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Preventive effects of North American ginseng (Panax quinquefolius) on diabetic retinopathy and cardiomyopathy.
Phytother Res 2013; 27(2):290-8PR

Abstract

Ginseng (Araliaceae) has multiple pharmacological actions because of its diverse phytochemical constituents. The aims of the present study are to evaluate the preventive effects of North American ginseng on diabetic retinopathy and cardiomyopathy and to delineate the underlying mechanisms of such effects. Models of both type 1 (C57BL/6 mice with streptozotocin-induced diabetes) and type 2 diabetes (db/db mice) and age-matched and sex-matched controls were examined. Alcoholic ginseng root (200 mg/kg body weight, daily oral gavage) extract was administered to groups of both type 1 and type 2 diabetic mice for 2 or 4 months. Dysmetabolic state in the diabetic mice was significantly improved by ginseng treatment. In both the heart and retina of diabetic animals, ginseng treatment significantly prevented oxidative stress and diabetes-induced upregulations of extracellular matrix proteins and vasoactive factors. Ginseng treatment in the diabetic animals resulted in enhancement of stroke volume, ejection fraction, cardiac output, and left ventricle pressure during systole and diastole and diminution of stroke work. In addition, mRNA expressions of atrial natriuretic factor and brain natriuretic factor (molecular markers for cardiac hypertrophy) were significantly diminished in ginseng-treated diabetic mice. These data indicate that North American ginseng prevents the diabetes-induced retinal and cardiac biochemical and functional changes probably through inhibition of oxidative stress.

Authors+Show Affiliations

Dept. of Pathology, University of Western Ontario, London, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22566158

Citation

Sen, Subhrojit, et al. "Preventive Effects of North American Ginseng (Panax Quinquefolius) On Diabetic Retinopathy and Cardiomyopathy." Phytotherapy Research : PTR, vol. 27, no. 2, 2013, pp. 290-8.
Sen S, Chen S, Wu Y, et al. Preventive effects of North American ginseng (Panax quinquefolius) on diabetic retinopathy and cardiomyopathy. Phytother Res. 2013;27(2):290-8.
Sen, S., Chen, S., Wu, Y., Feng, B., Lui, E. K., & Chakrabarti, S. (2013). Preventive effects of North American ginseng (Panax quinquefolius) on diabetic retinopathy and cardiomyopathy. Phytotherapy Research : PTR, 27(2), pp. 290-8. doi:10.1002/ptr.4719.
Sen S, et al. Preventive Effects of North American Ginseng (Panax Quinquefolius) On Diabetic Retinopathy and Cardiomyopathy. Phytother Res. 2013;27(2):290-8. PubMed PMID: 22566158.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preventive effects of North American ginseng (Panax quinquefolius) on diabetic retinopathy and cardiomyopathy. AU - Sen,Subhrojit, AU - Chen,Shali, AU - Wu,Yuexiu, AU - Feng,Biao, AU - Lui,Edmund K, AU - Chakrabarti,Subrata, Y1 - 2012/05/08/ PY - 2012/02/06/received PY - 2012/03/27/revised PY - 2012/04/13/accepted PY - 2012/5/9/entrez PY - 2012/5/9/pubmed PY - 2013/5/15/medline SP - 290 EP - 8 JF - Phytotherapy research : PTR JO - Phytother Res VL - 27 IS - 2 N2 - Ginseng (Araliaceae) has multiple pharmacological actions because of its diverse phytochemical constituents. The aims of the present study are to evaluate the preventive effects of North American ginseng on diabetic retinopathy and cardiomyopathy and to delineate the underlying mechanisms of such effects. Models of both type 1 (C57BL/6 mice with streptozotocin-induced diabetes) and type 2 diabetes (db/db mice) and age-matched and sex-matched controls were examined. Alcoholic ginseng root (200 mg/kg body weight, daily oral gavage) extract was administered to groups of both type 1 and type 2 diabetic mice for 2 or 4 months. Dysmetabolic state in the diabetic mice was significantly improved by ginseng treatment. In both the heart and retina of diabetic animals, ginseng treatment significantly prevented oxidative stress and diabetes-induced upregulations of extracellular matrix proteins and vasoactive factors. Ginseng treatment in the diabetic animals resulted in enhancement of stroke volume, ejection fraction, cardiac output, and left ventricle pressure during systole and diastole and diminution of stroke work. In addition, mRNA expressions of atrial natriuretic factor and brain natriuretic factor (molecular markers for cardiac hypertrophy) were significantly diminished in ginseng-treated diabetic mice. These data indicate that North American ginseng prevents the diabetes-induced retinal and cardiac biochemical and functional changes probably through inhibition of oxidative stress. SN - 1099-1573 UR - https://www.unboundmedicine.com/medline/citation/22566158/Preventive_effects_of_North_American_ginseng__Panax_quinquefolius__on_diabetic_retinopathy_and_cardiomyopathy_ L2 - https://doi.org/10.1002/ptr.4719 DB - PRIME DP - Unbound Medicine ER -