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Effectiveness of 1 dose of 2009 influenza A (H1N1) vaccine at preventing hospitalization with pandemic H1N1 influenza in children aged 7 months-9 years.
J Infect Dis. 2012 Jul 01; 206(1):49-55.JI

Abstract

The availability of a well-established immunization registry to provide vaccination information, a school-located vaccination campaign followed by continued 2009 influenza A (H1N1) (pH1N1) activity, and a requirement to report hospitalized influenza cases provided an opportunity to estimate vaccine effectiveness (VE) of an initial dose of pH1N1 monovalent vaccine in children aged 7 months-9 years. Seventy-eight case children and 729 date-of-birth- and zipcode-matched controls were studied. The VE of a single vaccine dose in preventing pH1N1 hospitalization ≥ 14 days after vaccination was 82% (95% confidence interval [CI], 0%-100%; P = .04) in children aged 3-9 years but was zero (-3%; 95% CI, <0%-75%) in children aged 7-35 months. These findings are consistent with those from prelicensure immunogenicity studies and have implications for interpretation of immunogenicity studies and setting priorities for vaccination of young children in future pandemics. Immunization registries can provide a simple, rapid assessment of VE to evaluate and inform vaccination policy.

Authors+Show Affiliations

New York City Department of Health and Mental Hygiene, New York 11101-4132, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

22551808

Citation

Hadler, James L., et al. "Effectiveness of 1 Dose of 2009 Influenza a (H1N1) Vaccine at Preventing Hospitalization With Pandemic H1N1 Influenza in Children Aged 7 Months-9 Years." The Journal of Infectious Diseases, vol. 206, no. 1, 2012, pp. 49-55.
Hadler JL, Baker TN, Papadouka V, et al. Effectiveness of 1 dose of 2009 influenza A (H1N1) vaccine at preventing hospitalization with pandemic H1N1 influenza in children aged 7 months-9 years. J Infect Dis. 2012;206(1):49-55.
Hadler, J. L., Baker, T. N., Papadouka, V., France, A. M., Zimmerman, C., Livingston, K. A., & Zucker, J. R. (2012). Effectiveness of 1 dose of 2009 influenza A (H1N1) vaccine at preventing hospitalization with pandemic H1N1 influenza in children aged 7 months-9 years. The Journal of Infectious Diseases, 206(1), 49-55. https://doi.org/10.1093/infdis/jis306
Hadler JL, et al. Effectiveness of 1 Dose of 2009 Influenza a (H1N1) Vaccine at Preventing Hospitalization With Pandemic H1N1 Influenza in Children Aged 7 Months-9 Years. J Infect Dis. 2012 Jul 1;206(1):49-55. PubMed PMID: 22551808.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effectiveness of 1 dose of 2009 influenza A (H1N1) vaccine at preventing hospitalization with pandemic H1N1 influenza in children aged 7 months-9 years. AU - Hadler,James L, AU - Baker,Tai N, AU - Papadouka,Vikki, AU - France,Anne Marie, AU - Zimmerman,Christopher, AU - Livingston,Kara A, AU - Zucker,Jane R, Y1 - 2012/05/02/ PY - 2012/5/4/entrez PY - 2012/5/4/pubmed PY - 2012/10/2/medline SP - 49 EP - 55 JF - The Journal of infectious diseases JO - J Infect Dis VL - 206 IS - 1 N2 - The availability of a well-established immunization registry to provide vaccination information, a school-located vaccination campaign followed by continued 2009 influenza A (H1N1) (pH1N1) activity, and a requirement to report hospitalized influenza cases provided an opportunity to estimate vaccine effectiveness (VE) of an initial dose of pH1N1 monovalent vaccine in children aged 7 months-9 years. Seventy-eight case children and 729 date-of-birth- and zipcode-matched controls were studied. The VE of a single vaccine dose in preventing pH1N1 hospitalization ≥ 14 days after vaccination was 82% (95% confidence interval [CI], 0%-100%; P = .04) in children aged 3-9 years but was zero (-3%; 95% CI, <0%-75%) in children aged 7-35 months. These findings are consistent with those from prelicensure immunogenicity studies and have implications for interpretation of immunogenicity studies and setting priorities for vaccination of young children in future pandemics. Immunization registries can provide a simple, rapid assessment of VE to evaluate and inform vaccination policy. SN - 1537-6613 UR - https://www.unboundmedicine.com/medline/citation/22551808/Effectiveness_of_1_dose_of_2009_influenza_A__H1N1__vaccine_at_preventing_hospitalization_with_pandemic_H1N1_influenza_in_children_aged_7_months_9_years_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1093/infdis/jis306 DB - PRIME DP - Unbound Medicine ER -