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Regulation of the glucocorticoid response to stress-related disorders by the Hsp90-binding immunophilin FKBP51.
J Neurochem. 2012 Jul; 122(1):4-18.JN

Abstract

Immunophilin is the collective name given to a family of proteins that bind immunosuppressive drugs: Some immunophilins are Hsp90-binding cochaperones that affect steroid receptor function. Mood and anxiety disorders are stress-related diseases characterized by an impaired function of the mineralocorticoid and glucocorticoid receptors, two of the major regulatory elements of the hypothalamus-pituitary-adrenocortical axis. Genetic variations of the FK506-binding protein of 51-kDa, FKBP51, one of the immunophilins bound to those steroid receptor complexes, were associated with the effectiveness of treatments against depression and with a major risk-factor for the development of post-traumatic stress disorders. Interestingly, immunophilins show polymorphisms and some polymorphic isoforms of FKBP51 correlate with a greater impairment of steroid receptor functions. In this review, we discuss different aspects of the role of FKBP51 in such steroid receptor function and the impact of genetic variants of the immunophilin on the dysregulation of the stress response.

Authors+Show Affiliations

Instituto de Biología y Medicina Experimental (IBYME-CONICET), Buenos Aires, Argentina. mgali@qb.fcen.uba.arNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

22548329

Citation

Galigniana, Natalia M., et al. "Regulation of the Glucocorticoid Response to Stress-related Disorders By the Hsp90-binding Immunophilin FKBP51." Journal of Neurochemistry, vol. 122, no. 1, 2012, pp. 4-18.
Galigniana NM, Ballmer LT, Toneatto J, et al. Regulation of the glucocorticoid response to stress-related disorders by the Hsp90-binding immunophilin FKBP51. J Neurochem. 2012;122(1):4-18.
Galigniana, N. M., Ballmer, L. T., Toneatto, J., Erlejman, A. G., Lagadari, M., & Galigniana, M. D. (2012). Regulation of the glucocorticoid response to stress-related disorders by the Hsp90-binding immunophilin FKBP51. Journal of Neurochemistry, 122(1), 4-18. https://doi.org/10.1111/j.1471-4159.2012.07775.x
Galigniana NM, et al. Regulation of the Glucocorticoid Response to Stress-related Disorders By the Hsp90-binding Immunophilin FKBP51. J Neurochem. 2012;122(1):4-18. PubMed PMID: 22548329.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Regulation of the glucocorticoid response to stress-related disorders by the Hsp90-binding immunophilin FKBP51. AU - Galigniana,Natalia M, AU - Ballmer,Luzia T, AU - Toneatto,Judith, AU - Erlejman,Alejandra G, AU - Lagadari,Mariana, AU - Galigniana,Mario D, Y1 - 2012/05/21/ PY - 2012/5/3/entrez PY - 2012/5/3/pubmed PY - 2012/8/28/medline SP - 4 EP - 18 JF - Journal of neurochemistry JO - J Neurochem VL - 122 IS - 1 N2 - Immunophilin is the collective name given to a family of proteins that bind immunosuppressive drugs: Some immunophilins are Hsp90-binding cochaperones that affect steroid receptor function. Mood and anxiety disorders are stress-related diseases characterized by an impaired function of the mineralocorticoid and glucocorticoid receptors, two of the major regulatory elements of the hypothalamus-pituitary-adrenocortical axis. Genetic variations of the FK506-binding protein of 51-kDa, FKBP51, one of the immunophilins bound to those steroid receptor complexes, were associated with the effectiveness of treatments against depression and with a major risk-factor for the development of post-traumatic stress disorders. Interestingly, immunophilins show polymorphisms and some polymorphic isoforms of FKBP51 correlate with a greater impairment of steroid receptor functions. In this review, we discuss different aspects of the role of FKBP51 in such steroid receptor function and the impact of genetic variants of the immunophilin on the dysregulation of the stress response. SN - 1471-4159 UR - https://www.unboundmedicine.com/medline/citation/22548329/Regulation_of_the_glucocorticoid_response_to_stress_related_disorders_by_the_Hsp90_binding_immunophilin_FKBP51_ L2 - https://doi.org/10.1111/j.1471-4159.2012.07775.x DB - PRIME DP - Unbound Medicine ER -