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Relationships between sarcopenic obesity and insulin resistance, inflammation, and vitamin D status: the Korean Sarcopenic Obesity Study.
Clin Endocrinol (Oxf). 2013 Apr; 78(4):525-32.CE

Abstract

OBJECTIVE

It has been suggested that insulin resistance, low-grade inflammation and vitamin D deficiency are associated with obesity and sarcopenia. However, their relationships with sarcopenic obesity (SO) are unclear. We evaluated the impact of homoeostasis model assessment of insulin resistance (HOMA-IR), high-sensitivity C-reactive protein (hsCRP) and 25-hydroxyvitamin D (25[OH]D) levels on SO in Korean adults. STUDY SUBJECT/MEASUREMENTS: This study included 493 apparently healthy adults (180 men and 313 women) enrolled in the Korean Sarcopenic Obesity Study. Sarcopenia was defined as a skeletal muscle mass index (SMI) of 1 SD below the sex-specific mean value for a young reference group. Obesity was defined as a visceral fat area (VFA) ≥100 cm(2) . We classified the participants into four sarcopenia/obesity groups based on both SMI and VFA.

RESULTS

The prevalence of SO was 17·8% in men and 24·9% in women. In women, the SO group had higher HOMA-IR and hsCRP levels compared with the non-SO group. In men, the 25[OH]D levels were significantly lower in the SO group than the non-SO group. Both hsCRP and HOMA-IR levels were negatively correlated with SMI and positively correlated with VFA in both men and women, whereas 25[OH]D levels were positively correlated with SMI in both men and women. Multiple binary logistic regression analysis showed that HOMA-IR and 25[OH]D levels were independently associated with SO in men, while HOMA-IR and hsCRP were significant factors predicting SO in women.

CONCLUSION

Insulin resistance, inflammation and vitamin D deficiency were associated with SO in a Korean adult population.

Authors+Show Affiliations

Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Korea University, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22563924

Citation

Kim, Tae Nyun, et al. "Relationships Between Sarcopenic Obesity and Insulin Resistance, Inflammation, and Vitamin D Status: the Korean Sarcopenic Obesity Study." Clinical Endocrinology, vol. 78, no. 4, 2013, pp. 525-32.
Kim TN, Park MS, Lim KI, et al. Relationships between sarcopenic obesity and insulin resistance, inflammation, and vitamin D status: the Korean Sarcopenic Obesity Study. Clin Endocrinol (Oxf). 2013;78(4):525-32.
Kim, T. N., Park, M. S., Lim, K. I., Choi, H. Y., Yang, S. J., Yoo, H. J., Kang, H. J., Song, W., Choi, H., Baik, S. H., Choi, D. S., & Choi, K. M. (2013). Relationships between sarcopenic obesity and insulin resistance, inflammation, and vitamin D status: the Korean Sarcopenic Obesity Study. Clinical Endocrinology, 78(4), 525-32. https://doi.org/10.1111/j.1365-2265.2012.04433.x
Kim TN, et al. Relationships Between Sarcopenic Obesity and Insulin Resistance, Inflammation, and Vitamin D Status: the Korean Sarcopenic Obesity Study. Clin Endocrinol (Oxf). 2013;78(4):525-32. PubMed PMID: 22563924.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationships between sarcopenic obesity and insulin resistance, inflammation, and vitamin D status: the Korean Sarcopenic Obesity Study. AU - Kim,Tae Nyun, AU - Park,Man Sik, AU - Lim,Kang Il, AU - Choi,Hae Yoon, AU - Yang,Sae Jeong, AU - Yoo,Hye Jin, AU - Kang,Hyun Joo, AU - Song,Wook, AU - Choi,Hyuk, AU - Baik,Sei Hyun, AU - Choi,Dong Seop, AU - Choi,Kyung Mook, PY - 2012/11/28/received PY - 2012/01/03/revised PY - 2012/04/18/revised PY - 2012/05/01/accepted PY - 2012/5/9/entrez PY - 2012/5/9/pubmed PY - 2013/9/13/medline SP - 525 EP - 32 JF - Clinical endocrinology JO - Clin. Endocrinol. (Oxf) VL - 78 IS - 4 N2 - OBJECTIVE: It has been suggested that insulin resistance, low-grade inflammation and vitamin D deficiency are associated with obesity and sarcopenia. However, their relationships with sarcopenic obesity (SO) are unclear. We evaluated the impact of homoeostasis model assessment of insulin resistance (HOMA-IR), high-sensitivity C-reactive protein (hsCRP) and 25-hydroxyvitamin D (25[OH]D) levels on SO in Korean adults. STUDY SUBJECT/MEASUREMENTS: This study included 493 apparently healthy adults (180 men and 313 women) enrolled in the Korean Sarcopenic Obesity Study. Sarcopenia was defined as a skeletal muscle mass index (SMI) of 1 SD below the sex-specific mean value for a young reference group. Obesity was defined as a visceral fat area (VFA) ≥100 cm(2) . We classified the participants into four sarcopenia/obesity groups based on both SMI and VFA. RESULTS: The prevalence of SO was 17·8% in men and 24·9% in women. In women, the SO group had higher HOMA-IR and hsCRP levels compared with the non-SO group. In men, the 25[OH]D levels were significantly lower in the SO group than the non-SO group. Both hsCRP and HOMA-IR levels were negatively correlated with SMI and positively correlated with VFA in both men and women, whereas 25[OH]D levels were positively correlated with SMI in both men and women. Multiple binary logistic regression analysis showed that HOMA-IR and 25[OH]D levels were independently associated with SO in men, while HOMA-IR and hsCRP were significant factors predicting SO in women. CONCLUSION: Insulin resistance, inflammation and vitamin D deficiency were associated with SO in a Korean adult population. SN - 1365-2265 UR - https://www.unboundmedicine.com/medline/citation/22563924/Relationships_between_sarcopenic_obesity_and_insulin_resistance_inflammation_and_vitamin_D_status:_the_Korean_Sarcopenic_Obesity_Study_ L2 - https://doi.org/10.1111/j.1365-2265.2012.04433.x DB - PRIME DP - Unbound Medicine ER -