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Trace elements and antioxidant enzymes associated with oxidative stress in the pre-eclamptic/eclamptic mothers during fetal circulation.
Clin Nutr. 2012 Dec; 31(6):946-50.CN

Abstract

BACKGROUND & AIMS

Pre-eclampsia is associated with oxidative stress in the maternal circulation. The aim of the study was to access the oxidative stress status by quantification of byproducts generated during lipid peroxidation; deficient antioxidant activity and inadequate trace elements during oxidative damage in the umbilical cord blood of pre-eclamptic/eclamptic mothers and its effect on the fetal outcome.

METHODS

In a case control study umbilical cord blood samples were collected during delivery from cases of pre-eclamptic/eclamptic mothers and from normotensive (uncomplicated pregnancy) subjects as controls. Concentrations of malondialdehyde, trace elements (Zn, Cu, Se, Mg) and antioxidant enzymes (SOD, GPx) were determined.

RESULTS

Decreased levels of Zinc (p < 0.001), Copper (p < 0.001), Selenium (p < 0.005), Magnesium (p < 0.05), Superoxide dismutase (p < 0.001), Glutathione Peroxidase (p < 0.001) and elevated levels of malondialdehyde (marker of lipid peroxidation) in the umbilical cord blood of pre-eclamptic and eclamptic pregnancies were observed. Positive correlation between Zn and SOD (Pearson r = 0.581, p < 0.001), Cu and SOD (Pearson r = 0.576, p < 0.001) and Se and GPx (Pearson r = 0.445, p < 0.005) was also observed.

CONCLUSIONS

The reduced levels of trace elements associated with inadequate amount of antioxidant enzymes may be important contributing factor associated with oxidative stress leading to endothelial dysfunction in pre-eclamptic/eclamptic mothers.

Authors+Show Affiliations

Department of Biophysics, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, Uttar Pradesh, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22560448

Citation

Negi, Reena, et al. "Trace Elements and Antioxidant Enzymes Associated With Oxidative Stress in the Pre-eclamptic/eclamptic Mothers During Fetal Circulation." Clinical Nutrition (Edinburgh, Scotland), vol. 31, no. 6, 2012, pp. 946-50.
Negi R, Pande D, Karki K, et al. Trace elements and antioxidant enzymes associated with oxidative stress in the pre-eclamptic/eclamptic mothers during fetal circulation. Clin Nutr. 2012;31(6):946-50.
Negi, R., Pande, D., Karki, K., Kumar, A., Khanna, R. S., & Khanna, H. D. (2012). Trace elements and antioxidant enzymes associated with oxidative stress in the pre-eclamptic/eclamptic mothers during fetal circulation. Clinical Nutrition (Edinburgh, Scotland), 31(6), 946-50. https://doi.org/10.1016/j.clnu.2012.04.005
Negi R, et al. Trace Elements and Antioxidant Enzymes Associated With Oxidative Stress in the Pre-eclamptic/eclamptic Mothers During Fetal Circulation. Clin Nutr. 2012;31(6):946-50. PubMed PMID: 22560448.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Trace elements and antioxidant enzymes associated with oxidative stress in the pre-eclamptic/eclamptic mothers during fetal circulation. AU - Negi,Reena, AU - Pande,Deepti, AU - Karki,Kanchan, AU - Kumar,Ashok, AU - Khanna,Ranjana S, AU - Khanna,Hari D, Y1 - 2012/05/03/ PY - 2011/11/11/received PY - 2012/03/26/revised PY - 2012/04/10/accepted PY - 2012/5/8/entrez PY - 2012/5/9/pubmed PY - 2013/5/10/medline SP - 946 EP - 50 JF - Clinical nutrition (Edinburgh, Scotland) JO - Clin Nutr VL - 31 IS - 6 N2 - BACKGROUND & AIMS: Pre-eclampsia is associated with oxidative stress in the maternal circulation. The aim of the study was to access the oxidative stress status by quantification of byproducts generated during lipid peroxidation; deficient antioxidant activity and inadequate trace elements during oxidative damage in the umbilical cord blood of pre-eclamptic/eclamptic mothers and its effect on the fetal outcome. METHODS: In a case control study umbilical cord blood samples were collected during delivery from cases of pre-eclamptic/eclamptic mothers and from normotensive (uncomplicated pregnancy) subjects as controls. Concentrations of malondialdehyde, trace elements (Zn, Cu, Se, Mg) and antioxidant enzymes (SOD, GPx) were determined. RESULTS: Decreased levels of Zinc (p < 0.001), Copper (p < 0.001), Selenium (p < 0.005), Magnesium (p < 0.05), Superoxide dismutase (p < 0.001), Glutathione Peroxidase (p < 0.001) and elevated levels of malondialdehyde (marker of lipid peroxidation) in the umbilical cord blood of pre-eclamptic and eclamptic pregnancies were observed. Positive correlation between Zn and SOD (Pearson r = 0.581, p < 0.001), Cu and SOD (Pearson r = 0.576, p < 0.001) and Se and GPx (Pearson r = 0.445, p < 0.005) was also observed. CONCLUSIONS: The reduced levels of trace elements associated with inadequate amount of antioxidant enzymes may be important contributing factor associated with oxidative stress leading to endothelial dysfunction in pre-eclamptic/eclamptic mothers. SN - 1532-1983 UR - https://www.unboundmedicine.com/medline/citation/22560448/Trace_elements_and_antioxidant_enzymes_associated_with_oxidative_stress_in_the_pre_eclamptic/eclamptic_mothers_during_fetal_circulation_ DB - PRIME DP - Unbound Medicine ER -