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Pharmacotherapy to control behavioral symptoms in children with autism.
Expert Opin Pharmacother. 2012 Aug; 13(11):1615-29.EO

Abstract

INTRODUCTION

Autistic disorder, Asperger's disorder, and pervasive developmental disorder not otherwise specified (PDD-NOS) are pervasive developmental disorders (PDDs) frequently associated with behavioral symptoms that may require pharmacotherapy to manage.

AREAS COVERED

Behavioral symptoms in children with autism include interfering repetitive behaviors, irritability, and hyperactivity and inattention, among others. The psychotropic medications examined in this review include: serotonin reuptake inhibitors, typical and atypical antipsychotics, medications used to treat attention-deficit/hyperactivity disorder, naltrexone, buspirone, divalproex sodium, lamotrigine, levetiracetam, memantine, mirtazapine, riluzole, pioglitazone, and topiramate.

EXPERT OPINION

For the treatment of interfering repetitive behaviors, serotonin reuptake inhibitors demonstrate less efficacy and are more poorly tolerated in children with autism compared to adults. Antipsychotics are the most efficacious drugs for the treatment of irritability in children with autism and other PDDs. For the treatment of hyperactivity and inattention, psychostimulants demonstrate some benefit. However, they are overall less efficacious and cause more side effects in children with PDDs compared to typically developing children with attention-deficit/hyperactivity disorder. Results from double-blind, placebo-controlled trials of these agents and others for the treatment of the behavioral symptom domains described above will be discussed in this review.

Authors+Show Affiliations

Indiana University School of Medicine and Christian Sarkine Autism Treatment Center, Riley Hospital for Children, Department of Psychiatry, IN, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

22550944

Citation

Doyle, Carolyn A., and Christopher J. McDougle. "Pharmacotherapy to Control Behavioral Symptoms in Children With Autism." Expert Opinion On Pharmacotherapy, vol. 13, no. 11, 2012, pp. 1615-29.
Doyle CA, McDougle CJ. Pharmacotherapy to control behavioral symptoms in children with autism. Expert Opin Pharmacother. 2012;13(11):1615-29.
Doyle, C. A., & McDougle, C. J. (2012). Pharmacotherapy to control behavioral symptoms in children with autism. Expert Opinion On Pharmacotherapy, 13(11), 1615-29. https://doi.org/10.1517/14656566.2012.674110
Doyle CA, McDougle CJ. Pharmacotherapy to Control Behavioral Symptoms in Children With Autism. Expert Opin Pharmacother. 2012;13(11):1615-29. PubMed PMID: 22550944.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pharmacotherapy to control behavioral symptoms in children with autism. AU - Doyle,Carolyn A, AU - McDougle,Christopher J, Y1 - 2012/05/03/ PY - 2012/5/4/entrez PY - 2012/5/4/pubmed PY - 2012/11/8/medline SP - 1615 EP - 29 JF - Expert opinion on pharmacotherapy JO - Expert Opin Pharmacother VL - 13 IS - 11 N2 - INTRODUCTION: Autistic disorder, Asperger's disorder, and pervasive developmental disorder not otherwise specified (PDD-NOS) are pervasive developmental disorders (PDDs) frequently associated with behavioral symptoms that may require pharmacotherapy to manage. AREAS COVERED: Behavioral symptoms in children with autism include interfering repetitive behaviors, irritability, and hyperactivity and inattention, among others. The psychotropic medications examined in this review include: serotonin reuptake inhibitors, typical and atypical antipsychotics, medications used to treat attention-deficit/hyperactivity disorder, naltrexone, buspirone, divalproex sodium, lamotrigine, levetiracetam, memantine, mirtazapine, riluzole, pioglitazone, and topiramate. EXPERT OPINION: For the treatment of interfering repetitive behaviors, serotonin reuptake inhibitors demonstrate less efficacy and are more poorly tolerated in children with autism compared to adults. Antipsychotics are the most efficacious drugs for the treatment of irritability in children with autism and other PDDs. For the treatment of hyperactivity and inattention, psychostimulants demonstrate some benefit. However, they are overall less efficacious and cause more side effects in children with PDDs compared to typically developing children with attention-deficit/hyperactivity disorder. Results from double-blind, placebo-controlled trials of these agents and others for the treatment of the behavioral symptom domains described above will be discussed in this review. SN - 1744-7666 UR - https://www.unboundmedicine.com/medline/citation/22550944/Pharmacotherapy_to_control_behavioral_symptoms_in_children_with_autism_ L2 - https://www.tandfonline.com/doi/full/10.1517/14656566.2012.674110 DB - PRIME DP - Unbound Medicine ER -