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Prevalence of hepatitis C virus infections and distribution of hepatitis C virus genotypes among Korean blood donors.
Ann Lab Med. 2012 May; 32(3):210-5.AL

Abstract

BACKGROUND

Hepatitis C virus (HCV) remains a worldwide health-care burden. Prevalence rates vary and the distribution of genotypes depends on geographical location. Here, the recent prevalence of HCV infections and distribution of HCV genotypes among Korean blood donors were studied.

METHODS

Between February 2005 and December 2009, a total of 11,064,532 donors were screened for anti-HCV and 11,412,690 donors were screened for HCV RNA. HCV genotyping was conducted for 748 blood donors with HCV RNA by using the line probe assay (VERSANT HCV Genotype 2.0 Assay, Bayer Healthcare, USA) after amplification of the 5'-untranslated and core regions of the genome.

RESULTS

The anti-HCV prevalence was 0.16% (17,250/11,064,532). HCV RNA was detected in 959 out of the 11,412,690 donors (8.4/100,000). HCV RNA was more prevalent among women, donors who resided at harbor sites, and first-time donors. In addition, the prevalence of HCV RNA increased with age. The genotypes of 740 out of the 748 tested donors (98.9%) were identified. HCV genotype 1b (47.7%) and 2a/2c (35.0%) were dominant. Genotypes 2 (7.6%), 2b (2.3%), 3a (1.6%), 1a (1.3%), 1 (0.9%), 2v (0.5%), 1v (0.1%), and 3 (0.1%) were also identified. Genotype 4a/4c/4d (0.1%) was detected for the first time in one Korean blood donor.

CONCLUSIONS

The distribution of HCV genotypes in Korea has not changed remarkably, with the exception of genotype 4a/4c/4d. A periodic study to monitor the prevalence of HCV infections and the distribution of HCV genotypes is required to identify emerging genotypes in Korea.

Authors+Show Affiliations

Central Blood Laboratory Center, Korean Red Cross, Seoul, Korea. dj57_2000@redcross.or.krNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22563557

Citation

Oh, Deok Ja, et al. "Prevalence of Hepatitis C Virus Infections and Distribution of Hepatitis C Virus Genotypes Among Korean Blood Donors." Annals of Laboratory Medicine, vol. 32, no. 3, 2012, pp. 210-5.
Oh DJ, Park YM, Seo YI, et al. Prevalence of hepatitis C virus infections and distribution of hepatitis C virus genotypes among Korean blood donors. Ann Lab Med. 2012;32(3):210-5.
Oh, D. J., Park, Y. M., Seo, Y. I., Lee, J. S., & Lee, J. Y. (2012). Prevalence of hepatitis C virus infections and distribution of hepatitis C virus genotypes among Korean blood donors. Annals of Laboratory Medicine, 32(3), 210-5. https://doi.org/10.3343/alm.2012.32.3.210
Oh DJ, et al. Prevalence of Hepatitis C Virus Infections and Distribution of Hepatitis C Virus Genotypes Among Korean Blood Donors. Ann Lab Med. 2012;32(3):210-5. PubMed PMID: 22563557.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of hepatitis C virus infections and distribution of hepatitis C virus genotypes among Korean blood donors. AU - Oh,Deok Ja, AU - Park,Yoon Mee, AU - Seo,Young Ik, AU - Lee,Jae Sook, AU - Lee,Ja Young, Y1 - 2012/04/18/ PY - 2011/08/31/received PY - 2012/01/27/revised PY - 2012/02/08/accepted PY - 2012/5/8/entrez PY - 2012/5/9/pubmed PY - 2012/8/31/medline KW - Anti-HCV KW - HCV RNA KW - HCV genotype KW - Hepatitis C virus (HCV) KW - Prevalence SP - 210 EP - 5 JF - Annals of laboratory medicine JO - Ann Lab Med VL - 32 IS - 3 N2 - BACKGROUND: Hepatitis C virus (HCV) remains a worldwide health-care burden. Prevalence rates vary and the distribution of genotypes depends on geographical location. Here, the recent prevalence of HCV infections and distribution of HCV genotypes among Korean blood donors were studied. METHODS: Between February 2005 and December 2009, a total of 11,064,532 donors were screened for anti-HCV and 11,412,690 donors were screened for HCV RNA. HCV genotyping was conducted for 748 blood donors with HCV RNA by using the line probe assay (VERSANT HCV Genotype 2.0 Assay, Bayer Healthcare, USA) after amplification of the 5'-untranslated and core regions of the genome. RESULTS: The anti-HCV prevalence was 0.16% (17,250/11,064,532). HCV RNA was detected in 959 out of the 11,412,690 donors (8.4/100,000). HCV RNA was more prevalent among women, donors who resided at harbor sites, and first-time donors. In addition, the prevalence of HCV RNA increased with age. The genotypes of 740 out of the 748 tested donors (98.9%) were identified. HCV genotype 1b (47.7%) and 2a/2c (35.0%) were dominant. Genotypes 2 (7.6%), 2b (2.3%), 3a (1.6%), 1a (1.3%), 1 (0.9%), 2v (0.5%), 1v (0.1%), and 3 (0.1%) were also identified. Genotype 4a/4c/4d (0.1%) was detected for the first time in one Korean blood donor. CONCLUSIONS: The distribution of HCV genotypes in Korea has not changed remarkably, with the exception of genotype 4a/4c/4d. A periodic study to monitor the prevalence of HCV infections and the distribution of HCV genotypes is required to identify emerging genotypes in Korea. SN - 2234-3814 UR - https://www.unboundmedicine.com/medline/citation/22563557/Prevalence_of_hepatitis_C_virus_infections_and_distribution_of_hepatitis_C_virus_genotypes_among_Korean_blood_donors_ L2 - http://www.annlabmed.org/journal/viewJournal.html?year=2012&vol=32&page=210 DB - PRIME DP - Unbound Medicine ER -