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[Clinical study of Biqi Capsule combined with methotrexate for treatment of rheumatoid arthritis].

Abstract

OBJECTIVE

To observe the clinical effects of Biqi Capsule (BQC) combined with methotrexate (MTX) for treatment of rheumatoid arthritis (RA), and to study an effective protocol of RA treated by integrative medicine.

METHODS

One hundred and thirty-eight patients with RA were randomly assigned to Group I (44 cases, treated by BQC), Group II (46 cases, treated by MTX), and Group III (48 cases, treated by BQC combined with MTX). The therapeutic course for each group was 12 weeks. The degree of joint pain, the tender joint number, the tender joint index, the swollen joint number, the swollen joint index, the two-hand grip, the morning stiffness time, and related laboratory indices were observed in each group before and after treatment. The adverse reactions were recorded.

RESULTS

Compared with before treatment, there was statistical difference in the degree of joint pain, the tender joint number, the tender joint index, the swollen joint number, the swollen joint index, the two-hand grip, the morning stiffness time, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and rheumatoid factor (RF) in the 3 groups (P < 0.05, P < 0.01). Besides, better results were obtained in Group III (P < 0.01). As for the inter-group therapeutic efficacy, better results were obtained in Group III (P < 0.01). The gastrointestinal discomfort was the only adverse reaction in the 3 groups. No treatment was given due to its milder symptoms without any effects on the treatment.

CONCLUSIONS

BQC showed favorable effects on treating RA with no obvious adverse reaction. BQC combined with MTX showed better clinical efficacy than use of BQC or MTX alone. It could reduce the adverse reactions of MTX. BQC combined with MTX could reduce the toxic reactions and enhance the therapeutic effects, indicating it was an effective treatment program for RA.

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Authors+Show Affiliations

,

College of Traditional Chinese Medicine, Southern Medical University, Guangzhou (510515).

,

Source

MeSH

Adolescent
Adult
Antirheumatic Agents
Arthritis, Rheumatoid
Drug Therapy, Combination
Drugs, Chinese Herbal
Female
Humans
Male
Methotrexate
Middle Aged
Phytotherapy
Treatment Outcome
Young Adult

Pub Type(s)

English Abstract
Journal Article
Randomized Controlled Trial

Language

chi

PubMed ID

22574592

Citation

Jie, Hong-Yu, et al. "[Clinical Study of Biqi Capsule Combined With Methotrexate for Treatment of Rheumatoid Arthritis]." Zhongguo Zhong Xi Yi Jie He Za Zhi Zhongguo Zhongxiyi Jiehe Zazhi = Chinese Journal of Integrated Traditional and Western Medicine, vol. 32, no. 2, 2012, pp. 195-8.
Jie HY, Wu QF, Ding ZX. [Clinical study of Biqi Capsule combined with methotrexate for treatment of rheumatoid arthritis]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2012;32(2):195-8.
Jie, H. Y., Wu, Q. F., & Ding, Z. X. (2012). [Clinical study of Biqi Capsule combined with methotrexate for treatment of rheumatoid arthritis]. Zhongguo Zhong Xi Yi Jie He Za Zhi Zhongguo Zhongxiyi Jiehe Zazhi = Chinese Journal of Integrated Traditional and Western Medicine, 32(2), pp. 195-8.
Jie HY, Wu QF, Ding ZX. [Clinical Study of Biqi Capsule Combined With Methotrexate for Treatment of Rheumatoid Arthritis]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2012;32(2):195-8. PubMed PMID: 22574592.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Clinical study of Biqi Capsule combined with methotrexate for treatment of rheumatoid arthritis]. AU - Jie,Hong-Yu, AU - Wu,Qi-Fu, AU - Ding,Zhao-Xia, PY - 2012/5/12/entrez PY - 2012/5/12/pubmed PY - 2013/12/20/medline SP - 195 EP - 8 JF - Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine JO - Zhongguo Zhong Xi Yi Jie He Za Zhi VL - 32 IS - 2 N2 - OBJECTIVE: To observe the clinical effects of Biqi Capsule (BQC) combined with methotrexate (MTX) for treatment of rheumatoid arthritis (RA), and to study an effective protocol of RA treated by integrative medicine. METHODS: One hundred and thirty-eight patients with RA were randomly assigned to Group I (44 cases, treated by BQC), Group II (46 cases, treated by MTX), and Group III (48 cases, treated by BQC combined with MTX). The therapeutic course for each group was 12 weeks. The degree of joint pain, the tender joint number, the tender joint index, the swollen joint number, the swollen joint index, the two-hand grip, the morning stiffness time, and related laboratory indices were observed in each group before and after treatment. The adverse reactions were recorded. RESULTS: Compared with before treatment, there was statistical difference in the degree of joint pain, the tender joint number, the tender joint index, the swollen joint number, the swollen joint index, the two-hand grip, the morning stiffness time, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and rheumatoid factor (RF) in the 3 groups (P < 0.05, P < 0.01). Besides, better results were obtained in Group III (P < 0.01). As for the inter-group therapeutic efficacy, better results were obtained in Group III (P < 0.01). The gastrointestinal discomfort was the only adverse reaction in the 3 groups. No treatment was given due to its milder symptoms without any effects on the treatment. CONCLUSIONS: BQC showed favorable effects on treating RA with no obvious adverse reaction. BQC combined with MTX showed better clinical efficacy than use of BQC or MTX alone. It could reduce the adverse reactions of MTX. BQC combined with MTX could reduce the toxic reactions and enhance the therapeutic effects, indicating it was an effective treatment program for RA. SN - 1003-5370 UR - https://www.unboundmedicine.com/medline/citation/22574592/[Clinical_study_of_Biqi_Capsule_combined_with_methotrexate_for_treatment_of_rheumatoid_arthritis]_ L2 - http://www.diseaseinfosearch.org/result/592 DB - PRIME DP - Unbound Medicine ER -