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Nephroprotective efficacy of chrysin against cisplatin-induced toxicity via attenuation of oxidative stress.
J Pharm Pharmacol. 2012 Jun; 64(6):872-81.JP

Abstract

OBJECTIVES

Cisplatin-induced nephrotoxicity is the main cause for its dose-limited use in the treatment of various cancers and results in acute renal cell injury through generation of reactive oxygen species. Chrysin possess antioxidant, anti-inflammatory and anti-cancer properties. The aim of this study was to investigate the protective efficacy of chrysin against cisplatin-induced nephrotoxicity.

METHODS

Thirty male Wistar rats were divided into five groups with six rats in each group. Group I served as control and received corn oil (vehicle of chrysin) for 14 days and 0.9% saline (vehicle of cisplatin) on day 14 only. Group II received a single intraperitoneal injection of cisplatin on day 14. Group III and IV were pretreated with two different doses of chrysin in addition to cisplatin and group V received chrysin only. Rats were examined for the effect of chrysin on cisplatin induced depletion of antioxidant enzymes, induction of lipid peroxidation and DNA damage in the kidney, utilizing a well-established model of cisplatin-induced nephropathy.

KEY FINDINGS

Pretreatment with chrysin significantly attenuated cisplatin-induced renal oxidative damage by diminishing the DNA damage and toxicity markers, such as creatinine and blood urea nitrogen, lipid peroxidation and xanthine oxidase activity, accompanied by increase in enzymatic (catalase, glutathione peroxidase, glutathione reductase and glutathione-S-transferase) and non-enzymatic (reduced glutathione) antioxidant status. Histological findings further substantiated the protective efficacy of chrysin, which reduced cisplatin-induced renal damage.

CONCLUSIONS

The data of the present study suggest that chrysin effectively suppress cisplatin-induced renal injury by ameliorating oxidative stress.

Authors+Show Affiliations

Molecular Carcinogenesis and Chemoprevention Division, Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard-Hamdard University, Hamdard Nagar, New Delhi, India. sarwat786@rediffmail.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22571266

Citation

Sultana, Sarwat, et al. "Nephroprotective Efficacy of Chrysin Against Cisplatin-induced Toxicity Via Attenuation of Oxidative Stress." The Journal of Pharmacy and Pharmacology, vol. 64, no. 6, 2012, pp. 872-81.
Sultana S, Verma K, Khan R. Nephroprotective efficacy of chrysin against cisplatin-induced toxicity via attenuation of oxidative stress. J Pharm Pharmacol. 2012;64(6):872-81.
Sultana, S., Verma, K., & Khan, R. (2012). Nephroprotective efficacy of chrysin against cisplatin-induced toxicity via attenuation of oxidative stress. The Journal of Pharmacy and Pharmacology, 64(6), 872-81. https://doi.org/10.1111/j.2042-7158.2012.01470.x
Sultana S, Verma K, Khan R. Nephroprotective Efficacy of Chrysin Against Cisplatin-induced Toxicity Via Attenuation of Oxidative Stress. J Pharm Pharmacol. 2012;64(6):872-81. PubMed PMID: 22571266.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nephroprotective efficacy of chrysin against cisplatin-induced toxicity via attenuation of oxidative stress. AU - Sultana,Sarwat, AU - Verma,Kriti, AU - Khan,Rehan, Y1 - 2012/03/22/ PY - 2012/5/11/entrez PY - 2012/5/11/pubmed PY - 2012/8/30/medline SP - 872 EP - 81 JF - The Journal of pharmacy and pharmacology JO - J Pharm Pharmacol VL - 64 IS - 6 N2 - OBJECTIVES: Cisplatin-induced nephrotoxicity is the main cause for its dose-limited use in the treatment of various cancers and results in acute renal cell injury through generation of reactive oxygen species. Chrysin possess antioxidant, anti-inflammatory and anti-cancer properties. The aim of this study was to investigate the protective efficacy of chrysin against cisplatin-induced nephrotoxicity. METHODS: Thirty male Wistar rats were divided into five groups with six rats in each group. Group I served as control and received corn oil (vehicle of chrysin) for 14 days and 0.9% saline (vehicle of cisplatin) on day 14 only. Group II received a single intraperitoneal injection of cisplatin on day 14. Group III and IV were pretreated with two different doses of chrysin in addition to cisplatin and group V received chrysin only. Rats were examined for the effect of chrysin on cisplatin induced depletion of antioxidant enzymes, induction of lipid peroxidation and DNA damage in the kidney, utilizing a well-established model of cisplatin-induced nephropathy. KEY FINDINGS: Pretreatment with chrysin significantly attenuated cisplatin-induced renal oxidative damage by diminishing the DNA damage and toxicity markers, such as creatinine and blood urea nitrogen, lipid peroxidation and xanthine oxidase activity, accompanied by increase in enzymatic (catalase, glutathione peroxidase, glutathione reductase and glutathione-S-transferase) and non-enzymatic (reduced glutathione) antioxidant status. Histological findings further substantiated the protective efficacy of chrysin, which reduced cisplatin-induced renal damage. CONCLUSIONS: The data of the present study suggest that chrysin effectively suppress cisplatin-induced renal injury by ameliorating oxidative stress. SN - 2042-7158 UR - https://www.unboundmedicine.com/medline/citation/22571266/Nephroprotective_efficacy_of_chrysin_against_cisplatin_induced_toxicity_via_attenuation_of_oxidative_stress_ L2 - https://doi.org/10.1111/j.2042-7158.2012.01470.x DB - PRIME DP - Unbound Medicine ER -