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Development of novel ibuprofen-loaded solid dispersion with enhanced bioavailability using cycloamylose.
Arch Pharm Res. 2012 Mar; 35(4):683-9.AP

Abstract

To develop a novel ibuprofen-loaded solid dispersion with enhanced bioavailability using cycloamylose, it was prepared using spray-drying techniques with cycloamylose at a weight ratio of 1:1. The effect of cycloamylose on aqueous solubility of ibuprofen was investigated. The physicochemical properties of solid dispersions were investigated using scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and X-ray diffraction. The dissolution and bioavailability in rats were evaluated compared with ibuprofen powder. This ibuprofen-loaded solid dispersion improved about 14-fold drug solubility. Ibuprofen was present in an unchanged crystalline state, and cycloamylose played the simple role of a solubilizing agent in this solid dispersion. Moreover, the dispersion gave 2-fold higher AUC (area under the drug concentration-time curve) value compared with a ibuprofen powder, indicating that it improved the oral bioavailability of ibuprofen in rats. Thus, the solid dispersion may be useful to deliver ibuprofen with enhanced bioavailability without crystalline change.

Authors+Show Affiliations

Department of Food Engineering, Dankook University, Cheonan, 330-714, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22553061

Citation

Baek, Hyung Hee, et al. "Development of Novel Ibuprofen-loaded Solid Dispersion With Enhanced Bioavailability Using Cycloamylose." Archives of Pharmacal Research, vol. 35, no. 4, 2012, pp. 683-9.
Baek HH, Kim DH, Kwon SY, et al. Development of novel ibuprofen-loaded solid dispersion with enhanced bioavailability using cycloamylose. Arch Pharm Res. 2012;35(4):683-9.
Baek, H. H., Kim, D. H., Kwon, S. Y., Rho, S. J., Kim, D. W., Choi, H. G., Kim, Y. R., & Yong, C. S. (2012). Development of novel ibuprofen-loaded solid dispersion with enhanced bioavailability using cycloamylose. Archives of Pharmacal Research, 35(4), 683-9. https://doi.org/10.1007/s12272-012-0412-4
Baek HH, et al. Development of Novel Ibuprofen-loaded Solid Dispersion With Enhanced Bioavailability Using Cycloamylose. Arch Pharm Res. 2012;35(4):683-9. PubMed PMID: 22553061.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Development of novel ibuprofen-loaded solid dispersion with enhanced bioavailability using cycloamylose. AU - Baek,Hyung Hee, AU - Kim,Dae-Hwan, AU - Kwon,So Young, AU - Rho,Shin-Joung, AU - Kim,Dong-Wuk, AU - Choi,Han-Gon, AU - Kim,Yong-Ro, AU - Yong,Chul Soon, Y1 - 2012/05/03/ PY - 2011/07/08/received PY - 2011/09/09/accepted PY - 2011/08/29/revised PY - 2012/5/4/entrez PY - 2012/5/4/pubmed PY - 2012/9/14/medline SP - 683 EP - 9 JF - Archives of pharmacal research JO - Arch Pharm Res VL - 35 IS - 4 N2 - To develop a novel ibuprofen-loaded solid dispersion with enhanced bioavailability using cycloamylose, it was prepared using spray-drying techniques with cycloamylose at a weight ratio of 1:1. The effect of cycloamylose on aqueous solubility of ibuprofen was investigated. The physicochemical properties of solid dispersions were investigated using scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and X-ray diffraction. The dissolution and bioavailability in rats were evaluated compared with ibuprofen powder. This ibuprofen-loaded solid dispersion improved about 14-fold drug solubility. Ibuprofen was present in an unchanged crystalline state, and cycloamylose played the simple role of a solubilizing agent in this solid dispersion. Moreover, the dispersion gave 2-fold higher AUC (area under the drug concentration-time curve) value compared with a ibuprofen powder, indicating that it improved the oral bioavailability of ibuprofen in rats. Thus, the solid dispersion may be useful to deliver ibuprofen with enhanced bioavailability without crystalline change. SN - 0253-6269 UR - https://www.unboundmedicine.com/medline/citation/22553061/Development_of_novel_ibuprofen_loaded_solid_dispersion_with_enhanced_bioavailability_using_cycloamylose_ L2 - https://dx.doi.org/10.1007/s12272-012-0412-4 DB - PRIME DP - Unbound Medicine ER -