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[Role of septin cytoskeleton in dopaminergic neurotransmission and neurodegeneration].

Abstract

Cytoskeletal polymers play pleiotropic roles in neuroglial morphogenesis, intracellular transport, organization of pre- and post-synaptic scaffolds, etc. Thus, neuroglial dysfunction and degeneration are often accompanied by abnormalities in microtubules, actin and/or intermediate filament systems. Although our understanding of an unconventional cytoskeletal system composed of the septin family of GTP-binding proteins is far behind, recent studies have been revealing that qualitative and/or quantitative abnormalities of septins are also associated with neurodegenerative disorders including hereditary neuralgic amyotrophy, Parkinson disease, schizophrenia and bipolar disorder. A better understanding of the physiological and pathophysiological roles of the septin system should help develop useful biomarkers and therapeutic strategies for these diseases.

Authors+Show Affiliations

Division of Biological Science, Graduate School of Science, Nagoya University, Nagoya, Japan. kinoshita.makoto@c.mbox.nayoya-u.ac.jp

Source

MeSH

Animals
Dopamine
Dopamine Plasma Membrane Transport Proteins
Humans
Mice
Neurodegenerative Diseases
Parkinson Disease
Septins
Synaptic Transmission
alpha-Synuclein

Pub Type(s)

English Abstract
Journal Article
Review

Language

jpn

PubMed ID

22568123