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Evaluation of serum adipokines in peripheral arterial occlusive disease.
Mediators Inflamm. 2012; 2012:257808.MI

Abstract

AIM

Out study aimed to assess the serum levels of adipokines in patients with peripheral arterial occlusive disease (PAOD) caused by atherosclerosis.

METHODS

Serum samples were obtained from 221 patients. One hundred and forty patients, (26 females and 114 males) met the inclusion criteria and were assigned into the case group. Eighty one patients (17 females and 64 males), were included in the control group. Circulating plasma levels of adiponectin, leptin, resistin, and TNF-α were measured using the enzyme-linked immunosorbent assay (ELISA) method.

RESULTS

Significant lower levels of adiponectin were present (P = 0.0061) in PAOD patients (2380.23 ± 1634.42 pg/mL) compared to the control group (3065.06 ± 1901.2 pg/mL). The mean value of leptin (2844.42 ± 3301.08 pg/mL) and resistin (2047.81±3301.08 pg/mL) patients included in the PAOD group was higher, as compared to the control group. Statistically significant difference was found between the two groups for leptin (P = 0.0332) and for resistin (P = 0.0352). No statistically significant difference for TNF-α was found between the two groups (P > 0.05).

CONCLUSION

The markers of inflammation secreted by the adipose tissue (adiponectin, leptin, resistin) showed significant differences in patients from the case group (with PAOD) compared to the control group.

Authors+Show Affiliations

Surgical Clinic II, Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, No. 4-6 Clinicilor Street, 400006 Cluj-Napoca, Romania.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22547903

Citation

Gherman, Claudia D., and Aurel I. Mironiuc. "Evaluation of Serum Adipokines in Peripheral Arterial Occlusive Disease." Mediators of Inflammation, vol. 2012, 2012, p. 257808.
Gherman CD, Mironiuc AI. Evaluation of serum adipokines in peripheral arterial occlusive disease. Mediators Inflamm. 2012;2012:257808.
Gherman, C. D., & Mironiuc, A. I. (2012). Evaluation of serum adipokines in peripheral arterial occlusive disease. Mediators of Inflammation, 2012, 257808. https://doi.org/10.1155/2012/257808
Gherman CD, Mironiuc AI. Evaluation of Serum Adipokines in Peripheral Arterial Occlusive Disease. Mediators Inflamm. 2012;2012:257808. PubMed PMID: 22547903.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of serum adipokines in peripheral arterial occlusive disease. AU - Gherman,Claudia D, AU - Mironiuc,Aurel I, Y1 - 2012/04/04/ PY - 2011/10/12/received PY - 2012/01/06/revised PY - 2012/01/20/accepted PY - 2012/5/2/entrez PY - 2012/5/2/pubmed PY - 2012/9/21/medline SP - 257808 EP - 257808 JF - Mediators of inflammation JO - Mediators Inflamm. VL - 2012 N2 - AIM: Out study aimed to assess the serum levels of adipokines in patients with peripheral arterial occlusive disease (PAOD) caused by atherosclerosis. METHODS: Serum samples were obtained from 221 patients. One hundred and forty patients, (26 females and 114 males) met the inclusion criteria and were assigned into the case group. Eighty one patients (17 females and 64 males), were included in the control group. Circulating plasma levels of adiponectin, leptin, resistin, and TNF-α were measured using the enzyme-linked immunosorbent assay (ELISA) method. RESULTS: Significant lower levels of adiponectin were present (P = 0.0061) in PAOD patients (2380.23 ± 1634.42 pg/mL) compared to the control group (3065.06 ± 1901.2 pg/mL). The mean value of leptin (2844.42 ± 3301.08 pg/mL) and resistin (2047.81±3301.08 pg/mL) patients included in the PAOD group was higher, as compared to the control group. Statistically significant difference was found between the two groups for leptin (P = 0.0332) and for resistin (P = 0.0352). No statistically significant difference for TNF-α was found between the two groups (P > 0.05). CONCLUSION: The markers of inflammation secreted by the adipose tissue (adiponectin, leptin, resistin) showed significant differences in patients from the case group (with PAOD) compared to the control group. SN - 1466-1861 UR - https://www.unboundmedicine.com/medline/citation/22547903/Evaluation_of_serum_adipokines_in_peripheral_arterial_occlusive_disease_ L2 - https://doi.org/10.1155/2012/257808 DB - PRIME DP - Unbound Medicine ER -