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Protective effect of sauchinone against regional myocardial ischemia/reperfusion injury: inhibition of p38 MAPK and JNK death signaling pathways.
J Korean Med Sci. 2012 May; 27(5):572-5.JK

Abstract

Sauchinone has been known to have anti-inflammatory and antioxidant effects. We determined whether sauchinone is beneficial in regional myocardial ischemia/reperfusion (I/R) injury. Rats were subjected to 20 min occlusion of the left anterior descending coronary artery, followed by 2 hr reperfusion. Sauchinone (10 mg/kg) was administered intraperitoneally 30 min before the onset of ischemia. The infarct size was measured 2 hr after resuming the perfusion. The expression of cell death kinases (p38 and JNK) and reperfusion injury salvage kinases (phosphatidylinositol-3-OH kinases-Akt, extra-cellular signal-regulated kinases [ERK1/2])/glycogen synthase kinase (GSK)-3β was determined 5 min after resuming the perfusion. Sauchinone significantly reduced the infarct size (29.0% ± 5.3% in the sauchinone group vs 44.4% ± 6.1% in the control, P < 0.05). Accordingly, the phosphorylation of JNK and p38 was significantly attenuated, while that of ERK1/2, Akt and GSK-3β was not affected. It is suggested that sauchinone protects against regional myocardial I/R injury through inhibition of phosphorylation of p38 and JNK death signaling pathways.

Authors+Show Affiliations

Department of Anesthesiology and Pain Medicine, Chonnam National University Medical School, Gwangju, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22563228

Citation

Kim, Seok Jai, et al. "Protective Effect of Sauchinone Against Regional Myocardial Ischemia/reperfusion Injury: Inhibition of P38 MAPK and JNK Death Signaling Pathways." Journal of Korean Medical Science, vol. 27, no. 5, 2012, pp. 572-5.
Kim SJ, Jeong CW, Bae HB, et al. Protective effect of sauchinone against regional myocardial ischemia/reperfusion injury: inhibition of p38 MAPK and JNK death signaling pathways. J Korean Med Sci. 2012;27(5):572-5.
Kim, S. J., Jeong, C. W., Bae, H. B., Kwak, S. H., Son, J. K., Seo, C. S., Lee, H. J., Lee, J., & Yoo, K. Y. (2012). Protective effect of sauchinone against regional myocardial ischemia/reperfusion injury: inhibition of p38 MAPK and JNK death signaling pathways. Journal of Korean Medical Science, 27(5), 572-5. https://doi.org/10.3346/jkms.2012.27.5.572
Kim SJ, et al. Protective Effect of Sauchinone Against Regional Myocardial Ischemia/reperfusion Injury: Inhibition of P38 MAPK and JNK Death Signaling Pathways. J Korean Med Sci. 2012;27(5):572-5. PubMed PMID: 22563228.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective effect of sauchinone against regional myocardial ischemia/reperfusion injury: inhibition of p38 MAPK and JNK death signaling pathways. AU - Kim,Seok Jai, AU - Jeong,Cheol Won, AU - Bae,Hong Beom, AU - Kwak,Sang Hyun, AU - Son,Jong-Keun, AU - Seo,Chang-Seob, AU - Lee,Hyun-Jung, AU - Lee,JongUn, AU - Yoo,Kyung Yeon, Y1 - 2012/04/25/ PY - 2011/04/12/received PY - 2011/07/01/accepted PY - 2012/5/8/entrez PY - 2012/5/9/pubmed PY - 2012/9/1/medline KW - Cardioprotection KW - Cell Death Signaling Pathway KW - Ischemia/reperfusion Injury KW - Reperfusion Injury Salvage Kinase Pathway KW - Sauchinone SP - 572 EP - 5 JF - Journal of Korean medical science JO - J Korean Med Sci VL - 27 IS - 5 N2 - Sauchinone has been known to have anti-inflammatory and antioxidant effects. We determined whether sauchinone is beneficial in regional myocardial ischemia/reperfusion (I/R) injury. Rats were subjected to 20 min occlusion of the left anterior descending coronary artery, followed by 2 hr reperfusion. Sauchinone (10 mg/kg) was administered intraperitoneally 30 min before the onset of ischemia. The infarct size was measured 2 hr after resuming the perfusion. The expression of cell death kinases (p38 and JNK) and reperfusion injury salvage kinases (phosphatidylinositol-3-OH kinases-Akt, extra-cellular signal-regulated kinases [ERK1/2])/glycogen synthase kinase (GSK)-3β was determined 5 min after resuming the perfusion. Sauchinone significantly reduced the infarct size (29.0% ± 5.3% in the sauchinone group vs 44.4% ± 6.1% in the control, P < 0.05). Accordingly, the phosphorylation of JNK and p38 was significantly attenuated, while that of ERK1/2, Akt and GSK-3β was not affected. It is suggested that sauchinone protects against regional myocardial I/R injury through inhibition of phosphorylation of p38 and JNK death signaling pathways. SN - 1598-6357 UR - https://www.unboundmedicine.com/medline/citation/22563228/Protective_effect_of_sauchinone_against_regional_myocardial_ischemia/reperfusion_injury:_inhibition_of_p38_MAPK_and_JNK_death_signaling_pathways_ L2 - https://jkms.org/DOIx.php?id=10.3346/jkms.2012.27.5.572 DB - PRIME DP - Unbound Medicine ER -