETD possessed promising antiproliferative efficacy against EAC in mice, plausibly mediated by alleviation of oxidative stress by multiple mechanisms. SN - 1359-4117 UR - https://www.unboundmedicine.com/medline/citation/22545421/The_triterpenoid_fraction_from_Trichosanthes_dioica_root_exhibits_antiproliferative_activity_against_Ehrlich_ascites_carcinoma_in_albino_mice:_involvement_of_possible_antioxidant_role_ L2 - http://openurl.ebscohost.com/linksvc/linking.aspx?genre=article&amp;sid=PubMed&amp;issn=1359-4117&amp;title=J Exp Ther Oncol&amp;volume=9&amp;issue=4&amp;spage=281&amp;atitle=The triterpenoid fraction from Trichosanthes dioica root exhibits antiproliferative activity against Ehrlich ascites carcinoma in albino mice: involvement of possible antioxidant role.&amp;aulast=Bhattacharya&amp;date=2012 ER -