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Guillain-Barré syndrome after H1N1 vaccination in the United States: a report using the CDC/FDA Vaccine Adverse Event Reporting System (2009).
Neuroepidemiology. 2012; 38(4):227-32.N

Abstract

BACKGROUND

Although the Guillain-Barré syndrome (GBS) can be associated with the seasonal influenza vaccine, there is no definite evidence that GBS is associated with H1N1 influenza vaccination. The objective of this report is to study the occurrence and characteristics of GBS after H1N1 vaccine administration in the United States in 2009.

METHODS

Data were acquired from the Vaccine Adverse Event Reporting System and supplemented by additional information obtained from the Center for Biologics Evaluation and Research, under the Federal Freedom of Information Act.

RESULTS

A total of 62 individuals (mean age 46.51 ± 22.41 years), 33 of whom were men, developed GBS associated with the H1N1 influenza vaccination in 2009. Sixty GBS cases were reported within 6 weeks after vaccination, with 31 cases (50.0%) reported in the first 2 weeks. The estimated rate of occurrence of GBS was 6.2 cases per 10 million vaccinations, which is comparable to the rate of GBS in the general population.

CONCLUSION

The higher rate of GBS reports in the first 6 weeks after H1N1 vaccination suggests that some GBS cases may be triggered by H1N1 vaccination. This warrants early recognition, treatment, and active surveillance in the postvaccination setting.

Authors+Show Affiliations

Department of Neurology, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA. souayani@umdnj.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22555646

Citation

Souayah, Nizar, et al. "Guillain-Barré Syndrome After H1N1 Vaccination in the United States: a Report Using the CDC/FDA Vaccine Adverse Event Reporting System (2009)." Neuroepidemiology, vol. 38, no. 4, 2012, pp. 227-32.
Souayah N, Yacoub HA, Khan HM, et al. Guillain-Barré syndrome after H1N1 vaccination in the United States: a report using the CDC/FDA Vaccine Adverse Event Reporting System (2009). Neuroepidemiology. 2012;38(4):227-32.
Souayah, N., Yacoub, H. A., Khan, H. M., Michas-Martin, P. A., Menkes, D. L., Maybodi, L., & Qureshi, A. I. (2012). Guillain-Barré syndrome after H1N1 vaccination in the United States: a report using the CDC/FDA Vaccine Adverse Event Reporting System (2009). Neuroepidemiology, 38(4), 227-32. https://doi.org/10.1159/000336113
Souayah N, et al. Guillain-Barré Syndrome After H1N1 Vaccination in the United States: a Report Using the CDC/FDA Vaccine Adverse Event Reporting System (2009). Neuroepidemiology. 2012;38(4):227-32. PubMed PMID: 22555646.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Guillain-Barré syndrome after H1N1 vaccination in the United States: a report using the CDC/FDA Vaccine Adverse Event Reporting System (2009). AU - Souayah,Nizar, AU - Yacoub,Hussam A, AU - Khan,Hafiz M R, AU - Michas-Martin,P A, AU - Menkes,Daniel L, AU - Maybodi,Leila, AU - Qureshi,Adnan I, Y1 - 2012/04/27/ PY - 2011/08/17/received PY - 2011/12/24/accepted PY - 2012/5/5/entrez PY - 2012/5/5/pubmed PY - 2012/10/24/medline SP - 227 EP - 32 JF - Neuroepidemiology JO - Neuroepidemiology VL - 38 IS - 4 N2 - BACKGROUND: Although the Guillain-Barré syndrome (GBS) can be associated with the seasonal influenza vaccine, there is no definite evidence that GBS is associated with H1N1 influenza vaccination. The objective of this report is to study the occurrence and characteristics of GBS after H1N1 vaccine administration in the United States in 2009. METHODS: Data were acquired from the Vaccine Adverse Event Reporting System and supplemented by additional information obtained from the Center for Biologics Evaluation and Research, under the Federal Freedom of Information Act. RESULTS: A total of 62 individuals (mean age 46.51 ± 22.41 years), 33 of whom were men, developed GBS associated with the H1N1 influenza vaccination in 2009. Sixty GBS cases were reported within 6 weeks after vaccination, with 31 cases (50.0%) reported in the first 2 weeks. The estimated rate of occurrence of GBS was 6.2 cases per 10 million vaccinations, which is comparable to the rate of GBS in the general population. CONCLUSION: The higher rate of GBS reports in the first 6 weeks after H1N1 vaccination suggests that some GBS cases may be triggered by H1N1 vaccination. This warrants early recognition, treatment, and active surveillance in the postvaccination setting. SN - 1423-0208 UR - https://www.unboundmedicine.com/medline/citation/22555646/Guillain_Barré_syndrome_after_H1N1_vaccination_in_the_United_States:_a_report_using_the_CDC/FDA_Vaccine_Adverse_Event_Reporting_System__2009__ L2 - https://www.karger.com?DOI=10.1159/000336113 DB - PRIME DP - Unbound Medicine ER -