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[The role of opioid system in peculiarities of anti-anxiety effect of peptide anxiolytic selank].
Eksp Klin Farmakol. 2012; 75(2):10-3.EK

Abstract

Peculiarities of the anxiolytic effects of selank (heptapeptide analog of taftsin) under reduced activity of opioid system upon acute administration of naloxone have been studied in BALB/C and C57BL/6 inbred mice with high and low levels of anxiety, with passive and active emotional stress reaction phenotypes in the open field (OF) test. Selank (0.25 mg/kg, i.p.) per se exhibited anxiolytic effect in BALB/C mice by increasing the general locomotor activity, with no effects on the behavior of C57BL/6 mice in the OF test. Naloxone (1.0 mg/kg, i.p.) per se evoked swift runaway in OF peripheral areas in BALB/C mice while "freezing" the reaction in C57BL/6 mice with active response to stress under the same conditions. Pretreatment with naloxone attenuated the sensitivity to selank in BALB/C mice whereas the response to anxiolytic effects of peptide was increased in C57BL/6 mice. The data obtained reveal a new target for selank in CNS and indicate significance of the activity of enkephalin-opioid system in individual sensitivity to selank.

Authors

Kozlovskiĭ II
No affiliation info available
Andreeva LA
No affiliation info available
Kozlovskaia MM
No affiliation info available
Nadorova AV
No affiliation info available
Kolik LG
No affiliation info available

MeSH

Analgesics, OpioidAnimalsAnti-Anxiety AgentsAnxietyCentral Nervous SystemEscape ReactionFreezing Reaction, CatalepticInjections, IntraperitonealMaleMiceMice, Inbred BALB CMice, Inbred C57BLNaloxoneNarcotic AntagonistsOligopeptidesReceptors, OpioidSpecies SpecificityStress, Psychological

Pub Type(s)

Journal Article

Language

rus

PubMed ID

22550852

Citation

Kozlovskiĭ, I I., et al. "[The Role of Opioid System in Peculiarities of Anti-anxiety Effect of Peptide Anxiolytic Selank]." Eksperimental'naia I Klinicheskaia Farmakologiia, vol. 75, no. 2, 2012, pp. 10-3.
Kozlovskiĭ II, Andreeva LA, Kozlovskaia MM, et al. [The role of opioid system in peculiarities of anti-anxiety effect of peptide anxiolytic selank]. Eksp Klin Farmakol. 2012;75(2):10-3.
Kozlovskiĭ, I. I., Andreeva, L. A., Kozlovskaia, M. M., Nadorova, A. V., & Kolik, L. G. (2012). [The role of opioid system in peculiarities of anti-anxiety effect of peptide anxiolytic selank]. Eksperimental'naia I Klinicheskaia Farmakologiia, 75(2), 10-3.
Kozlovskiĭ II, et al. [The Role of Opioid System in Peculiarities of Anti-anxiety Effect of Peptide Anxiolytic Selank]. Eksp Klin Farmakol. 2012;75(2):10-3. PubMed PMID: 22550852.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The role of opioid system in peculiarities of anti-anxiety effect of peptide anxiolytic selank]. AU - Kozlovskiĭ,I I, AU - Andreeva,L A, AU - Kozlovskaia,M M, AU - Nadorova,A V, AU - Kolik,L G, PY - 2012/5/4/entrez PY - 2012/5/4/pubmed PY - 2012/5/30/medline SP - 10 EP - 3 JF - Eksperimental'naia i klinicheskaia farmakologiia JO - Eksp Klin Farmakol VL - 75 IS - 2 N2 - Peculiarities of the anxiolytic effects of selank (heptapeptide analog of taftsin) under reduced activity of opioid system upon acute administration of naloxone have been studied in BALB/C and C57BL/6 inbred mice with high and low levels of anxiety, with passive and active emotional stress reaction phenotypes in the open field (OF) test. Selank (0.25 mg/kg, i.p.) per se exhibited anxiolytic effect in BALB/C mice by increasing the general locomotor activity, with no effects on the behavior of C57BL/6 mice in the OF test. Naloxone (1.0 mg/kg, i.p.) per se evoked swift runaway in OF peripheral areas in BALB/C mice while "freezing" the reaction in C57BL/6 mice with active response to stress under the same conditions. Pretreatment with naloxone attenuated the sensitivity to selank in BALB/C mice whereas the response to anxiolytic effects of peptide was increased in C57BL/6 mice. The data obtained reveal a new target for selank in CNS and indicate significance of the activity of enkephalin-opioid system in individual sensitivity to selank. SN - 0869-2092 UR - https://www.unboundmedicine.com/medline/citation/22550852/[The_role_of_opioid_system_in_peculiarities_of_anti_anxiety_effect_of_peptide_anxiolytic_selank]_ L2 - https://medlineplus.gov/anxiety.html DB - PRIME DP - Unbound Medicine ER -