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In vivo wound healing effects of Symphytum officinale L. leaves extract in different topical formulations.
Pharmazie 2012; 67(4):355-60P

Abstract

The present work evaluates wound healing activity of leaves extracts of Symphytum officinale L. (comfrey) incorporated in three pharmaceutical formulations. Wound healing activity of comfrey was determined by qualitative and quantitative histological analysis of open wound in rat model, using allantoin as positive control. Three topical formulations, carbomer gel, glycero-alcoholic solution and O/W emulsion (soft lotion) were compared. The histological analysis of the healing process shows significant differences in treatment, particularly on its intensity and rate. The results indicate that emulsion containing both extracts, commercial and prepared, induced the largest and furthest repair of damaged tissue. This could be evidenced from day 3 to 28 by increase in collagen deposition from 40% to 240% and reduction on cellular inflammatory infiltrate from 3% to 46%. However, 8% prepared extract in emulsion presented the best efficacy. This work clearly demonstrates that comfrey leaves have a wound healing activity. The O/W emulsion showed to be the vehicle most effective to induce healing activity, particularly with extracts obtained from comfrey leaves collected in Minas Gerais state in Brazil. It shows the best efficacy to control the inflammatory process and to induce collagen deposition at 8% concentration.

Authors+Show Affiliations

Departamento de Farmácia, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Brasil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22570943

Citation

Araújo, L U., et al. "In Vivo Wound Healing Effects of Symphytum Officinale L. Leaves Extract in Different Topical Formulations." Die Pharmazie, vol. 67, no. 4, 2012, pp. 355-60.
Araújo LU, Reis PG, Barbosa LC, et al. In vivo wound healing effects of Symphytum officinale L. leaves extract in different topical formulations. Pharmazie. 2012;67(4):355-60.
Araújo, L. U., Reis, P. G., Barbosa, L. C., Saúde-Guimarães, D. A., Grabe-Guimarães, A., Mosqueira, V. C., ... Silva-Barcellos, N. M. (2012). In vivo wound healing effects of Symphytum officinale L. leaves extract in different topical formulations. Die Pharmazie, 67(4), pp. 355-60.
Araújo LU, et al. In Vivo Wound Healing Effects of Symphytum Officinale L. Leaves Extract in Different Topical Formulations. Pharmazie. 2012;67(4):355-60. PubMed PMID: 22570943.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vivo wound healing effects of Symphytum officinale L. leaves extract in different topical formulations. AU - Araújo,L U, AU - Reis,P G, AU - Barbosa,L C O, AU - Saúde-Guimarães,D A, AU - Grabe-Guimarães,A, AU - Mosqueira,V C F, AU - Carneiro,C M, AU - Silva-Barcellos,N M, PY - 2012/5/11/entrez PY - 2012/5/11/pubmed PY - 2012/6/5/medline SP - 355 EP - 60 JF - Die Pharmazie JO - Pharmazie VL - 67 IS - 4 N2 - The present work evaluates wound healing activity of leaves extracts of Symphytum officinale L. (comfrey) incorporated in three pharmaceutical formulations. Wound healing activity of comfrey was determined by qualitative and quantitative histological analysis of open wound in rat model, using allantoin as positive control. Three topical formulations, carbomer gel, glycero-alcoholic solution and O/W emulsion (soft lotion) were compared. The histological analysis of the healing process shows significant differences in treatment, particularly on its intensity and rate. The results indicate that emulsion containing both extracts, commercial and prepared, induced the largest and furthest repair of damaged tissue. This could be evidenced from day 3 to 28 by increase in collagen deposition from 40% to 240% and reduction on cellular inflammatory infiltrate from 3% to 46%. However, 8% prepared extract in emulsion presented the best efficacy. This work clearly demonstrates that comfrey leaves have a wound healing activity. The O/W emulsion showed to be the vehicle most effective to induce healing activity, particularly with extracts obtained from comfrey leaves collected in Minas Gerais state in Brazil. It shows the best efficacy to control the inflammatory process and to induce collagen deposition at 8% concentration. SN - 0031-7144 UR - https://www.unboundmedicine.com/medline/citation/22570943/In_vivo_wound_healing_effects_of_Symphytum_officinale_L__leaves_extract_in_different_topical_formulations_ L2 - https://www.lens.org/lens/search?q=citation_id:22570943 DB - PRIME DP - Unbound Medicine ER -