Tags

Type your tag names separated by a space and hit enter

Dietary acid load and risk of hypertension: the Rotterdam Study.
Am J Clin Nutr. 2012 Jun; 95(6):1438-44.AJ

Abstract

BACKGROUND

Mild metabolic acidosis, which can be caused by diet, may result in elevated blood pressure (BP).

DESIGN

The analyses included 2241 participants aged ≥55 y who were free of hypertension at baseline (1990-1993) and who had complete dietary and BP data. Dietary data were obtained from a 170-item food-frequency questionnaire. We used 2 measures to characterize dietary acid load: (1) potential renal acid load (PRAL) by using an algorithm including protein, phosphorus, potassium, calcium, and magnesium, and (2) estimated net endogenous acid production (NEAP) based on protein and potassium. HRs for 6-y incidence of hypertension were obtained in tertiles of PRAL and NEAP with adjustment for age, sex, BMI, smoking, education, and intakes of alcohol, fiber, and total energy.

RESULTS

We identified 1113 incident cases of hypertension during 8707 person-years of follow-up. The median dietary acid load ranged from -14.6 to 19.9 mEq/d across categories of PRAL. Hypertension risk was not significantly associated with dietary acid load. The multivariate HRs (95% CIs) in consecutive tertiles of PRAL were 1.00 (reference), 1.01 (0.87, 1.17), and 1.02 (0.88, 1.18) (P trend = 0.83). The median dietary acid loads were 30.4, 36.7, and 43.7 mEq/d, respectively, in consecutive tertiles of NEAP. Corresponding HRs for NEAP were 1.00 (reference), 0.92 (0.80, 1.07), and 0.94 (0.81, 1.10) (P-trend = 0.46).

CONCLUSION

The findings from this prospective cohort study provided no evidence of an association between dietary acid load and risk of hypertension in older adults.

Authors+Show Affiliations

Top Institute Food and Nutrition, Wageningen, Netherlands. marielle.engberink@wur.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22552032

Citation

Engberink, Marielle F., et al. "Dietary Acid Load and Risk of Hypertension: the Rotterdam Study." The American Journal of Clinical Nutrition, vol. 95, no. 6, 2012, pp. 1438-44.
Engberink MF, Bakker SJ, Brink EJ, et al. Dietary acid load and risk of hypertension: the Rotterdam Study. Am J Clin Nutr. 2012;95(6):1438-44.
Engberink, M. F., Bakker, S. J., Brink, E. J., van Baak, M. A., van Rooij, F. J., Hofman, A., Witteman, J. C., & Geleijnse, J. M. (2012). Dietary acid load and risk of hypertension: the Rotterdam Study. The American Journal of Clinical Nutrition, 95(6), 1438-44. https://doi.org/10.3945/ajcn.111.022343
Engberink MF, et al. Dietary Acid Load and Risk of Hypertension: the Rotterdam Study. Am J Clin Nutr. 2012;95(6):1438-44. PubMed PMID: 22552032.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary acid load and risk of hypertension: the Rotterdam Study. AU - Engberink,Marielle F, AU - Bakker,Stephan J L, AU - Brink,Elizabeth J, AU - van Baak,Marleen A, AU - van Rooij,Frank J A, AU - Hofman,Albert, AU - Witteman,Jacqueline C M, AU - Geleijnse,Johanna M, Y1 - 2012/05/02/ PY - 2012/5/4/entrez PY - 2012/5/4/pubmed PY - 2012/7/28/medline SP - 1438 EP - 44 JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 95 IS - 6 N2 - BACKGROUND: Mild metabolic acidosis, which can be caused by diet, may result in elevated blood pressure (BP). DESIGN: The analyses included 2241 participants aged ≥55 y who were free of hypertension at baseline (1990-1993) and who had complete dietary and BP data. Dietary data were obtained from a 170-item food-frequency questionnaire. We used 2 measures to characterize dietary acid load: (1) potential renal acid load (PRAL) by using an algorithm including protein, phosphorus, potassium, calcium, and magnesium, and (2) estimated net endogenous acid production (NEAP) based on protein and potassium. HRs for 6-y incidence of hypertension were obtained in tertiles of PRAL and NEAP with adjustment for age, sex, BMI, smoking, education, and intakes of alcohol, fiber, and total energy. RESULTS: We identified 1113 incident cases of hypertension during 8707 person-years of follow-up. The median dietary acid load ranged from -14.6 to 19.9 mEq/d across categories of PRAL. Hypertension risk was not significantly associated with dietary acid load. The multivariate HRs (95% CIs) in consecutive tertiles of PRAL were 1.00 (reference), 1.01 (0.87, 1.17), and 1.02 (0.88, 1.18) (P trend = 0.83). The median dietary acid loads were 30.4, 36.7, and 43.7 mEq/d, respectively, in consecutive tertiles of NEAP. Corresponding HRs for NEAP were 1.00 (reference), 0.92 (0.80, 1.07), and 0.94 (0.81, 1.10) (P-trend = 0.46). CONCLUSION: The findings from this prospective cohort study provided no evidence of an association between dietary acid load and risk of hypertension in older adults. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/22552032/Dietary_acid_load_and_risk_of_hypertension:_the_Rotterdam_Study_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.111.022343 DB - PRIME DP - Unbound Medicine ER -