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Alcohol intake and the incidence of non-hodgkin lymphoid neoplasms in the cancer prevention study II nutrition cohort.
Am J Epidemiol 2012; 176(1):60-9AJ

Abstract

Although several studies have shown a lower risk of non-Hodgkin lymphoma (NHL) in alcohol drinkers compared with nondrinkers, the dose-response relation and potential differences between former and current drinking and across beverage types and subtypes are unclear. The authors examined associations of alcohol intake with risk of NHL and NHL subtypes in the Cancer Prevention Study II Nutrition Cohort, a prospective study of US men and women aged 50-74 years. Between 1992 and 2007, there were 1,991 incident NHL cases among 143,124 participants. Multivariable-adjusted relative risks and 95% confidence intervals were computed using Cox proportional hazards regression. Compared with nondrinkers, the relative risk of NHL associated with former drinking was 0.90 (95% confidence interval (CI): 0.75, 1.10); the relative risks associated with current intakes of <1, 1-2, and >2 drinks/day were 0.93 (95% CI: 0.83, 1.03), 0.91 (95% CI: 0.78, 1.06), and 0.78 (95% CI: 0.65, 0.93), respectively. Associations did not differ by sex (P-interaction = 0.45) or beverage type (P-difference = 0.22). Alcohol intake was more strongly associated with B-cell lymphoma (P-trend = 0.005) than with T-cell lymphoma (P-trend = 0.76), and associations were similar among B-cell lymphoma subtypes. In this prospective study, current heavy alcohol intake was associated with a reduced risk of NHL. Associations did not differ by beverage type and were slightly stronger for B-cell tumors than for T-cell tumors.

Authors+Show Affiliations

Epidemiology Research Program, American Cancer Society, 250 Williams Street NW, Atlanta, GA 30303, USA. susan.gapstur@cancer.org

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22562662

Citation

Gapstur, Susan M., et al. "Alcohol Intake and the Incidence of Non-hodgkin Lymphoid Neoplasms in the Cancer Prevention Study II Nutrition Cohort." American Journal of Epidemiology, vol. 176, no. 1, 2012, pp. 60-9.
Gapstur SM, Diver WR, McCullough ML, et al. Alcohol intake and the incidence of non-hodgkin lymphoid neoplasms in the cancer prevention study II nutrition cohort. Am J Epidemiol. 2012;176(1):60-9.
Gapstur, S. M., Diver, W. R., McCullough, M. L., Teras, L. R., Thun, M. J., & Patel, A. V. (2012). Alcohol intake and the incidence of non-hodgkin lymphoid neoplasms in the cancer prevention study II nutrition cohort. American Journal of Epidemiology, 176(1), pp. 60-9. doi:10.1093/aje/kwr497.
Gapstur SM, et al. Alcohol Intake and the Incidence of Non-hodgkin Lymphoid Neoplasms in the Cancer Prevention Study II Nutrition Cohort. Am J Epidemiol. 2012 Jul 1;176(1):60-9. PubMed PMID: 22562662.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol intake and the incidence of non-hodgkin lymphoid neoplasms in the cancer prevention study II nutrition cohort. AU - Gapstur,Susan M, AU - Diver,W Ryan, AU - McCullough,Marjorie L, AU - Teras,Lauren R, AU - Thun,Michael J, AU - Patel,Alpa V, Y1 - 2012/05/04/ PY - 2012/5/8/entrez PY - 2012/5/9/pubmed PY - 2012/9/5/medline SP - 60 EP - 9 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 176 IS - 1 N2 - Although several studies have shown a lower risk of non-Hodgkin lymphoma (NHL) in alcohol drinkers compared with nondrinkers, the dose-response relation and potential differences between former and current drinking and across beverage types and subtypes are unclear. The authors examined associations of alcohol intake with risk of NHL and NHL subtypes in the Cancer Prevention Study II Nutrition Cohort, a prospective study of US men and women aged 50-74 years. Between 1992 and 2007, there were 1,991 incident NHL cases among 143,124 participants. Multivariable-adjusted relative risks and 95% confidence intervals were computed using Cox proportional hazards regression. Compared with nondrinkers, the relative risk of NHL associated with former drinking was 0.90 (95% confidence interval (CI): 0.75, 1.10); the relative risks associated with current intakes of <1, 1-2, and >2 drinks/day were 0.93 (95% CI: 0.83, 1.03), 0.91 (95% CI: 0.78, 1.06), and 0.78 (95% CI: 0.65, 0.93), respectively. Associations did not differ by sex (P-interaction = 0.45) or beverage type (P-difference = 0.22). Alcohol intake was more strongly associated with B-cell lymphoma (P-trend = 0.005) than with T-cell lymphoma (P-trend = 0.76), and associations were similar among B-cell lymphoma subtypes. In this prospective study, current heavy alcohol intake was associated with a reduced risk of NHL. Associations did not differ by beverage type and were slightly stronger for B-cell tumors than for T-cell tumors. SN - 1476-6256 UR - https://www.unboundmedicine.com/medline/citation/22562662/Alcohol_intake_and_the_incidence_of_non_hodgkin_lymphoid_neoplasms_in_the_cancer_prevention_study_II_nutrition_cohort_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwr497 DB - PRIME DP - Unbound Medicine ER -