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Effect of restraint stress on nociceptive responses in rats: role of the histaminergic system.
Niger J Physiol Sci. 2011 Dec 20; 26(2):139-41.NJ

Abstract

Stress induced analgesia (SIA) is well known, but the reverse phenomenon, hyperalgesia is poorly documented. This study investigated the role of the histaminergic system in restraint stress hyperalgesia in rats, using thermal stimulation method (hot plate and tail flick tests). Paw licking and tail withdrawal latencies were taken before and after restraint for about one hour. Significant decreases (p<0.05) were obtained in these latencies after the restraint in both tests. Administration of H1 and H2 receptor blockers, chlorpheniramine and cimetidine respectively 30 mins before the restraint still resulted in significant reductions (p<0.05) in these latencies, connoting the persistence of hyperalgesia, showing that histamine H1 and H2 receptors did not participate in the mechanism of restraint stress hyperalgesia. We therefore suggest a histaminergic independent mechanism for restraint stress induced hyperalgesia.

Authors+Show Affiliations

. gibironk@yahoo.com.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22547182

Citation

Ibironke, G F., and N E. Mordi. "Effect of Restraint Stress On Nociceptive Responses in Rats: Role of the Histaminergic System." Nigerian Journal of Physiological Sciences : Official Publication of the Physiological Society of Nigeria, vol. 26, no. 2, 2011, pp. 139-41.
Ibironke GF, Mordi NE. Effect of restraint stress on nociceptive responses in rats: role of the histaminergic system. Niger J Physiol Sci. 2011;26(2):139-41.
Ibironke, G. F., & Mordi, N. E. (2011). Effect of restraint stress on nociceptive responses in rats: role of the histaminergic system. Nigerian Journal of Physiological Sciences : Official Publication of the Physiological Society of Nigeria, 26(2), 139-41.
Ibironke GF, Mordi NE. Effect of Restraint Stress On Nociceptive Responses in Rats: Role of the Histaminergic System. Niger J Physiol Sci. 2011 Dec 20;26(2):139-41. PubMed PMID: 22547182.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of restraint stress on nociceptive responses in rats: role of the histaminergic system. AU - Ibironke,G F, AU - Mordi,N E, Y1 - 2011/12/20/ PY - 2011/04/02/received PY - 2011/04/02/accepted PY - 2012/5/2/entrez PY - 2011/1/1/pubmed PY - 2014/8/13/medline SP - 139 EP - 41 JF - Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria JO - Niger J Physiol Sci VL - 26 IS - 2 N2 - Stress induced analgesia (SIA) is well known, but the reverse phenomenon, hyperalgesia is poorly documented. This study investigated the role of the histaminergic system in restraint stress hyperalgesia in rats, using thermal stimulation method (hot plate and tail flick tests). Paw licking and tail withdrawal latencies were taken before and after restraint for about one hour. Significant decreases (p<0.05) were obtained in these latencies after the restraint in both tests. Administration of H1 and H2 receptor blockers, chlorpheniramine and cimetidine respectively 30 mins before the restraint still resulted in significant reductions (p<0.05) in these latencies, connoting the persistence of hyperalgesia, showing that histamine H1 and H2 receptors did not participate in the mechanism of restraint stress hyperalgesia. We therefore suggest a histaminergic independent mechanism for restraint stress induced hyperalgesia. SN - 0794-859X UR - https://www.unboundmedicine.com/medline/citation/22547182/Effect_of_restraint_stress_on_nociceptive_responses_in_rats:_role_of_the_histaminergic_system_ L2 - https://medlineplus.gov/stress.html DB - PRIME DP - Unbound Medicine ER -