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Brain anomalies in 121 children with non-syndromic single suture craniosynostosis by MR imaging.
Eur J Paediatr Neurol. 2012 Nov; 16(6):671-5.EJ

Abstract

INTRODUCTION

The aim of this study was to evaluate prevalence of intracranial abnormalities in children with non-syndromic single suture craniosynostosis scheduled for cranial vault remodelling surgery using pre-operative magnetic resonance imaging.

PATIENTS AND METHODS

A retrospective analysis of brain magnetic resonance imaging studies of 129 non-syndromic single suture craniosynostosis children undergoing craniofacial surgery between January, 2004-October, 2010 was conducted. Statistical analysis was performed for child, maternal and sibling related predisposing factors for abnormal brain magnetic resonance imaging findings. The mean age of these 121 patients at the time of imaging was 21.6 months. The majority, 78% were males and 74% of the patients were scaphocephalic.

RESULTS

In 18 (15%) patients abnormal brain findings were noted. The most common finding was Chiari 1 malformation in 11 (9%). Chiari 1 malformation comprised over half (61%) of the brain anomalies identified. None of these findings required any additional surgical procedures. None of the statistical analysis reached statistical significance.

CONCLUSIONS

Brain anomalies in connection with non-syndromic single suture craniosynostosis patients seem to be a coincidental event. We did not establish any specific craniosynostosis form to be regularly associated with abnormal brain magnetic resonance imaging findings. The routine use of pre-operative magnetic resonance imaging in non-syndromic single suture craniosynostosis patients seems to be of limited value in the search for associated intracranial malformations necessitating additional interventions.

Authors+Show Affiliations

Cleft Lip and Palate and Craniofacial Centre, Department of Plastic Surgery, Helsinki University Hospital, Helsinki, Finland. ada.hukki@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22560589

Citation

Hukki, A, et al. "Brain Anomalies in 121 Children With Non-syndromic Single Suture Craniosynostosis By MR Imaging." European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society, vol. 16, no. 6, 2012, pp. 671-5.
Hukki A, Koljonen V, Karppinen A, et al. Brain anomalies in 121 children with non-syndromic single suture craniosynostosis by MR imaging. Eur J Paediatr Neurol. 2012;16(6):671-5.
Hukki, A., Koljonen, V., Karppinen, A., Valanne, L., & Leikola, J. (2012). Brain anomalies in 121 children with non-syndromic single suture craniosynostosis by MR imaging. European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society, 16(6), 671-5. https://doi.org/10.1016/j.ejpn.2012.04.003
Hukki A, et al. Brain Anomalies in 121 Children With Non-syndromic Single Suture Craniosynostosis By MR Imaging. Eur J Paediatr Neurol. 2012;16(6):671-5. PubMed PMID: 22560589.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Brain anomalies in 121 children with non-syndromic single suture craniosynostosis by MR imaging. AU - Hukki,A, AU - Koljonen,V, AU - Karppinen,A, AU - Valanne,L, AU - Leikola,J, Y1 - 2012/05/04/ PY - 2012/02/03/received PY - 2012/04/12/revised PY - 2012/04/13/accepted PY - 2012/5/8/entrez PY - 2012/5/9/pubmed PY - 2013/3/8/medline SP - 671 EP - 5 JF - European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society JO - Eur J Paediatr Neurol VL - 16 IS - 6 N2 - INTRODUCTION: The aim of this study was to evaluate prevalence of intracranial abnormalities in children with non-syndromic single suture craniosynostosis scheduled for cranial vault remodelling surgery using pre-operative magnetic resonance imaging. PATIENTS AND METHODS: A retrospective analysis of brain magnetic resonance imaging studies of 129 non-syndromic single suture craniosynostosis children undergoing craniofacial surgery between January, 2004-October, 2010 was conducted. Statistical analysis was performed for child, maternal and sibling related predisposing factors for abnormal brain magnetic resonance imaging findings. The mean age of these 121 patients at the time of imaging was 21.6 months. The majority, 78% were males and 74% of the patients were scaphocephalic. RESULTS: In 18 (15%) patients abnormal brain findings were noted. The most common finding was Chiari 1 malformation in 11 (9%). Chiari 1 malformation comprised over half (61%) of the brain anomalies identified. None of these findings required any additional surgical procedures. None of the statistical analysis reached statistical significance. CONCLUSIONS: Brain anomalies in connection with non-syndromic single suture craniosynostosis patients seem to be a coincidental event. We did not establish any specific craniosynostosis form to be regularly associated with abnormal brain magnetic resonance imaging findings. The routine use of pre-operative magnetic resonance imaging in non-syndromic single suture craniosynostosis patients seems to be of limited value in the search for associated intracranial malformations necessitating additional interventions. SN - 1532-2130 UR - https://www.unboundmedicine.com/medline/citation/22560589/Brain_anomalies_in_121_children_with_non_syndromic_single_suture_craniosynostosis_by_MR_imaging_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1090-3798(12)00093-1 DB - PRIME DP - Unbound Medicine ER -