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Health implications of high dietary omega-6 polyunsaturated Fatty acids.
J Nutr Metab. 2012; 2012:539426.JN

Abstract

Omega-6 (n-6) polyunsaturated fatty acids (PUFA) (e.g., arachidonic acid (AA)) and omega-3 (n-3) PUFA (e.g., eicosapentaenoic acid (EPA)) are precursors to potent lipid mediator signalling molecules, termed "eicosanoids," which have important roles in the regulation of inflammation. In general, eicosanoids derived from n-6 PUFA are proinflammatory while eicosanoids derived from n-3 PUFA are anti-inflammatory. Dietary changes over the past few decades in the intake of n-6 and n-3 PUFA show striking increases in the (n-6) to (n-3) ratio (~15 : 1), which are associated with greater metabolism of the n-6 PUFA compared with n-3 PUFA. Coinciding with this increase in the ratio of (n-6) : (n-3) PUFA are increases in chronic inflammatory diseases such as nonalcoholic fatty liver disease (NAFLD), cardiovascular disease, obesity, inflammatory bowel disease (IBD), rheumatoid arthritis, and Alzheimer's disease (AD). By increasing the ratio of (n-3) : (n-6) PUFA in the Western diet, reductions may be achieved in the incidence of these chronic inflammatory diseases.

Authors+Show Affiliations

Alimentary Pharmabiotic Centre, Biosciences Institute, County Cork, Ireland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22570770

Citation

Patterson, E, et al. "Health Implications of High Dietary Omega-6 Polyunsaturated Fatty Acids." Journal of Nutrition and Metabolism, vol. 2012, 2012, p. 539426.
Patterson E, Wall R, Fitzgerald GF, et al. Health implications of high dietary omega-6 polyunsaturated Fatty acids. Journal of nutrition and metabolism. 2012;2012:539426.
Patterson, E., Wall, R., Fitzgerald, G. F., Ross, R. P., & Stanton, C. (2012). Health implications of high dietary omega-6 polyunsaturated Fatty acids. Journal of Nutrition and Metabolism, 2012, 539426. https://doi.org/10.1155/2012/539426
Patterson E, et al. Health Implications of High Dietary Omega-6 Polyunsaturated Fatty Acids. Journal of nutrition and metabolism. 2012;2012:539426. PubMed PMID: 22570770.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Health implications of high dietary omega-6 polyunsaturated Fatty acids. AU - Patterson,E, AU - Wall,R, AU - Fitzgerald,G F, AU - Ross,R P, AU - Stanton,C, Y1 - 2012/04/05/ PY - 2011/07/28/received PY - 2011/11/17/revised PY - 2011/11/20/accepted PY - 2012/5/10/entrez PY - 2012/5/10/pubmed PY - 2012/5/10/medline SP - 539426 EP - 539426 JF - Journal of nutrition and metabolism VL - 2012 N2 - Omega-6 (n-6) polyunsaturated fatty acids (PUFA) (e.g., arachidonic acid (AA)) and omega-3 (n-3) PUFA (e.g., eicosapentaenoic acid (EPA)) are precursors to potent lipid mediator signalling molecules, termed "eicosanoids," which have important roles in the regulation of inflammation. In general, eicosanoids derived from n-6 PUFA are proinflammatory while eicosanoids derived from n-3 PUFA are anti-inflammatory. Dietary changes over the past few decades in the intake of n-6 and n-3 PUFA show striking increases in the (n-6) to (n-3) ratio (~15 : 1), which are associated with greater metabolism of the n-6 PUFA compared with n-3 PUFA. Coinciding with this increase in the ratio of (n-6) : (n-3) PUFA are increases in chronic inflammatory diseases such as nonalcoholic fatty liver disease (NAFLD), cardiovascular disease, obesity, inflammatory bowel disease (IBD), rheumatoid arthritis, and Alzheimer's disease (AD). By increasing the ratio of (n-3) : (n-6) PUFA in the Western diet, reductions may be achieved in the incidence of these chronic inflammatory diseases. SN - 2090-0732 UR - https://www.unboundmedicine.com/medline/citation/22570770/Health_implications_of_high_dietary_omega_6_polyunsaturated_Fatty_acids_ L2 - https://doi.org/10.1155/2012/539426 DB - PRIME DP - Unbound Medicine ER -
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