Tags

Type your tag names separated by a space and hit enter

Estradiol attenuates the cognitive deficits in the novel object recognition task induced by sub-chronic phencyclidine in ovariectomized rats.
Behav Brain Res. 2012 Jul 15; 233(1):105-12.BB

Abstract

Clinical studies have suggested that estrogens may affect the symptoms of schizophrenia. The novel object recognition task (NORT) in female rats treated with sub-chronic phencyclidine (PCP) was used as an animal model of the cognitive deficits in schizophrenia. The current studies investigated whether chronic estradiol (E) could alleviate sub-chronic PCP-induced cognitive deficits in the NORT. Adult Sprague-Dawley rats were ovariectomized (ovx) and treated with either sub-chronic PCP (2 mg/kg bidaily i.p. for seven days), or with 0.9% saline and their object recognition memory was tested with the NORT using an acquisition trial, 1 min inter-trial interval, and retention trial. Sub-chronic PCP administration did not reliably affect behavior in the acquisition trial but significantly impaired object recognition in the retention trial for 1-2 and 27-29 weeks. Ovx females spent significantly (p<0.05) more time exploring the novel compared to the familiar object, whereas PCP-treated ovx females did not. This effect of PCP was attenuated by long-lasting E capsules implanted prior to PCP treatment. PCP-treated females implanted with E again spent significantly more time exploring the novel compared to the familiar object (p<0.01). When ovx rats were treated with sub-chronic PCP and a long-lasting E capsule was implanted either before or after PCP treatment, estradiol alleviated the PCP-induced deficits when administered in either regimen (p=0.01 and p=0.047 respectively). These data suggest that further exploration of estradiol as a possible therapeutic compound to treat the cognitive deficits of schizophrenia is warranted.

Authors+Show Affiliations

Neuroscience, Oberlin College, 119 Woodland Street, Oberlin, OH 44074, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22561127

Citation

Roseman, Alexander S., et al. "Estradiol Attenuates the Cognitive Deficits in the Novel Object Recognition Task Induced By Sub-chronic Phencyclidine in Ovariectomized Rats." Behavioural Brain Research, vol. 233, no. 1, 2012, pp. 105-12.
Roseman AS, McGregor C, Thornton JE. Estradiol attenuates the cognitive deficits in the novel object recognition task induced by sub-chronic phencyclidine in ovariectomized rats. Behav Brain Res. 2012;233(1):105-12.
Roseman, A. S., McGregor, C., & Thornton, J. E. (2012). Estradiol attenuates the cognitive deficits in the novel object recognition task induced by sub-chronic phencyclidine in ovariectomized rats. Behavioural Brain Research, 233(1), 105-12. https://doi.org/10.1016/j.bbr.2012.04.037
Roseman AS, McGregor C, Thornton JE. Estradiol Attenuates the Cognitive Deficits in the Novel Object Recognition Task Induced By Sub-chronic Phencyclidine in Ovariectomized Rats. Behav Brain Res. 2012 Jul 15;233(1):105-12. PubMed PMID: 22561127.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Estradiol attenuates the cognitive deficits in the novel object recognition task induced by sub-chronic phencyclidine in ovariectomized rats. AU - Roseman,Alexander S, AU - McGregor,Claire, AU - Thornton,Janice E, Y1 - 2012/04/26/ PY - 2011/09/20/received PY - 2012/04/18/revised PY - 2012/04/21/accepted PY - 2012/5/8/entrez PY - 2012/5/9/pubmed PY - 2012/11/6/medline SP - 105 EP - 12 JF - Behavioural brain research JO - Behav Brain Res VL - 233 IS - 1 N2 - Clinical studies have suggested that estrogens may affect the symptoms of schizophrenia. The novel object recognition task (NORT) in female rats treated with sub-chronic phencyclidine (PCP) was used as an animal model of the cognitive deficits in schizophrenia. The current studies investigated whether chronic estradiol (E) could alleviate sub-chronic PCP-induced cognitive deficits in the NORT. Adult Sprague-Dawley rats were ovariectomized (ovx) and treated with either sub-chronic PCP (2 mg/kg bidaily i.p. for seven days), or with 0.9% saline and their object recognition memory was tested with the NORT using an acquisition trial, 1 min inter-trial interval, and retention trial. Sub-chronic PCP administration did not reliably affect behavior in the acquisition trial but significantly impaired object recognition in the retention trial for 1-2 and 27-29 weeks. Ovx females spent significantly (p<0.05) more time exploring the novel compared to the familiar object, whereas PCP-treated ovx females did not. This effect of PCP was attenuated by long-lasting E capsules implanted prior to PCP treatment. PCP-treated females implanted with E again spent significantly more time exploring the novel compared to the familiar object (p<0.01). When ovx rats were treated with sub-chronic PCP and a long-lasting E capsule was implanted either before or after PCP treatment, estradiol alleviated the PCP-induced deficits when administered in either regimen (p=0.01 and p=0.047 respectively). These data suggest that further exploration of estradiol as a possible therapeutic compound to treat the cognitive deficits of schizophrenia is warranted. SN - 1872-7549 UR - https://www.unboundmedicine.com/medline/citation/22561127/Estradiol_attenuates_the_cognitive_deficits_in_the_novel_object_recognition_task_induced_by_sub_chronic_phencyclidine_in_ovariectomized_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(12)00298-7 DB - PRIME DP - Unbound Medicine ER -