Tags

Type your tag names separated by a space and hit enter

Differences in cardiovascular disease risk factors associated with maximum and mean carotid intima-media thickness among hemodialysis patients.
Iran J Kidney Dis 2012; 6(3):203-8IJ

Abstract

INTRODUCTION

Carotid intima-media thickness (CIMT) could be used as a surrogate marker of atherosclerosis in hemodialysis patients. Since different mechanisms are involved in the atheroma formation and arterial wall thickness, we assessed the relationship between the maximum and the mean CIMT with different cardiovascular risk factors in dialysis patients.

MATERIALS AND METHODS

The mean and the maximum CIMT were measured using a B-mode ultrasonography in 75 hemodialysis patients, and the correlation between CIMT and cardiovascular risk factors were assessed.

RESULTS

The mean and maximum CIMT measurements were 0.5 mm (range, 0.2 mm to 1 mm) and 3.4 mm (1.4 mm to 5.6 mm), respectively. Among all the studied variables, age (P = .04, r = 0.238), HS-CRP (P = .01, r = 0.284), mean arterial blood pressure (P = .003, r = 0.343), and DM (P = .02) had significant correlations with the mean CIMT, while only age (P = .02, r = 0.473) and serum creatinine levels (P = .02, r = -0.493) were significantly associated with the maximum CIMT. A positive nonsignificant correlation was observed between the mean and maximum CIMT values (P = .08, R2 linear = 0.214).

CONCLUSIONS

These findings suggest that in dialysis patients, effects of cardiovascular risk factors on the mean and maximum CIMT might be different. Further studies are recommended to evaluate the prediction impact of each risk factor in end-stage renal disease patients compared with otherwise healthy individuals.

Authors+Show Affiliations

Shahid Beheshti University of Medical Sciences,Tehran, Iran.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22555485

Citation

Nassiri, Amir Ahmad, et al. "Differences in Cardiovascular Disease Risk Factors Associated With Maximum and Mean Carotid Intima-media Thickness Among Hemodialysis Patients." Iranian Journal of Kidney Diseases, vol. 6, no. 3, 2012, pp. 203-8.
Nassiri AA, Hakemi MS, Asadzadeh R, et al. Differences in cardiovascular disease risk factors associated with maximum and mean carotid intima-media thickness among hemodialysis patients. Iran J Kidney Dis. 2012;6(3):203-8.
Nassiri, A. A., Hakemi, M. S., Asadzadeh, R., Faizei, A. M., Alatab, S., Miri, R., & Yaseri, M. (2012). Differences in cardiovascular disease risk factors associated with maximum and mean carotid intima-media thickness among hemodialysis patients. Iranian Journal of Kidney Diseases, 6(3), pp. 203-8.
Nassiri AA, et al. Differences in Cardiovascular Disease Risk Factors Associated With Maximum and Mean Carotid Intima-media Thickness Among Hemodialysis Patients. Iran J Kidney Dis. 2012;6(3):203-8. PubMed PMID: 22555485.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differences in cardiovascular disease risk factors associated with maximum and mean carotid intima-media thickness among hemodialysis patients. AU - Nassiri,Amir Ahmad, AU - Hakemi,Monir Sadat, AU - Asadzadeh,Reza, AU - Faizei,Ali Mohammad, AU - Alatab,Sudabeh, AU - Miri,Reza, AU - Yaseri,Mehdi, PY - 2011/10/31/received PY - 2012/01/29/accepted PY - 2012/5/5/entrez PY - 2012/5/5/pubmed PY - 2012/7/17/medline SP - 203 EP - 8 JF - Iranian journal of kidney diseases JO - Iran J Kidney Dis VL - 6 IS - 3 N2 - INTRODUCTION: Carotid intima-media thickness (CIMT) could be used as a surrogate marker of atherosclerosis in hemodialysis patients. Since different mechanisms are involved in the atheroma formation and arterial wall thickness, we assessed the relationship between the maximum and the mean CIMT with different cardiovascular risk factors in dialysis patients. MATERIALS AND METHODS: The mean and the maximum CIMT were measured using a B-mode ultrasonography in 75 hemodialysis patients, and the correlation between CIMT and cardiovascular risk factors were assessed. RESULTS: The mean and maximum CIMT measurements were 0.5 mm (range, 0.2 mm to 1 mm) and 3.4 mm (1.4 mm to 5.6 mm), respectively. Among all the studied variables, age (P = .04, r = 0.238), HS-CRP (P = .01, r = 0.284), mean arterial blood pressure (P = .003, r = 0.343), and DM (P = .02) had significant correlations with the mean CIMT, while only age (P = .02, r = 0.473) and serum creatinine levels (P = .02, r = -0.493) were significantly associated with the maximum CIMT. A positive nonsignificant correlation was observed between the mean and maximum CIMT values (P = .08, R2 linear = 0.214). CONCLUSIONS: These findings suggest that in dialysis patients, effects of cardiovascular risk factors on the mean and maximum CIMT might be different. Further studies are recommended to evaluate the prediction impact of each risk factor in end-stage renal disease patients compared with otherwise healthy individuals. SN - 1735-8604 UR - https://www.unboundmedicine.com/medline/citation/22555485/Differences_in_cardiovascular_disease_risk_factors_associated_with_maximum_and_mean_carotid_intima_media_thickness_among_hemodialysis_patients_ L2 - http://www.ijkd.org/index.php/ijkd/article/view/664/408 DB - PRIME DP - Unbound Medicine ER -