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Preparation of thiolated polymeric nanocomposite for sensitive electroanalysis of dopamine.
Biosens Bioelectron. 2012 Jun-Jul; 36(1):154-60.BB

Abstract

We report on the thiol-ene chemistry guided preparation of novel thiolated polymeric nanocomposite films of abundant anionic carboxylic groups for electrostatic enrichment and sensitive electroanalysis of cationic dopamine (DA) in neutral solution. Briefly, the thiol-ene nucleophilic reaction of a carboxylated thiol with oxidized polypyrrole (PPy), which was electrosynthesized on an Au electrode in the presence of solution-dispersed acidified multiwalled carbon nanotubes (MWCNTs), produced an a PPy-thiol-MWCNTs/Au electrode, and the PPy can be electrochemically overoxidized (OPPy) to form an OPPy-thiol-MWCNTs/Au electrode. The carboxylic groups of the polymeric nanocomposite film originate from the acidified MWCNTs, PPy-tethered carboxylated thiol, and OPPy. The carboxylated thiols examined are mercaptosuccinic acid (MSA) and thioglycolic acid, with β-mercaptoethanol as a control. Electrochemical quartz crystal microbalance, scanning electron microscopy, Fourier transform infrared spectroscopy and ultraviolet-visible spectroscopy were used for film characterization and process monitoring. Under the optimized condition, the differential pulse voltammetry peak current of DA oxidation at OPPy-MSA-MWCNTs/Au electrode is linear with DA concentration from 1.00×10(-9) to 2.87×10(-6) mol L(-1), with a limit of detection of 0.4 nmol L(-1), good anti-interferent ability and stability.

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Authors+Show Affiliations

Su Z
Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education of China), College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081, China.
Liu Y
No affiliation info available
Xie Q
No affiliation info available
Chen L
No affiliation info available
Zhang Y
No affiliation info available
Meng Y
No affiliation info available
Li Y
No affiliation info available
Fu Y
No affiliation info available
Ma M
No affiliation info available
Yao S
No affiliation info available

MeSH

Biosensing TechniquesDopamineElectrochemistryMicroscopy, Electron, ScanningNanocompositesNanotubes, CarbonOxidation-ReductionPolymersPyrrolesSulfhydryl Compounds

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22560107

Citation

Su, Zhaohong, et al. "Preparation of Thiolated Polymeric Nanocomposite for Sensitive Electroanalysis of Dopamine." Biosensors & Bioelectronics, vol. 36, no. 1, 2012, pp. 154-60.
Su Z, Liu Y, Xie Q, et al. Preparation of thiolated polymeric nanocomposite for sensitive electroanalysis of dopamine. Biosens Bioelectron. 2012;36(1):154-60.
Su, Z., Liu, Y., Xie, Q., Chen, L., Zhang, Y., Meng, Y., Li, Y., Fu, Y., Ma, M., & Yao, S. (2012). Preparation of thiolated polymeric nanocomposite for sensitive electroanalysis of dopamine. Biosensors & Bioelectronics, 36(1), 154-60. https://doi.org/10.1016/j.bios.2012.04.005
Su Z, et al. Preparation of Thiolated Polymeric Nanocomposite for Sensitive Electroanalysis of Dopamine. Biosens Bioelectron. 2012 Jun-Jul;36(1):154-60. PubMed PMID: 22560107.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preparation of thiolated polymeric nanocomposite for sensitive electroanalysis of dopamine. AU - Su,Zhaohong, AU - Liu,Ying, AU - Xie,Qingji, AU - Chen,Li, AU - Zhang,Yi, AU - Meng,Yue, AU - Li,Yan, AU - Fu,Yingchun, AU - Ma,Ming, AU - Yao,Shouzhuo, Y1 - 2012/04/20/ PY - 2012/01/04/received PY - 2012/03/26/revised PY - 2012/04/09/accepted PY - 2012/5/8/entrez PY - 2012/5/9/pubmed PY - 2012/10/26/medline SP - 154 EP - 60 JF - Biosensors & bioelectronics JO - Biosens Bioelectron VL - 36 IS - 1 N2 - We report on the thiol-ene chemistry guided preparation of novel thiolated polymeric nanocomposite films of abundant anionic carboxylic groups for electrostatic enrichment and sensitive electroanalysis of cationic dopamine (DA) in neutral solution. Briefly, the thiol-ene nucleophilic reaction of a carboxylated thiol with oxidized polypyrrole (PPy), which was electrosynthesized on an Au electrode in the presence of solution-dispersed acidified multiwalled carbon nanotubes (MWCNTs), produced an a PPy-thiol-MWCNTs/Au electrode, and the PPy can be electrochemically overoxidized (OPPy) to form an OPPy-thiol-MWCNTs/Au electrode. The carboxylic groups of the polymeric nanocomposite film originate from the acidified MWCNTs, PPy-tethered carboxylated thiol, and OPPy. The carboxylated thiols examined are mercaptosuccinic acid (MSA) and thioglycolic acid, with β-mercaptoethanol as a control. Electrochemical quartz crystal microbalance, scanning electron microscopy, Fourier transform infrared spectroscopy and ultraviolet-visible spectroscopy were used for film characterization and process monitoring. Under the optimized condition, the differential pulse voltammetry peak current of DA oxidation at OPPy-MSA-MWCNTs/Au electrode is linear with DA concentration from 1.00×10(-9) to 2.87×10(-6) mol L(-1), with a limit of detection of 0.4 nmol L(-1), good anti-interferent ability and stability. SN - 1873-4235 UR - https://www.unboundmedicine.com/medline/citation/22560107/Preparation_of_thiolated_polymeric_nanocomposite_for_sensitive_electroanalysis_of_dopamine_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0956-5663(12)00221-7 DB - PRIME DP - Unbound Medicine ER -
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