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The prospective association between total and type of fish intake and type 2 diabetes in 8 European countries: EPIC-InterAct Study.

Abstract

BACKGROUND

Epidemiologic evidence of an association between fish intake and type 2 diabetes (T2D) is inconsistent and unresolved.

OBJECTIVE

The objective was to examine the association between total and type of fish intake and T2D in 8 European countries.

DESIGN

This was a case-cohort study, nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) study, with 3.99 million person-years of follow-up, 12,403 incident diabetes cases, and a random subcohort of 16,835 individuals from 8 European countries. Habitual fish intake (lean fish, fatty fish, total fish, shellfish, and combined fish and shellfish) was assessed by country-specific dietary questionnaires. HRs were estimated in each country by using Prentice-weighted Cox regression models and pooled by using a random-effects meta-analysis.

RESULTS

No overall association was found between combined fish and shellfish intake and incident T2D per quartile (adjusted HR: 1.00; 95% CI: 0.94, 1.06; P-trend = 0.99). Total fish, lean fish, and shellfish intakes separately were also not associated with T2D, but fatty fish intake was weakly inversely associated with T2D: adjusted HR per quartile 0.97 (0.94, 1.00), with an HR of 0.84 (0.70, 1.01), 0.85 (0.76, 0.95), and 0.87 (0.78, 0.97) for a comparison of the second, third, and fourth quartiles with the lowest quartile of intake, respectively (P-trend = 0.06).

CONCLUSIONS

These findings suggest that lean fish, total fish, and shellfish intakes are not associated with incident diabetes but that fatty fish intake may be weakly inversely associated. Replication of these findings in other populations and investigation of the mechanisms underlying these associations are warranted. Meanwhile, current public health recommendations on fish intake should remain unchanged.

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  • Authors+Show Affiliations

    ,

    MRC Epidemiology Unit, Cambridge, UK.

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    Source

    MeSH

    Adult
    Animals
    Diabetes Mellitus, Type 2
    Diet
    Dietary Fats
    Energy Intake
    Europe
    Fatty Acids, Omega-3
    Female
    Fishes
    Follow-Up Studies
    Humans
    Incidence
    Male
    Middle Aged
    Proportional Hazards Models
    Prospective Studies
    Seafood

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    22572642

    Citation

    Patel, Pinal S., et al. "The Prospective Association Between Total and Type of Fish Intake and Type 2 Diabetes in 8 European Countries: EPIC-InterAct Study." The American Journal of Clinical Nutrition, vol. 95, no. 6, 2012, pp. 1445-53.
    Patel PS, Forouhi NG, Kuijsten A, et al. The prospective association between total and type of fish intake and type 2 diabetes in 8 European countries: EPIC-InterAct Study. Am J Clin Nutr. 2012;95(6):1445-53.
    Patel, P. S., Forouhi, N. G., Kuijsten, A., Schulze, M. B., van Woudenbergh, G. J., Ardanaz, E., ... Wareham, N. J. (2012). The prospective association between total and type of fish intake and type 2 diabetes in 8 European countries: EPIC-InterAct Study. The American Journal of Clinical Nutrition, 95(6), pp. 1445-53. doi:10.3945/ajcn.111.029314.
    Patel PS, et al. The Prospective Association Between Total and Type of Fish Intake and Type 2 Diabetes in 8 European Countries: EPIC-InterAct Study. Am J Clin Nutr. 2012;95(6):1445-53. PubMed PMID: 22572642.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The prospective association between total and type of fish intake and type 2 diabetes in 8 European countries: EPIC-InterAct Study. AU - Patel,Pinal S, AU - Forouhi,Nita G, AU - Kuijsten,Anneleen, AU - Schulze,Matthias B, AU - van Woudenbergh,Geertruida J, AU - Ardanaz,Eva, AU - Amiano,Pilar, AU - Arriola,Larraitz, AU - Balkau,Beverley, AU - Barricarte,Aurelio, AU - Beulens,Joline W J, AU - Boeing,Heiner, AU - Buijsse,Brian, AU - Crowe,Francesca L, AU - de Lauzon-Guillan,Blandine, AU - Fagherazzi,Guy, AU - Franks,Paul W, AU - Gonzalez,Carlos, AU - Grioni,Sara, AU - Halkjaer,Jytte, AU - Huerta,José María, AU - Key,Timothy J, AU - Kühn,Tilman, AU - Masala,Giovanna, AU - Nilsson,Peter, AU - Overvad,Kim, AU - Panico,Salvatore, AU - Quirós,Jose Ramón, AU - Rolandsson,Olov, AU - Sacerdote,Carlotta, AU - Sánchez,María-José, AU - Schmidt,Erik B, AU - Slimani,Nadia, AU - Spijkerman,Annemieke M W, AU - Teucher,Birgit, AU - Tjonneland,Anne, AU - Tormo,Maria-Jose, AU - Tumino,Rosario, AU - van der A,Daphne L, AU - van der Schouw,Yvonne T, AU - Sharp,Stephen J, AU - Langenberg,Claudia, AU - Feskens,Edith J M, AU - Riboli,Elio, AU - Wareham,Nicholas J, AU - ,, Y1 - 2012/05/09/ PY - 2012/5/11/entrez PY - 2012/5/11/pubmed PY - 2012/7/28/medline SP - 1445 EP - 53 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 95 IS - 6 N2 - BACKGROUND: Epidemiologic evidence of an association between fish intake and type 2 diabetes (T2D) is inconsistent and unresolved. OBJECTIVE: The objective was to examine the association between total and type of fish intake and T2D in 8 European countries. DESIGN: This was a case-cohort study, nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) study, with 3.99 million person-years of follow-up, 12,403 incident diabetes cases, and a random subcohort of 16,835 individuals from 8 European countries. Habitual fish intake (lean fish, fatty fish, total fish, shellfish, and combined fish and shellfish) was assessed by country-specific dietary questionnaires. HRs were estimated in each country by using Prentice-weighted Cox regression models and pooled by using a random-effects meta-analysis. RESULTS: No overall association was found between combined fish and shellfish intake and incident T2D per quartile (adjusted HR: 1.00; 95% CI: 0.94, 1.06; P-trend = 0.99). Total fish, lean fish, and shellfish intakes separately were also not associated with T2D, but fatty fish intake was weakly inversely associated with T2D: adjusted HR per quartile 0.97 (0.94, 1.00), with an HR of 0.84 (0.70, 1.01), 0.85 (0.76, 0.95), and 0.87 (0.78, 0.97) for a comparison of the second, third, and fourth quartiles with the lowest quartile of intake, respectively (P-trend = 0.06). CONCLUSIONS: These findings suggest that lean fish, total fish, and shellfish intakes are not associated with incident diabetes but that fatty fish intake may be weakly inversely associated. Replication of these findings in other populations and investigation of the mechanisms underlying these associations are warranted. Meanwhile, current public health recommendations on fish intake should remain unchanged. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/22572642/The_prospective_association_between_total_and_type_of_fish_intake_and_type_2_diabetes_in_8_European_countries:_EPIC_InterAct_Study_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.111.029314 DB - PRIME DP - Unbound Medicine ER -