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[Osteocyte and DMP1].
Clin Calcium. 2012 May; 22(5):713-20.CC

Abstract

Dentin matrix protein (DMP1) is a non-collagenous bone matrix protein produced specifically by osteocytes. Because of its highly acidic nature, DMP1 can participate in bone matrix mineralization through Ca(2 +) binding capacity. Inactivating mutations in DMP1 have recently been shown to cause autosomal recessive hypophosphatemic rickets (ARHR) . In a murine model of ARHR, DMP1-null mice had increased fibroblast growth factor23 (FGF23) expression in osteocytes, indicating that DMP1 participates in the systemic phosphate regulation by restraining osteocytic FGF23 production. In addition, the DMP1 promoter has been used frequently as an osteocyte-specific promoter. However, DMP1 is not expressed in all osteocytes. DMP1 expression is seen in osteoblastic-, osteoid-, young osteocytes of the superficial bone layer, but is reduced remarkably in old osteocytes distributed over the bone inside. This pattern of DMP1 expression may influence the interpretation of DMP1 function and the studies that use the DMP1 promoter.

Authors+Show Affiliations

Department of Oral Pathology, Osaka University Graduate School of Dentistry, Japan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

jpn

PubMed ID

22549196

Citation

Toyosawa, Satoru, et al. "[Osteocyte and DMP1]." Clinical Calcium, vol. 22, no. 5, 2012, pp. 713-20.
Toyosawa S, Oya K, Sato S, et al. [Osteocyte and DMP1]. Clin Calcium. 2012;22(5):713-20.
Toyosawa, S., Oya, K., Sato, S., & Ishida, K. (2012). [Osteocyte and DMP1]. Clinical Calcium, 22(5), 713-20. https://doi.org/CliCa1205713720
Toyosawa S, et al. [Osteocyte and DMP1]. Clin Calcium. 2012;22(5):713-20. PubMed PMID: 22549196.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Osteocyte and DMP1]. AU - Toyosawa,Satoru, AU - Oya,Kaori, AU - Sato,Sunao, AU - Ishida,Ken, PY - 2012/5/3/entrez PY - 2012/5/3/pubmed PY - 2012/8/31/medline SP - 713 EP - 20 JF - Clinical calcium JO - Clin Calcium VL - 22 IS - 5 N2 - Dentin matrix protein (DMP1) is a non-collagenous bone matrix protein produced specifically by osteocytes. Because of its highly acidic nature, DMP1 can participate in bone matrix mineralization through Ca(2 +) binding capacity. Inactivating mutations in DMP1 have recently been shown to cause autosomal recessive hypophosphatemic rickets (ARHR) . In a murine model of ARHR, DMP1-null mice had increased fibroblast growth factor23 (FGF23) expression in osteocytes, indicating that DMP1 participates in the systemic phosphate regulation by restraining osteocytic FGF23 production. In addition, the DMP1 promoter has been used frequently as an osteocyte-specific promoter. However, DMP1 is not expressed in all osteocytes. DMP1 expression is seen in osteoblastic-, osteoid-, young osteocytes of the superficial bone layer, but is reduced remarkably in old osteocytes distributed over the bone inside. This pattern of DMP1 expression may influence the interpretation of DMP1 function and the studies that use the DMP1 promoter. SN - 0917-5857 UR - https://www.unboundmedicine.com/medline/citation/22549196/[Osteocyte_and_DMP1]_ DB - PRIME DP - Unbound Medicine ER -