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microRNA-206 promotes skeletal muscle regeneration and delays progression of Duchenne muscular dystrophy in mice.
J Clin Invest. 2012 Jun; 122(6):2054-65.JCI

Abstract

Skeletal muscle injury activates adult myogenic stem cells, known as satellite cells, to initiate proliferation and differentiation to regenerate new muscle fibers. The skeletal muscle-specific microRNA miR-206 is upregulated in satellite cells following muscle injury, but its role in muscle regeneration has not been defined. Here, we show that miR-206 promotes skeletal muscle regeneration in response to injury. Genetic deletion of miR-206 in mice substantially delayed regeneration induced by cardiotoxin injury. Furthermore, loss of miR-206 accelerated and exacerbated the dystrophic phenotype in a mouse model of Duchenne muscular dystrophy. We found that miR-206 acts to promote satellite cell differentiation and fusion into muscle fibers through suppressing a collection of negative regulators of myogenesis. Our findings reveal an essential role for miR-206 in satellite cell differentiation during skeletal muscle regeneration and indicate that miR-206 slows progression of Duchenne muscular dystrophy.

Authors+Show Affiliations

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9148, USA. Ning.Liu@utsouthwestern.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22546853

Citation

Liu, Ning, et al. "MicroRNA-206 Promotes Skeletal Muscle Regeneration and Delays Progression of Duchenne Muscular Dystrophy in Mice." The Journal of Clinical Investigation, vol. 122, no. 6, 2012, pp. 2054-65.
Liu N, Williams AH, Maxeiner JM, et al. MicroRNA-206 promotes skeletal muscle regeneration and delays progression of Duchenne muscular dystrophy in mice. J Clin Invest. 2012;122(6):2054-65.
Liu, N., Williams, A. H., Maxeiner, J. M., Bezprozvannaya, S., Shelton, J. M., Richardson, J. A., Bassel-Duby, R., & Olson, E. N. (2012). MicroRNA-206 promotes skeletal muscle regeneration and delays progression of Duchenne muscular dystrophy in mice. The Journal of Clinical Investigation, 122(6), 2054-65. https://doi.org/10.1172/JCI62656
Liu N, et al. MicroRNA-206 Promotes Skeletal Muscle Regeneration and Delays Progression of Duchenne Muscular Dystrophy in Mice. J Clin Invest. 2012;122(6):2054-65. PubMed PMID: 22546853.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - microRNA-206 promotes skeletal muscle regeneration and delays progression of Duchenne muscular dystrophy in mice. AU - Liu,Ning, AU - Williams,Andrew H, AU - Maxeiner,Johanna M, AU - Bezprozvannaya,Svetlana, AU - Shelton,John M, AU - Richardson,James A, AU - Bassel-Duby,Rhonda, AU - Olson,Eric N, Y1 - 2012/05/01/ PY - 2011/12/30/received PY - 2012/03/14/accepted PY - 2012/5/2/entrez PY - 2012/5/2/pubmed PY - 2012/8/21/medline SP - 2054 EP - 65 JF - The Journal of clinical investigation JO - J Clin Invest VL - 122 IS - 6 N2 - Skeletal muscle injury activates adult myogenic stem cells, known as satellite cells, to initiate proliferation and differentiation to regenerate new muscle fibers. The skeletal muscle-specific microRNA miR-206 is upregulated in satellite cells following muscle injury, but its role in muscle regeneration has not been defined. Here, we show that miR-206 promotes skeletal muscle regeneration in response to injury. Genetic deletion of miR-206 in mice substantially delayed regeneration induced by cardiotoxin injury. Furthermore, loss of miR-206 accelerated and exacerbated the dystrophic phenotype in a mouse model of Duchenne muscular dystrophy. We found that miR-206 acts to promote satellite cell differentiation and fusion into muscle fibers through suppressing a collection of negative regulators of myogenesis. Our findings reveal an essential role for miR-206 in satellite cell differentiation during skeletal muscle regeneration and indicate that miR-206 slows progression of Duchenne muscular dystrophy. SN - 1558-8238 UR - https://www.unboundmedicine.com/medline/citation/22546853/microRNA_206_promotes_skeletal_muscle_regeneration_and_delays_progression_of_Duchenne_muscular_dystrophy_in_mice_ L2 - https://doi.org/10.1172/JCI62656 DB - PRIME DP - Unbound Medicine ER -