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An improvement in physicochemical properties of carvedilol through spherically agglomerated solid dispersions with PVP K30.
Acta Pol Pharm. 2012 Mar-Apr; 69(2):299-308.AP

Abstract

Spherically agglomerated solid dispersions of carvedilol (CAR) were prepared with polyvinyl-pyrrolidone (PVP) using acetone, water and dichloromethane as solvent, non-solvent and bridging liquid, respectively. The prepared agglomerates were evaluated for its percentage yield, drug content, morphology, thermal behavior, micromeritic properties, aqueous solubility and in vitro drug release. Differential scanning calorimetric and powder X-ray diffraction studies confirm that formulation process altered the crystalline nature of carvedilol. The recrystallized agglomerates exhibited significant increase (p < 0.05) in micromeritic properties than untreated carvedilol. Solubility and in vitro drug release studies indicated that the spherical agglomerates showed significant increase (p < 0.05) in solubility and dissolution rate than pure carvedilol alone.

Authors+Show Affiliations

Sudhakarrao Naik Institute of Pharmacy, Pusad-445204, Dist. Yavatmal, Maharashtra, India. amit.tapas@gmail.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22568045

Citation

Tapas, Amit, et al. "An Improvement in Physicochemical Properties of Carvedilol Through Spherically Agglomerated Solid Dispersions With PVP K30." Acta Poloniae Pharmaceutica, vol. 69, no. 2, 2012, pp. 299-308.
Tapas A, Kawtikwar P, Sakarkar D. An improvement in physicochemical properties of carvedilol through spherically agglomerated solid dispersions with PVP K30. Acta Pol Pharm. 2012;69(2):299-308.
Tapas, A., Kawtikwar, P., & Sakarkar, D. (2012). An improvement in physicochemical properties of carvedilol through spherically agglomerated solid dispersions with PVP K30. Acta Poloniae Pharmaceutica, 69(2), 299-308.
Tapas A, Kawtikwar P, Sakarkar D. An Improvement in Physicochemical Properties of Carvedilol Through Spherically Agglomerated Solid Dispersions With PVP K30. Acta Pol Pharm. 2012 Mar-Apr;69(2):299-308. PubMed PMID: 22568045.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An improvement in physicochemical properties of carvedilol through spherically agglomerated solid dispersions with PVP K30. AU - Tapas,Amit, AU - Kawtikwar,Pravin, AU - Sakarkar,Dinesh, PY - 2012/5/10/entrez PY - 2012/5/10/pubmed PY - 2012/6/1/medline SP - 299 EP - 308 JF - Acta poloniae pharmaceutica JO - Acta Pol Pharm VL - 69 IS - 2 N2 - Spherically agglomerated solid dispersions of carvedilol (CAR) were prepared with polyvinyl-pyrrolidone (PVP) using acetone, water and dichloromethane as solvent, non-solvent and bridging liquid, respectively. The prepared agglomerates were evaluated for its percentage yield, drug content, morphology, thermal behavior, micromeritic properties, aqueous solubility and in vitro drug release. Differential scanning calorimetric and powder X-ray diffraction studies confirm that formulation process altered the crystalline nature of carvedilol. The recrystallized agglomerates exhibited significant increase (p < 0.05) in micromeritic properties than untreated carvedilol. Solubility and in vitro drug release studies indicated that the spherical agglomerates showed significant increase (p < 0.05) in solubility and dissolution rate than pure carvedilol alone. SN - 0001-6837 UR - https://www.unboundmedicine.com/medline/citation/22568045/An_improvement_in_physicochemical_properties_of_carvedilol_through_spherically_agglomerated_solid_dispersions_with_PVP_K30_ L2 - http://www.ptfarm.pl/pub/File/Acta_Poloniae/2012/2/299.pdf DB - PRIME DP - Unbound Medicine ER -