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Host cell factor 1 inhibits SKN-1 to modulate oxidative stress responses in Caenorhabditis elegans.
Aging Cell. 2012 Aug; 11(4):717-21.AC

Abstract

Host cell factor-1 (HCF-1) is a conserved regulator of the longevity and stress response functions of DAF-16/FOXO. SKN-1 transcription factor is an evolutionarily conserved xenobiotic stress regulator and a pro-longevity factor. Here, we demonstrate that SKN-1 contributes to the enhanced oxidative stress resistance incurred by hcf-1 mutation in C. elegans. HCF-1 prevents the nuclear accumulation of SKN-1 and represses the transcriptional activation of SKN-1 specifically at target genes involved in cellular detoxification pathways. Our findings reveal a novel and context-specific regulatory relationship between two highly conserved longevity and stress response factors HCF-1 and SKN-1.

Authors+Show Affiliations

Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22568582

Citation

Rizki, Gizem, et al. "Host Cell Factor 1 Inhibits SKN-1 to Modulate Oxidative Stress Responses in Caenorhabditis Elegans." Aging Cell, vol. 11, no. 4, 2012, pp. 717-21.
Rizki G, Picard CL, Pereyra C, et al. Host cell factor 1 inhibits SKN-1 to modulate oxidative stress responses in Caenorhabditis elegans. Aging Cell. 2012;11(4):717-21.
Rizki, G., Picard, C. L., Pereyra, C., & Lee, S. S. (2012). Host cell factor 1 inhibits SKN-1 to modulate oxidative stress responses in Caenorhabditis elegans. Aging Cell, 11(4), 717-21. https://doi.org/10.1111/j.1474-9726.2012.00831.x
Rizki G, et al. Host Cell Factor 1 Inhibits SKN-1 to Modulate Oxidative Stress Responses in Caenorhabditis Elegans. Aging Cell. 2012;11(4):717-21. PubMed PMID: 22568582.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Host cell factor 1 inhibits SKN-1 to modulate oxidative stress responses in Caenorhabditis elegans. AU - Rizki,Gizem, AU - Picard,Colette Lafontaine, AU - Pereyra,Charles, AU - Lee,Siu Sylvia, Y1 - 2012/06/04/ PY - 2012/5/10/entrez PY - 2012/5/10/pubmed PY - 2012/11/14/medline SP - 717 EP - 21 JF - Aging cell JO - Aging Cell VL - 11 IS - 4 N2 - Host cell factor-1 (HCF-1) is a conserved regulator of the longevity and stress response functions of DAF-16/FOXO. SKN-1 transcription factor is an evolutionarily conserved xenobiotic stress regulator and a pro-longevity factor. Here, we demonstrate that SKN-1 contributes to the enhanced oxidative stress resistance incurred by hcf-1 mutation in C. elegans. HCF-1 prevents the nuclear accumulation of SKN-1 and represses the transcriptional activation of SKN-1 specifically at target genes involved in cellular detoxification pathways. Our findings reveal a novel and context-specific regulatory relationship between two highly conserved longevity and stress response factors HCF-1 and SKN-1. SN - 1474-9726 UR - https://www.unboundmedicine.com/medline/citation/22568582/Host_cell_factor_1_inhibits_SKN_1_to_modulate_oxidative_stress_responses_in_Caenorhabditis_elegans_ L2 - https://doi.org/10.1111/j.1474-9726.2012.00831.x DB - PRIME DP - Unbound Medicine ER -