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Habitual flavonoid intakes are positively associated with bone mineral density in women.
J Bone Miner Res. 2012 Sep; 27(9):1872-8.JB

Abstract

Dietary flavonoids exert bone-protective effects in animal models, but there is limited information on the effect of different flavonoid subclasses on bone health in humans. The aim of this observational study was to examine the association between habitual intake of flavonoid subclasses with bone mineral density (BMD) in a cohort of female twins. A total of 3160 women from the TwinsUK adult twin registry participated in the study. Habitual intakes of flavonoids and subclasses (flavanones, anthocyanins, flavan-3-ols, polymers, flavonols, and flavones) were calculated from semiquantitative food frequency questionnaires using an updated and extended U.S. Department of Agriculture (USDA) database. Bone density was measured using dual-energy X-ray absorptiometry. In multivariate analyses, total flavonoid intake was positively associated with higher BMD at the spine but not at the hip. For the subclasses, the magnitude of effect was greatest for anthocyanins, with a 0.034 g/cm(2) (3.4%) and 0.029 g/cm(2) (3.1%) higher BMD at the spine and hip, respectively, for women in the highest intake quintile compared to those in the lowest. Participants in the top quintile of flavone intake had a higher BMD at both sites; 0.021 g/cm(2) (spine) and 0.026 g/cm(2) (hip). At the spine, a greater intake of flavonols and polymers was associated with a higher BMD (0.021 and 0.024 g/cm(2) , respectively), whereas a higher flavanone intake was positively associated with hip BMD (0.008 g/cm(2)). In conclusion, total flavonoid intake was positively associated with BMD, with effects observed for anthocyanins and flavones at both the hip and spine, supporting a role for flavonoids present in plant-based foods on bone health. .

Authors+Show Affiliations

Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Twin Study

Language

eng

PubMed ID

22549983

Citation

Welch, Ailsa, et al. "Habitual Flavonoid Intakes Are Positively Associated With Bone Mineral Density in Women." Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, vol. 27, no. 9, 2012, pp. 1872-8.
Welch A, MacGregor A, Jennings A, et al. Habitual flavonoid intakes are positively associated with bone mineral density in women. J Bone Miner Res. 2012;27(9):1872-8.
Welch, A., MacGregor, A., Jennings, A., Fairweather-Tait, S., Spector, T., & Cassidy, A. (2012). Habitual flavonoid intakes are positively associated with bone mineral density in women. Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, 27(9), 1872-8. https://doi.org/10.1002/jbmr.1649
Welch A, et al. Habitual Flavonoid Intakes Are Positively Associated With Bone Mineral Density in Women. J Bone Miner Res. 2012;27(9):1872-8. PubMed PMID: 22549983.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Habitual flavonoid intakes are positively associated with bone mineral density in women. AU - Welch,Ailsa, AU - MacGregor,Alex, AU - Jennings,Amy, AU - Fairweather-Tait,Sue, AU - Spector,Tim, AU - Cassidy,Aedín, PY - 2012/5/3/entrez PY - 2012/5/3/pubmed PY - 2012/12/27/medline SP - 1872 EP - 8 JF - Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research JO - J Bone Miner Res VL - 27 IS - 9 N2 - Dietary flavonoids exert bone-protective effects in animal models, but there is limited information on the effect of different flavonoid subclasses on bone health in humans. The aim of this observational study was to examine the association between habitual intake of flavonoid subclasses with bone mineral density (BMD) in a cohort of female twins. A total of 3160 women from the TwinsUK adult twin registry participated in the study. Habitual intakes of flavonoids and subclasses (flavanones, anthocyanins, flavan-3-ols, polymers, flavonols, and flavones) were calculated from semiquantitative food frequency questionnaires using an updated and extended U.S. Department of Agriculture (USDA) database. Bone density was measured using dual-energy X-ray absorptiometry. In multivariate analyses, total flavonoid intake was positively associated with higher BMD at the spine but not at the hip. For the subclasses, the magnitude of effect was greatest for anthocyanins, with a 0.034 g/cm(2) (3.4%) and 0.029 g/cm(2) (3.1%) higher BMD at the spine and hip, respectively, for women in the highest intake quintile compared to those in the lowest. Participants in the top quintile of flavone intake had a higher BMD at both sites; 0.021 g/cm(2) (spine) and 0.026 g/cm(2) (hip). At the spine, a greater intake of flavonols and polymers was associated with a higher BMD (0.021 and 0.024 g/cm(2) , respectively), whereas a higher flavanone intake was positively associated with hip BMD (0.008 g/cm(2)). In conclusion, total flavonoid intake was positively associated with BMD, with effects observed for anthocyanins and flavones at both the hip and spine, supporting a role for flavonoids present in plant-based foods on bone health. . SN - 1523-4681 UR - https://www.unboundmedicine.com/medline/citation/22549983/Habitual_flavonoid_intakes_are_positively_associated_with_bone_mineral_density_in_women_ DB - PRIME DP - Unbound Medicine ER -