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Relative effectiveness of oral 25-hydroxyvitamin D3 and vitamin D3 in raising wintertime serum 25-hydroxyvitamin D in older adults.
Am J Clin Nutr. 2012 Jun; 95(6):1350-6.AJ

Abstract

BACKGROUND

The relative potency of 25-hydroxyvitamin D3 to vitamin D3 needs to be better defined so that food-composition tables can better reflect the true vitamin D nutritive value of certain foods.

OBJECTIVE

We performed a randomized, controlled intervention study in apparently healthy, free-living adults to investigate whether the intake of 25-hydroxyvitamin D3 is 5 times more potent in raising serum 25-hydroxyvitamin D [25(OH)D] during winter compared with an equivalent amount of vitamin D3.

DESIGN

A randomized, placebo-controlled, double-blind intervention study was conducted in adults aged ≥50 y (n = 56) who consumed a placebo, 20 μg vitamin D3, or 7 or 20 μg 25-hydroxyvitamin D3 daily throughout 10 wk of winter. Serum 25(OH)D was measured by using an enzyme-linked immunoassay, and serum albumin-corrected calcium (S-Ca) was assessed colorimetrically at the baseline, midpoint, and endpoint of the study.

RESULTS

The mean (±SD) increases (per microgram of vitamin D compound) in serum 25(OH)D concentrations over baseline after 10 wk of supplementation were 0.96 ± 0.62, 4.02 ± 1.27, and 4.77 ± 1.04 nmol · L(-1) · μg intake(-1) for the 20-μg vitamin D3/d and 7- and 20-μg 25-hydroxyvitamin D3/d groups, respectively. A comparison of the 7- and 20-μg 25-hydroxyvitamin D3/d groups with the 20-μg vitamin D3/d group yielded conversion factors of 4.2 and 5, respectively. There was no effect of treatment on S-Ca concentrations and no incidence of hypercalcemia (S-Ca >2.6 nmol/L).

CONCLUSIONS

Each microgram of orally consumed 25-hydroxyvitamin D3 was about 5 times more effective in raising serum 25(OH)D in older adults in winter than an equivalent amount of vitamin D3. This conversion factor could be used in food-compositional tables for relevant foods. This study was registered at clinicaltrials.gov as NCT01398202.

Authors+Show Affiliations

School of Food and Nutritional Sciences, Department of Medicine, University College Cork, Cork, Ireland. k.cashman@ucc.ieNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22552038

Citation

Cashman, Kevin D., et al. "Relative Effectiveness of Oral 25-hydroxyvitamin D3 and Vitamin D3 in Raising Wintertime Serum 25-hydroxyvitamin D in Older Adults." The American Journal of Clinical Nutrition, vol. 95, no. 6, 2012, pp. 1350-6.
Cashman KD, Seamans KM, Lucey AJ, et al. Relative effectiveness of oral 25-hydroxyvitamin D3 and vitamin D3 in raising wintertime serum 25-hydroxyvitamin D in older adults. Am J Clin Nutr. 2012;95(6):1350-6.
Cashman, K. D., Seamans, K. M., Lucey, A. J., Stöcklin, E., Weber, P., Kiely, M., & Hill, T. R. (2012). Relative effectiveness of oral 25-hydroxyvitamin D3 and vitamin D3 in raising wintertime serum 25-hydroxyvitamin D in older adults. The American Journal of Clinical Nutrition, 95(6), 1350-6. https://doi.org/10.3945/ajcn.111.031427
Cashman KD, et al. Relative Effectiveness of Oral 25-hydroxyvitamin D3 and Vitamin D3 in Raising Wintertime Serum 25-hydroxyvitamin D in Older Adults. Am J Clin Nutr. 2012;95(6):1350-6. PubMed PMID: 22552038.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relative effectiveness of oral 25-hydroxyvitamin D3 and vitamin D3 in raising wintertime serum 25-hydroxyvitamin D in older adults. AU - Cashman,Kevin D, AU - Seamans,Kelly M, AU - Lucey,Alice J, AU - Stöcklin,Elisabeth, AU - Weber,Peter, AU - Kiely,Mairead, AU - Hill,Tom R, Y1 - 2012/05/02/ PY - 2012/5/4/entrez PY - 2012/5/4/pubmed PY - 2012/7/28/medline SP - 1350 EP - 6 JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 95 IS - 6 N2 - BACKGROUND: The relative potency of 25-hydroxyvitamin D3 to vitamin D3 needs to be better defined so that food-composition tables can better reflect the true vitamin D nutritive value of certain foods. OBJECTIVE: We performed a randomized, controlled intervention study in apparently healthy, free-living adults to investigate whether the intake of 25-hydroxyvitamin D3 is 5 times more potent in raising serum 25-hydroxyvitamin D [25(OH)D] during winter compared with an equivalent amount of vitamin D3. DESIGN: A randomized, placebo-controlled, double-blind intervention study was conducted in adults aged ≥50 y (n = 56) who consumed a placebo, 20 μg vitamin D3, or 7 or 20 μg 25-hydroxyvitamin D3 daily throughout 10 wk of winter. Serum 25(OH)D was measured by using an enzyme-linked immunoassay, and serum albumin-corrected calcium (S-Ca) was assessed colorimetrically at the baseline, midpoint, and endpoint of the study. RESULTS: The mean (±SD) increases (per microgram of vitamin D compound) in serum 25(OH)D concentrations over baseline after 10 wk of supplementation were 0.96 ± 0.62, 4.02 ± 1.27, and 4.77 ± 1.04 nmol · L(-1) · μg intake(-1) for the 20-μg vitamin D3/d and 7- and 20-μg 25-hydroxyvitamin D3/d groups, respectively. A comparison of the 7- and 20-μg 25-hydroxyvitamin D3/d groups with the 20-μg vitamin D3/d group yielded conversion factors of 4.2 and 5, respectively. There was no effect of treatment on S-Ca concentrations and no incidence of hypercalcemia (S-Ca >2.6 nmol/L). CONCLUSIONS: Each microgram of orally consumed 25-hydroxyvitamin D3 was about 5 times more effective in raising serum 25(OH)D in older adults in winter than an equivalent amount of vitamin D3. This conversion factor could be used in food-compositional tables for relevant foods. This study was registered at clinicaltrials.gov as NCT01398202. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/22552038/Relative_effectiveness_of_oral_25_hydroxyvitamin_D3_and_vitamin_D3_in_raising_wintertime_serum_25_hydroxyvitamin_D_in_older_adults_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.111.031427 DB - PRIME DP - Unbound Medicine ER -