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Viral disruption of the blood-brain barrier.

Abstract

The blood-brain barrier (BBB) provides significant protection against microbial invasion of the brain. However, the BBB is not impenetrable, and mechanisms by which viruses breach it are becoming clearer. In vivo and in vitro model systems are enabling identification of host and viral factors contributing to breakdown of the unique BBB tight junctions. Key mechanisms of tight junction damage from inside and outside cells are disruption of the actin cytoskeleton and matrix metalloproteinase activity, respectively. Viral proteins acting in BBB disruption are described for HIV-1, currently the most studied encephalitic virus; other viruses are also discussed.

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  • Authors+Show Affiliations

    ,

    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109-5620, USA. krspin@umich.edu

    Source

    Trends in microbiology 20:6 2012 Jun pg 282-90

    MeSH

    Animals
    Blood-Brain Barrier
    Cytological Techniques
    DNA Viruses
    Disease Models, Animal
    Humans
    Models, Biological
    RNA Viruses

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    22564250