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Depression is independently associated with 7-year mortality in patients treated with percutaneous coronary intervention: results from the RESEARCH registry.
Int J Cardiol 2013; 167(6):2496-501IJ

Abstract

BACKGROUND

Depression has been associated with poor prognosis in patients with coronary artery disease (CAD), but little is known about the impact of depression on long-term mortality. We examined whether depression was associated with 7-year mortality in patients treated with percutaneous coronary intervention (PCI), after adjusting for socio-demographic and clinical characteristics, anxiety, and the distressed (Type D) personality.

METHODS

The sample comprised a cohort of consecutive PCI patients (N=1234; 72.0% men; mean age 62.0 ± 11.1 years, range [26-90] years) from the Rapamycin-Eluting Stent Evaluated At Rotterdam Cardiology Hospital (RESEARCH) registry. At baseline (i.e., 6 months post-PCI), patients completed the Hospital Anxiety and Depression Scale (HADS) to assess anxiety and depression and the Type D scale (DS14) to assess Type D personality. The endpoint was defined as all-cause mortality.

RESULTS

The prevalence of depression (HADS-D ≥ 8) was 26.2% (324/1236). After a median follow-up of 7.0 ± 1.6 years, 187 deaths (15.2%) from any cause were recorded. The incidence of all-cause mortality in depressed patients was 23.5% (76/324) versus 12.2% (111/910) in non-depressed patients. Cumulative hazard functions differed significantly for depressed versus non-depressed patients (log-rank X(2)=25.57, p<.001). In multivariable analysis, depression remained independently associated with all-cause mortality (HR=1.63; 95% CI [1.05-2.71], p=.038), after adjusting for socio-demographic and clinical characteristics, anxiety, and Type D personality.

CONCLUSIONS

Depression was independently associated with a 1.6-fold increased risk for 7-year mortality, above and beyond anxiety and Type D personality. Future studies are warranted to further elucidate the potential pathways linking depression to long-term mortality following PCI.

Authors+Show Affiliations

Center of Research on Psychology in Somatic diseases, Department of Medical Psychology, Tilburg University, Tilburg, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22560933

Citation

Damen, Nikki L., et al. "Depression Is Independently Associated With 7-year Mortality in Patients Treated With Percutaneous Coronary Intervention: Results From the RESEARCH Registry." International Journal of Cardiology, vol. 167, no. 6, 2013, pp. 2496-501.
Damen NL, Versteeg H, Boersma E, et al. Depression is independently associated with 7-year mortality in patients treated with percutaneous coronary intervention: results from the RESEARCH registry. Int J Cardiol. 2013;167(6):2496-501.
Damen, N. L., Versteeg, H., Boersma, E., Serruys, P. W., van Geuns, R. J., Denollet, J., ... Pedersen, S. S. (2013). Depression is independently associated with 7-year mortality in patients treated with percutaneous coronary intervention: results from the RESEARCH registry. International Journal of Cardiology, 167(6), pp. 2496-501. doi:10.1016/j.ijcard.2012.04.028.
Damen NL, et al. Depression Is Independently Associated With 7-year Mortality in Patients Treated With Percutaneous Coronary Intervention: Results From the RESEARCH Registry. Int J Cardiol. 2013 Sep 10;167(6):2496-501. PubMed PMID: 22560933.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Depression is independently associated with 7-year mortality in patients treated with percutaneous coronary intervention: results from the RESEARCH registry. AU - Damen,Nikki L, AU - Versteeg,Henneke, AU - Boersma,Eric, AU - Serruys,Patrick W, AU - van Geuns,Robert-Jan M, AU - Denollet,Johan, AU - van Domburg,Ron T, AU - Pedersen,Susanne S, Y1 - 2012/05/03/ PY - 2012/02/14/received PY - 2012/03/12/revised PY - 2012/04/08/accepted PY - 2012/5/8/entrez PY - 2012/5/9/pubmed PY - 2014/4/23/medline KW - All-cause mortality KW - Coronary artery disease KW - Depression KW - Percutaneous coronary intervention SP - 2496 EP - 501 JF - International journal of cardiology JO - Int. J. Cardiol. VL - 167 IS - 6 N2 - BACKGROUND: Depression has been associated with poor prognosis in patients with coronary artery disease (CAD), but little is known about the impact of depression on long-term mortality. We examined whether depression was associated with 7-year mortality in patients treated with percutaneous coronary intervention (PCI), after adjusting for socio-demographic and clinical characteristics, anxiety, and the distressed (Type D) personality. METHODS: The sample comprised a cohort of consecutive PCI patients (N=1234; 72.0% men; mean age 62.0 ± 11.1 years, range [26-90] years) from the Rapamycin-Eluting Stent Evaluated At Rotterdam Cardiology Hospital (RESEARCH) registry. At baseline (i.e., 6 months post-PCI), patients completed the Hospital Anxiety and Depression Scale (HADS) to assess anxiety and depression and the Type D scale (DS14) to assess Type D personality. The endpoint was defined as all-cause mortality. RESULTS: The prevalence of depression (HADS-D ≥ 8) was 26.2% (324/1236). After a median follow-up of 7.0 ± 1.6 years, 187 deaths (15.2%) from any cause were recorded. The incidence of all-cause mortality in depressed patients was 23.5% (76/324) versus 12.2% (111/910) in non-depressed patients. Cumulative hazard functions differed significantly for depressed versus non-depressed patients (log-rank X(2)=25.57, p<.001). In multivariable analysis, depression remained independently associated with all-cause mortality (HR=1.63; 95% CI [1.05-2.71], p=.038), after adjusting for socio-demographic and clinical characteristics, anxiety, and Type D personality. CONCLUSIONS: Depression was independently associated with a 1.6-fold increased risk for 7-year mortality, above and beyond anxiety and Type D personality. Future studies are warranted to further elucidate the potential pathways linking depression to long-term mortality following PCI. SN - 1874-1754 UR - https://www.unboundmedicine.com/medline/citation/22560933/Depression_is_independently_associated_with_7_year_mortality_in_patients_treated_with_percutaneous_coronary_intervention:_results_from_the_RESEARCH_registry_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0167-5273(12)00449-4 DB - PRIME DP - Unbound Medicine ER -