Tags

Type your tag names separated by a space and hit enter

Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis.
Am J Clin Nutr 2012; 95(6):1357-64AJ

Abstract

BACKGROUND

Currently, there is a lack of clarity in the literature as to whether there is a definitive difference between the effects of vitamins D2 and D3 in the raising of serum 25-hydroxyvitamin D [25(OH)D].

OBJECTIVE

The objective of this article was to report a systematic review and meta-analysis of randomized controlled trials (RCTs) that have directly compared the effects of vitamin D2 and vitamin D3 on serum 25(OH)D concentrations in humans.

DESIGN

The ISI Web of Knowledge (January 1966 to July 2011) database was searched electronically for all relevant studies in adults that directly compared vitamin D3 with vitamin D2. The Cochrane Clinical Trials Registry, International Standard Randomized Controlled Trials Number register, and clinicaltrials.gov were also searched for any unpublished trials.

RESULTS

A meta-analysis of RCTs indicated that supplementation with vitamin D3 had a significant and positive effect in the raising of serum 25(OH)D concentrations compared with the effect of vitamin D2 (P = 0.001). When the frequency of dosage administration was compared, there was a significant response for vitamin D3 when given as a bolus dose (P = 0.0002) compared with administration of vitamin D2, but the effect was lost with daily supplementation.

CONCLUSIONS

This meta-analysis indicates that vitamin D3 is more efficacious at raising serum 25(OH)D concentrations than is vitamin D2, and thus vitamin D3) could potentially become the preferred choice for supplementation. However, additional research is required to examine the metabolic pathways involved in oral and intramuscular administration of vitamin D and the effects across age, sex, and ethnicity, which this review was unable to verify.

Authors+Show Affiliations

Department of Nutrition and Metabolism, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK. laura.tripkovic@surrey.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review
Systematic Review

Language

eng

PubMed ID

22552031

Citation

Tripkovic, Laura, et al. "Comparison of Vitamin D2 and Vitamin D3 Supplementation in Raising Serum 25-hydroxyvitamin D Status: a Systematic Review and Meta-analysis." The American Journal of Clinical Nutrition, vol. 95, no. 6, 2012, pp. 1357-64.
Tripkovic L, Lambert H, Hart K, et al. Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis. Am J Clin Nutr. 2012;95(6):1357-64.
Tripkovic, L., Lambert, H., Hart, K., Smith, C. P., Bucca, G., Penson, S., ... Lanham-New, S. (2012). Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis. The American Journal of Clinical Nutrition, 95(6), pp. 1357-64. doi:10.3945/ajcn.111.031070.
Tripkovic L, et al. Comparison of Vitamin D2 and Vitamin D3 Supplementation in Raising Serum 25-hydroxyvitamin D Status: a Systematic Review and Meta-analysis. Am J Clin Nutr. 2012;95(6):1357-64. PubMed PMID: 22552031.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis. AU - Tripkovic,Laura, AU - Lambert,Helen, AU - Hart,Kathryn, AU - Smith,Colin P, AU - Bucca,Giselda, AU - Penson,Simon, AU - Chope,Gemma, AU - Hyppönen,Elina, AU - Berry,Jacqueline, AU - Vieth,Reinhold, AU - Lanham-New,Susan, Y1 - 2012/05/02/ PY - 2012/5/4/entrez PY - 2012/5/4/pubmed PY - 2012/7/28/medline SP - 1357 EP - 64 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 95 IS - 6 N2 - BACKGROUND: Currently, there is a lack of clarity in the literature as to whether there is a definitive difference between the effects of vitamins D2 and D3 in the raising of serum 25-hydroxyvitamin D [25(OH)D]. OBJECTIVE: The objective of this article was to report a systematic review and meta-analysis of randomized controlled trials (RCTs) that have directly compared the effects of vitamin D2 and vitamin D3 on serum 25(OH)D concentrations in humans. DESIGN: The ISI Web of Knowledge (January 1966 to July 2011) database was searched electronically for all relevant studies in adults that directly compared vitamin D3 with vitamin D2. The Cochrane Clinical Trials Registry, International Standard Randomized Controlled Trials Number register, and clinicaltrials.gov were also searched for any unpublished trials. RESULTS: A meta-analysis of RCTs indicated that supplementation with vitamin D3 had a significant and positive effect in the raising of serum 25(OH)D concentrations compared with the effect of vitamin D2 (P = 0.001). When the frequency of dosage administration was compared, there was a significant response for vitamin D3 when given as a bolus dose (P = 0.0002) compared with administration of vitamin D2, but the effect was lost with daily supplementation. CONCLUSIONS: This meta-analysis indicates that vitamin D3 is more efficacious at raising serum 25(OH)D concentrations than is vitamin D2, and thus vitamin D3) could potentially become the preferred choice for supplementation. However, additional research is required to examine the metabolic pathways involved in oral and intramuscular administration of vitamin D and the effects across age, sex, and ethnicity, which this review was unable to verify. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/22552031/Comparison_of_vitamin_D2_and_vitamin_D3_supplementation_in_raising_serum_25_hydroxyvitamin_D_status:_a_systematic_review_and_meta_analysis_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.111.031070 DB - PRIME DP - Unbound Medicine ER -