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Incidence of and risk factors for motor neurone disease in UK women: a prospective study.
BMC Neurol 2012; 12:25BN

Abstract

BACKGROUND

Motor neuron disease (MND) is a severe neurodegenerative disease with largely unknown etiology. Most epidemiological studies are hampered by small sample sizes and/or the retrospective collection of information on behavioural and lifestyle factors.

METHODS

1.3 million women from the UK Million Women Study, aged 56 years on average at recruitment, were followed up for incident and/or fatal MND using NHS hospital admission and mortality data. Adjusted relative risks were calculated using Cox regression models.

FINDINGS

During follow-up for an average of 9·2 years, 752 women had a new diagnosis of MND. Age-specific rates increased with age, from 1·9 (95% CI 1·3 - 2·7) to 12·5 (95% CI 10·2 - 15·3) per 100,000 women aged 50-54 to 70-74, respectively, giving a cumulative risk of diagnosis with the disease of 1·74 per 1000 women between the ages of 50 and 75 years. There was no significant variation in risk of MND with region of residence, socio-economic status, education, height, alcohol use, parity, use of oral contraceptives or hormone replacement therapy. Ever-smokers had about a 20% greater risk than never smokers (RR 1·19 95% CI 1·02 to 1·38, p = 0·03). There was a statistically significant reduction in risk of MND with increasing body mass index (p(for trend) = 0·009): obese women (body mass index, 30 kg/m(2) or more) had a 20% lower risk than women of normal body mass index (20 to <25 Kg/m(2))(RR 0·78 95% CI 0·65-0·94; p = 0·03). This effect persisted after exclusion of the first three years of follow-up.

INTERPRETATION

MND incidence in UK women rises rapidly with age, and an estimated 1 in 575 women are likely to be affected between the ages of 50 and 75 years. Smoking slightly increases the risk of MND, and adiposity in middle age is associated with a lower risk of the disease.

Authors+Show Affiliations

Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, UK. pat.doyle@lshtm.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22559076

Citation

Doyle, Pat, et al. "Incidence of and Risk Factors for Motor Neurone Disease in UK Women: a Prospective Study." BMC Neurology, vol. 12, 2012, p. 25.
Doyle P, Brown A, Beral V, et al. Incidence of and risk factors for motor neurone disease in UK women: a prospective study. BMC Neurol. 2012;12:25.
Doyle, P., Brown, A., Beral, V., Reeves, G., & Green, J. (2012). Incidence of and risk factors for motor neurone disease in UK women: a prospective study. BMC Neurology, 12, p. 25. doi:10.1186/1471-2377-12-25.
Doyle P, et al. Incidence of and Risk Factors for Motor Neurone Disease in UK Women: a Prospective Study. BMC Neurol. 2012 May 6;12:25. PubMed PMID: 22559076.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Incidence of and risk factors for motor neurone disease in UK women: a prospective study. AU - Doyle,Pat, AU - Brown,Anna, AU - Beral,Valerie, AU - Reeves,Gillian, AU - Green,Jane, Y1 - 2012/05/06/ PY - 2011/12/15/received PY - 2012/04/17/accepted PY - 2012/5/8/entrez PY - 2012/5/9/pubmed PY - 2013/5/18/medline SP - 25 EP - 25 JF - BMC neurology JO - BMC Neurol VL - 12 N2 - BACKGROUND: Motor neuron disease (MND) is a severe neurodegenerative disease with largely unknown etiology. Most epidemiological studies are hampered by small sample sizes and/or the retrospective collection of information on behavioural and lifestyle factors. METHODS: 1.3 million women from the UK Million Women Study, aged 56 years on average at recruitment, were followed up for incident and/or fatal MND using NHS hospital admission and mortality data. Adjusted relative risks were calculated using Cox regression models. FINDINGS: During follow-up for an average of 9·2 years, 752 women had a new diagnosis of MND. Age-specific rates increased with age, from 1·9 (95% CI 1·3 - 2·7) to 12·5 (95% CI 10·2 - 15·3) per 100,000 women aged 50-54 to 70-74, respectively, giving a cumulative risk of diagnosis with the disease of 1·74 per 1000 women between the ages of 50 and 75 years. There was no significant variation in risk of MND with region of residence, socio-economic status, education, height, alcohol use, parity, use of oral contraceptives or hormone replacement therapy. Ever-smokers had about a 20% greater risk than never smokers (RR 1·19 95% CI 1·02 to 1·38, p = 0·03). There was a statistically significant reduction in risk of MND with increasing body mass index (p(for trend) = 0·009): obese women (body mass index, 30 kg/m(2) or more) had a 20% lower risk than women of normal body mass index (20 to <25 Kg/m(2))(RR 0·78 95% CI 0·65-0·94; p = 0·03). This effect persisted after exclusion of the first three years of follow-up. INTERPRETATION: MND incidence in UK women rises rapidly with age, and an estimated 1 in 575 women are likely to be affected between the ages of 50 and 75 years. Smoking slightly increases the risk of MND, and adiposity in middle age is associated with a lower risk of the disease. SN - 1471-2377 UR - https://www.unboundmedicine.com/medline/citation/22559076/Incidence_of_and_risk_factors_for_motor_neurone_disease_in_UK_women:_a_prospective_study_ L2 - https://bmcneurol.biomedcentral.com/articles/10.1186/1471-2377-12-25 DB - PRIME DP - Unbound Medicine ER -