Kozlovskiĭ, I I., et al. "[The Role of Opioid System in Peculiarities of Anti-anxiety Effect of Peptide Anxiolytic Selank]." Eksperimental'naia I Klinicheskaia Farmakologiia, vol. 75, no. 2, 2012, pp. 10-3.
Kozlovskiĭ II, Andreeva LA, Kozlovskaia MM, et al. [The role of opioid system in peculiarities of anti-anxiety effect of peptide anxiolytic selank]. Eksp Klin Farmakol. 2012;75(2):10-3.
Kozlovskiĭ, I. I., Andreeva, L. A., Kozlovskaia, M. M., Nadorova, A. V., & Kolik, L. G. (2012). [The role of opioid system in peculiarities of anti-anxiety effect of peptide anxiolytic selank]. Eksperimental'naia I Klinicheskaia Farmakologiia, 75(2), 10-3.
Kozlovskiĭ II, et al. [The Role of Opioid System in Peculiarities of Anti-anxiety Effect of Peptide Anxiolytic Selank]. Eksp Klin Farmakol. 2012;75(2):10-3. PubMed PMID: 22550852.
TY - JOUR
T1 - [The role of opioid system in peculiarities of anti-anxiety effect of peptide anxiolytic selank].
AU - Kozlovskiĭ,I I,
AU - Andreeva,L A,
AU - Kozlovskaia,M M,
AU - Nadorova,A V,
AU - Kolik,L G,
PY - 2012/5/4/entrez
PY - 2012/5/4/pubmed
PY - 2012/5/30/medline
SP - 10
EP - 3
JF - Eksperimental'naia i klinicheskaia farmakologiia
JO - Eksp Klin Farmakol
VL - 75
IS - 2
N2 - Peculiarities of the anxiolytic effects of selank (heptapeptide analog of taftsin) under reduced activity of opioid system upon acute administration of naloxone have been studied in BALB/C and C57BL/6 inbred mice with high and low levels of anxiety, with passive and active emotional stress reaction phenotypes in the open field (OF) test. Selank (0.25 mg/kg, i.p.) per se exhibited anxiolytic effect in BALB/C mice by increasing the general locomotor activity, with no effects on the behavior of C57BL/6 mice in the OF test. Naloxone (1.0 mg/kg, i.p.) per se evoked swift runaway in OF peripheral areas in BALB/C mice while "freezing" the reaction in C57BL/6 mice with active response to stress under the same conditions. Pretreatment with naloxone attenuated the sensitivity to selank in BALB/C mice whereas the response to anxiolytic effects of peptide was increased in C57BL/6 mice. The data obtained reveal a new target for selank in CNS and indicate significance of the activity of enkephalin-opioid system in individual sensitivity to selank.
SN - 0869-2092
UR - https://www.unboundmedicine.com/medline/citation/22550852/[The_role_of_opioid_system_in_peculiarities_of_anti_anxiety_effect_of_peptide_anxiolytic_selank]_
L2 - https://medlineplus.gov/anxiety.html
DB - PRIME
DP - Unbound Medicine