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Prevalence of preclinical and clinical heart failure in the elderly. A population-based study in Central Italy.
Eur J Heart Fail 2012; 14(7):718-29EJ

Abstract

AIMS

We conducted a population-based cross-sectional study to assess the prevalence of both preclinical and clinical heart failure (HF) in the elderly.

METHODS AND RESULTS

A sample of 2001 subjects, 65- to 84-year-old residents in the Lazio Region (Italy), underwent physical examination, biochemistry/N-terminal pro brain natriuretic peptide (NT-proBNP) assessment, electrocardiography, and echocardiography. Systolic left ventricular dysfunction (LVD) was defined as left ventricular ejection fraction (LVEF) <50%. Diastolic LVD was defined by a Doppler-derived multiparametric algorithm. The overall prevalence of HF was 6.7% [95% confidence interval (CI) 5.6-7.9], mainly due to HF with preserved LVEF (HFpEF) (4.9%; 95% CI 4.0-5.9), and did not differ by gender. A systolic asymptomatic LVD (ALVD) was detected more frequently in men (1.8%; 95% CI 1.0-2.7) than in women (0.5%; 95% CI 0.1-1.0; P = 0.005), whereas the prevalence of diastolic ALVD was comparable between genders (men: 35.8%; 95% CI = 32.7-38.9; women: 35.0%; 95% CI = 31.9-38.2). The NT-proBNP levels and severity of LVD increased with age. Overall, 1623 subjects (81.1% of the entire studied population) had preclinical HF (Stage A: 22.2% and stage B: 59.1% respectively). A large number of subjects in stage B of HF showed risk factor levels not at target.

CONCLUSIONS

In a population-based study, the prevalence of preclinical HF in the elderly is high. The prevalence of clinical HF is mainly due to HFpEF and is similar between genders.

Authors+Show Affiliations

Department of Cardiovascular Diseases, S. Giovanni-Addolorata Hospital, 00184 Rome, Italy. gfmureddu@tiscali.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22562498

Citation

Mureddu, Gian Francesco, et al. "Prevalence of Preclinical and Clinical Heart Failure in the Elderly. a Population-based Study in Central Italy." European Journal of Heart Failure, vol. 14, no. 7, 2012, pp. 718-29.
Mureddu GF, Agabiti N, Rizzello V, et al. Prevalence of preclinical and clinical heart failure in the elderly. A population-based study in Central Italy. Eur J Heart Fail. 2012;14(7):718-29.
Mureddu, G. F., Agabiti, N., Rizzello, V., Forastiere, F., Latini, R., Cesaroni, G., ... Boccanelli, A. (2012). Prevalence of preclinical and clinical heart failure in the elderly. A population-based study in Central Italy. European Journal of Heart Failure, 14(7), pp. 718-29. doi:10.1093/eurjhf/hfs052.
Mureddu GF, et al. Prevalence of Preclinical and Clinical Heart Failure in the Elderly. a Population-based Study in Central Italy. Eur J Heart Fail. 2012;14(7):718-29. PubMed PMID: 22562498.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of preclinical and clinical heart failure in the elderly. A population-based study in Central Italy. AU - Mureddu,Gian Francesco, AU - Agabiti,Nera, AU - Rizzello,Vittoria, AU - Forastiere,Francesco, AU - Latini,Roberto, AU - Cesaroni,Giulia, AU - Masson,Serge, AU - Cacciatore,Giuseppe, AU - Colivicchi,Furio, AU - Uguccioni,Massimo, AU - Perucci,Carlo Alberto, AU - Boccanelli,Alessandro, AU - ,, Y1 - 2012/05/04/ PY - 2012/5/8/entrez PY - 2012/5/9/pubmed PY - 2012/11/7/medline SP - 718 EP - 29 JF - European journal of heart failure JO - Eur. J. Heart Fail. VL - 14 IS - 7 N2 - AIMS: We conducted a population-based cross-sectional study to assess the prevalence of both preclinical and clinical heart failure (HF) in the elderly. METHODS AND RESULTS: A sample of 2001 subjects, 65- to 84-year-old residents in the Lazio Region (Italy), underwent physical examination, biochemistry/N-terminal pro brain natriuretic peptide (NT-proBNP) assessment, electrocardiography, and echocardiography. Systolic left ventricular dysfunction (LVD) was defined as left ventricular ejection fraction (LVEF) <50%. Diastolic LVD was defined by a Doppler-derived multiparametric algorithm. The overall prevalence of HF was 6.7% [95% confidence interval (CI) 5.6-7.9], mainly due to HF with preserved LVEF (HFpEF) (4.9%; 95% CI 4.0-5.9), and did not differ by gender. A systolic asymptomatic LVD (ALVD) was detected more frequently in men (1.8%; 95% CI 1.0-2.7) than in women (0.5%; 95% CI 0.1-1.0; P = 0.005), whereas the prevalence of diastolic ALVD was comparable between genders (men: 35.8%; 95% CI = 32.7-38.9; women: 35.0%; 95% CI = 31.9-38.2). The NT-proBNP levels and severity of LVD increased with age. Overall, 1623 subjects (81.1% of the entire studied population) had preclinical HF (Stage A: 22.2% and stage B: 59.1% respectively). A large number of subjects in stage B of HF showed risk factor levels not at target. CONCLUSIONS: In a population-based study, the prevalence of preclinical HF in the elderly is high. The prevalence of clinical HF is mainly due to HFpEF and is similar between genders. SN - 1879-0844 UR - https://www.unboundmedicine.com/medline/citation/22562498/Prevalence_of_preclinical_and_clinical_heart_failure_in_the_elderly__A_population_based_study_in_Central_Italy_ L2 - https://doi.org/10.1093/eurjhf/hfs052 DB - PRIME DP - Unbound Medicine ER -