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Additive benefits of pneumococcal and influenza vaccines among elderly persons aged 75 years or older in Taiwan--a representative population-based comparative study.

Abstract

OBJECTIVE

It remains unclear whether pneumococcal vaccine provides additional protection to the elderly who have already vaccinated with influenza vaccine. This retrospective cohort study aimed to assess the additive effect of pneumococcal and influenza vaccines on the risk of mortality, hospitalization, and inpatient expenditure in the elderly aged 75 years or older in Taiwan.

METHODS

Data were extracted from the National Health Insurance claims data of a nationally representative elderly sample. To reduce potential selection bias, we employed a propensity score matching method to classify the vaccination status into 3 groups. Multivariable logistic and linear regression models were used to compare the outcomes among different groups.

RESULTS

Each group contained 8142 subjects. The results indicated that an additive effect of receiving both vaccines was associated with a significantly lower all-cause mortality (relative risk [RR]: 0.74; 95% confidence interval [CI]: 0.57-0.96), hospitalization of all diseases including pneumonia, influenza, chronic obstructive pulmonary disease, respiratory diseases, and congestive heart disease (RR: 0.77; 95% CI: 0.67-0.90), and a 13% reduction (95% CI: 0.81-0.94) in inpatient expenditures of all diseases when compared with receiving influenza vaccine alone.

CONCLUSIONS

This study confirmed that vaccination of elderly individuals with pneumococcal vaccine and influenza vaccine concomitantly has substantial beneficial effects.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Healthcare Administration, Asia University, Taichung, Taiwan.

    , , ,

    Source

    The Journal of infection 65:3 2012 Sep pg 231-8

    MeSH

    Aged
    Aged, 80 and over
    Coinfection
    Drug Synergism
    Female
    Hospitalization
    Humans
    Influenza Vaccines
    Influenza, Human
    Linear Models
    Male
    Pneumococcal Infections
    Pneumococcal Vaccines
    Retrospective Studies
    Taiwan

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    22561486

    Citation

    Chang, Yu-Chia, et al. "Additive Benefits of Pneumococcal and Influenza Vaccines Among Elderly Persons Aged 75 Years or Older in Taiwan--a Representative Population-based Comparative Study." The Journal of Infection, vol. 65, no. 3, 2012, pp. 231-8.
    Chang YC, Chou YJ, Liu JY, et al. Additive benefits of pneumococcal and influenza vaccines among elderly persons aged 75 years or older in Taiwan--a representative population-based comparative study. J Infect. 2012;65(3):231-8.
    Chang, Y. C., Chou, Y. J., Liu, J. Y., Yeh, T. F., & Huang, N. (2012). Additive benefits of pneumococcal and influenza vaccines among elderly persons aged 75 years or older in Taiwan--a representative population-based comparative study. The Journal of Infection, 65(3), pp. 231-8. doi:10.1016/j.jinf.2012.04.014.
    Chang YC, et al. Additive Benefits of Pneumococcal and Influenza Vaccines Among Elderly Persons Aged 75 Years or Older in Taiwan--a Representative Population-based Comparative Study. J Infect. 2012;65(3):231-8. PubMed PMID: 22561486.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Additive benefits of pneumococcal and influenza vaccines among elderly persons aged 75 years or older in Taiwan--a representative population-based comparative study. AU - Chang,Yu-Chia, AU - Chou,Yiing-Jenq, AU - Liu,Jen-Yin, AU - Yeh,Te-Feng, AU - Huang,Nicole, Y1 - 2012/05/03/ PY - 2012/01/19/received PY - 2012/03/31/revised PY - 2012/04/27/accepted PY - 2012/5/8/entrez PY - 2012/5/9/pubmed PY - 2013/2/21/medline SP - 231 EP - 8 JF - The Journal of infection JO - J. Infect. VL - 65 IS - 3 N2 - OBJECTIVE: It remains unclear whether pneumococcal vaccine provides additional protection to the elderly who have already vaccinated with influenza vaccine. This retrospective cohort study aimed to assess the additive effect of pneumococcal and influenza vaccines on the risk of mortality, hospitalization, and inpatient expenditure in the elderly aged 75 years or older in Taiwan. METHODS: Data were extracted from the National Health Insurance claims data of a nationally representative elderly sample. To reduce potential selection bias, we employed a propensity score matching method to classify the vaccination status into 3 groups. Multivariable logistic and linear regression models were used to compare the outcomes among different groups. RESULTS: Each group contained 8142 subjects. The results indicated that an additive effect of receiving both vaccines was associated with a significantly lower all-cause mortality (relative risk [RR]: 0.74; 95% confidence interval [CI]: 0.57-0.96), hospitalization of all diseases including pneumonia, influenza, chronic obstructive pulmonary disease, respiratory diseases, and congestive heart disease (RR: 0.77; 95% CI: 0.67-0.90), and a 13% reduction (95% CI: 0.81-0.94) in inpatient expenditures of all diseases when compared with receiving influenza vaccine alone. CONCLUSIONS: This study confirmed that vaccination of elderly individuals with pneumococcal vaccine and influenza vaccine concomitantly has substantial beneficial effects. SN - 1532-2742 UR - https://www.unboundmedicine.com/medline/citation/22561486/Additive_benefits_of_pneumococcal_and_influenza_vaccines_among_elderly_persons_aged_75_years_or_older_in_Taiwan__a_representative_population_based_comparative_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0163-4453(12)00126-0 DB - PRIME DP - Unbound Medicine ER -